#691

Looks like One Skin now makes an hair serum with their OS-01 senolytic peptide.

One of the papers they give as a rationale for that:
Restoration of hair follicle inductive properties by depletion of senescent cells

3 Likes
#692

That’s interesting. I may get some and apply after microneedling.

#693

Our result is interesting as hair darkening has not been formally reported as a side effect of cholinesterase inhibitors, and our findings will add to the list of drugs which can cause re-pigmentation of grey hair. Although cholinesterase inhibitors have been widely used for over two decades, darkening of grey hair has not been reported previously, which could be perceived as unusual. Possible explanations include a prolonged period of use is required for hair darkening to reach a level at which it becomes clinically detectable. Furthermore, patients often do not remain with their memory clinic physician long enough for the change to be observed, or the patients’ hair colour is not usually monitored as hair colour change is not an alarming complaint.

We focused on patients with a minimum 6 months drug use as scalp hairs grow at a rate of approximately 1cm per month.10 Thus, we assumed that at least 6 months would be likely to be required before the changes were clinically noticeable.

The mechanism of cholinesterase inhibitor-induced hair darkening is not known. Possible mechanisms include increased production of melanin due to activation of melanocytic stem cells or stimulation of melanogenesis.2 We found no significant difference in melanin concentration in darkened hair of patients treated with cholinesterase inhibitors and the dark hair of control subjects. This is consistent with the hypothesis of increased melanin production, and the findings suggest that the darkening of hair is less likely due to the deposition of a drug metabolite.

Interestingly, the most common site of hair darkening was the occipital region (70.9% patients with hair darkening). The reason for this is unclear. It has been noted in men that grey hair typically begins at the temples, and then spreads to the cranial vertex and lastly the occipital area.11 Perhaps the reverse may be true if re-pigmentation occurs.

Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population - PubMed

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#694

This topic is also very interesting;

3 Likes
#695

Luteolin is a HDAC inhibitor

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#696

hello @RapAdmin and others,

Just wondering if anyone here has tried this formula and actually seen any results - good or bad. Would love to hear your experience. Also, has there been any new info or breakthroughs around reversing grey hair?

1 Like
#697

How often do you use rapamycin?

#698

Then reducing agent can help?

#699

As a preventative most likely yes. To reverse we would need something more robust.

#701

I am not sure if it’s that simple.

There isn’t anything proven to work. However I am trying a general kitchen sink approach mainly geared towards hair growth/preservation, hoping some of the intervention can reduce graying.

A. For hair directly:

  1. Musely modern hair solution with
  • iPSC Exosomes 250 million/bottle
  • Latanoprost 0.004%
  • Caffeine 0.5%
  • Cetirizine 1%
  • Melatonin 0.1%
  1. Costco Minoxidil
  2. Oral dutasteride
  3. Carol’s Daughter Goddess strength Fortifying Shampoo & Conditioner with Black Cumin, Castor Oil and Ginger. - I tried this from Costco and it moisturizes the hair, not sure if any of the ingredients actually do anything but can’t be worse than using Pantene.
  4. No hair dryers or hair products for most part.

B. Anti-inflammatory diet - Green med style.
C. Exercise.
D. Sleep
E. Stress management

For 51, I have about 50-70 gray hair strands - not too bad, maybe something is working. Strangely my facial hair is more prone to graying, so more incentive for staying clean shaven.

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#702

I would not say that is unusual.

2 Likes