#1

Hello, I’m relatively new to the site. I’ve been on rapamycin for almost 3 weeks, I took 1mg my first sunday, 3mg the next and 5 last sunday. I added a continuous glucose monitor about 10 days ago and there was definitely a jump in glucose after the rapamycin so I added metformin about a week ago.

I had no issues with the metformin until last night around 9pm I randomly decided to drink some strong ginger tea. About 20 minutes later my CGM alarm goes off- glucose 69. Then it kept going down and down. When it got to 50 I was pretty much freaking out so I drank apple juice and ate several teaspoons of white sugar, after 5 minutes it was up to 160.

I’m curious if anyone else has had significant hypoglycemia events with metformin; I’ve stopped it for now and might try acarbose instead.

As a side note, after this episode happened my CGM kept putting error messages (it’s libre 3 brand) so I applied a new one which started putting out numbers that were consistently 20 above the fingerstick value. I called the company and they’re sending a free replacement. But then the NEXT one I put on is 40 points above the fingerstick! I just checked and the CGM says 121 while fingerstick is 80. I know @RapAdmin has stated that sometimes you get a bum CGM with inaccurate readings but 2 in a row? Just bad luck?

#2

What do you mean by jump in glucose from Rapa? How high for how long?

#3

My fasting glucose at my annual physicial for years is always in the 80s. For the first 24 hours after taking the rapa it was between 100-110 when fasting, with spikes to 130-140 after lunch and dinner (I do 18/6 fasting and very low carb). Then it gradually went down each day until Saturday when fasting was back to 85 or so.

#4

No, its not so much that you’re getting a bad CGM sensor, I think its that the Freestyle libra 2 is just not a very accurate measure of blood glucose measures. I’ve got a friend with diabetes and he says its just not a very good system - and he suggested I do a blood stick measure every morning at the same time I look at the CGM to see how far off it is. The blood stick measure is very accurate. I think the Libre 3 may be more accurate.

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#5

They are libre 3, supposedly the most accurate one! When I called customer service they recommended leaving it on for 24 hours to let it “get adjusted” before discarding it. I’m now wondering if my “elevated glucose” after rapamycin was an artifact since it was a newly applied CGM, on the day of my 5mg dose. Hard to believe people manage their diabetes with these things if they’re so inaccurate.

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#6

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I mean… seriously?

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#8

I see that very often. That’s why I prefer the Dexcom CGMs because they can be calibrated with fingerprick measurements.
I’m eating low carb too so I don’t care if the blood glucose goes very low as I’m in ketosis anyway.

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