I disagree. Perception is what matters, not reality. Asprin is deadly, but the perception is its benign: A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use - PubMed
Death rate attributed to NSAID/aspirin use was between 21.0 and 24.8 cases/million people, respectively, or 15.3 deaths/100,000 NSAID/aspirin users. Up to one-third of all NSAID/aspirin deaths can be attributed to low-dose aspirin use.
According to wikipedia, aspirin has been used (either in its precursor form - Willow bark - or current tablet form) for 2400 years by humans and is generally assumed to be safe, but here is a 2010 conclusion on aspirin: Critical Overview on the Benefits and Harms of Aspirin - PMC
Conclusions
This overview of recently published meta-analyses suggests that aspirin therapy has significant benefits in a variety of clinical settings, but there are still uncertainties that will require more research. Current evidence suggests that aspirin is beneficial for secondary prevention for cardiovascular disease, primary prevention of pre-eclampsia, and secondary prevention of colorectal adenomas. However, use of aspirin in primary prevention of cardiovascular disease, or in patients with diabetes mellitus, or in those with peripheral vascular disease is not supported by the current evidence. It is also clear that aspirin has considerable potential for harm in patients undergoing surgical procedures. The benefits of aspirin use must be weighed clinically against the risk of adverse events such as gastrointestinal and intracranial bleeding.
As Matt Kaeberlein has said, rapamycin is not popular yet, because of
âBad (undeserved) reputation, Lack of profit motive (generic drug), Bureaucratic barriersâ
and your infographic, if you highlight or focus on the perceived risk and worse case scenarios, will further stigmatize the medication. You could make the case that Aspirin is deadly and shouldnât be sold, but that wouldnât be helpful for most people (but of course, aspirin has had a huge company Bayer, marketing aspirin for decades). Similar situation with rapamycin⌠but without the marketing.
See this thread/discussion below:
And this post:
People have tried to overdose on rapamycin, taking 103mg at once, and suffered no serious negative effects⌠so please, donât make rapamycin out to be more risky than it actually is:
As weâve seen reported by the users here, side effects are mostly minor and temporary and go away without treatment or with cessation. I think youâd likely get a side effect profile that is similar if you compared âexerciseâ and âperiodic alcohol consumptionâ with the rapamycin side effects - yet rapamycin has a demonstrated effect of lengthening lifespans in all organisms tested by 15% to 25% typically.
Humans (generally) have great difficulty in risk/reward tradeoffs and calculations, and the simplistic âdo no harmâ approach of the modern medicine establishment results in significant harm to vast segments of the population (I believe), in terms of avoiding preventative approaches like rapamycin.
And, its important to put things in perspective⌠people recommend / or participate in things like exercise and alcohol consumption, both of which likely have much higher side effect profiles than rapamycin:
Also - some other observations:
