Reverse Gray Hair, Hair Repigmentation

[cl-user]

Looks like One Skin now makes an hair serum with their OS-01 senolytic peptide.

One of the papers they give as a rationale for that:
Restoration of hair follicle inductive properties by depletion of senescent cells

[Phillipe]

That’s interesting. I may get some and apply after microneedling.

[RapAdmin]

Our result is interesting as hair darkening has not been formally reported as a side effect of cholinesterase inhibitors, and our findings will add to the list of drugs which can cause re-pigmentation of grey hair. Although cholinesterase inhibitors have been widely used for over two decades, darkening of grey hair has not been reported previously, which could be perceived as unusual. Possible explanations include a prolonged period of use is required for hair darkening to reach a level at which it becomes clinically detectable. Furthermore, patients often do not remain with their memory clinic physician long enough for the change to be observed, or the patients’ hair colour is not usually monitored as hair colour change is not an alarming complaint.

We focused on patients with a minimum 6 months drug use as scalp hairs grow at a rate of approximately 1cm per month.10 Thus, we assumed that at least 6 months would be likely to be required before the changes were clinically noticeable.

The mechanism of cholinesterase inhibitor-induced hair darkening is not known. Possible mechanisms include increased production of melanin due to activation of melanocytic stem cells or stimulation of melanogenesis.2 We found no significant difference in melanin concentration in darkened hair of patients treated with cholinesterase inhibitors and the dark hair of control subjects. This is consistent with the hypothesis of increased melanin production, and the findings suggest that the darkening of hair is less likely due to the deposition of a drug metabolite.

Interestingly, the most common site of hair darkening was the occipital region (70.9% patients with hair darkening). The reason for this is unclear. It has been noted in men that grey hair typically begins at the temples, and then spreads to the cranial vertex and lastly the occipital area.11 Perhaps the reverse may be true if re-pigmentation occurs.

Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population - PubMed

[Ludovic]

This topic is also very interesting;

Luteolin, an antioxidant in vegetables, may contribute to the prevention of hair graying

Luteolin, an antioxidant in vegetables like celery and broccoli, shows potential in preventing hair graying by preserving melanocyte activity, offering a promising avenue for anti-aging hair care solutions. The similarities between the hair graying processes in the model mice and humans offer encouraging prospects for translating these findings into human applications. In addition to being found in vegetables, luteolin is already available as a supplement for topical and oral use, making it a viable candidate for further development as an anti-graying treatment. As research progresses, this antioxidant could become a key ingredient in hair care regimens, helping individuals preserve their natural hair color as they age. Open Access Paper: Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and dio…

[John_Hemming]

Luteolin is a HDAC inhibitor