If someone doesn’t need BMS-202 anymore,please, share with me, I am willing to buy it …
WhatsApp: +86 166-210-06118
BMS-202 300mg $75.
You would probably need more than 1g.
AnUser
#627
I would be careful about getting scammed and people on reddit seems to think it is risky for health to use compounds like this at this stage:
https://www.reddit.com/r/tressless/comments/16z4h68/huge_group_buy_is_now_live_with_new_and_existing/
1 Like
Eggman
#628
How did you buy L-tyrosine and 500mg of inositol? Just in capsule form (as in oral suppkement)? And you added into liquid glycerin?
Ive scanned this 600+ post thread, its not clear if anyone has had success trying to reproduce rt’s formula. Anyone have results?
4 Likes
Finally a update from Eirion therapeutics a company who went quiet since 2021 when they got massive funding but it seems they are starting phase 1 trials for their et-02 topical for androgenetic alopecia and they seem pretty confident that it is better than anything currently on the market and basically close to a cure they believe it will completely prevent hair loss as it is a PAI-1 inhibitor and they believe it will reactivate dormant hair follicle stem cells damaged or aged and return them to a healthy normal state and re grow hair again. Also of much interested as they go on to say that they are confident this will treat and prevent gray hair as it also works on melanocyte stem cells to a healthy normal state again thus regrowing pigmented hair. They plan to further go down this route in the future as stated but I’m wondering if it is already going into trials for androgenetic alopecia can they not see that it also reverses gray hair rather than doing separate trials and taking much longer? Let me know what yous think of this.
2 Likes
Karel1
#636
For me this looks like nothing more or less than an other advertorial.
Cannot find a study protocol with methods, inclusion criteria etc.
Doing separate trials can have valid reasons but can also be a method to avoid negative results on one outcome to take down the substance for all indications.
The text states testing for safety. So even after this the question of result remains open.
We’ve been discussing “cholinesterase inhibitors” in many aspects of longevity on our forums for the past year or two. This is the first I’ve seen with regard to hair repigmentation:
Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population
Eighty consecutive Chinese patients diagnosed with Alzheimer disease were assessed for darkening of grey hair. Of the 62 eligible patients (mean age = 79.3 ± 7.9 years; male: female = 1:1.48), 24/62 (38.7%, 95%CI: 26.6 – 51.9) reported hair darkening after prolonged usage of cholinesterase inhibitor for at least 6 months. Of the 24 patients with hair darkening, 17 (70.9%) experienced hair darkening in the occipital region, 3 (12.5%) in the parietal region, 2 (8.3%) patients in the frontal region and 2 (8.3%) patients experienced hair darkening in multiple regions. Analysis of melanin concentration showed no significant difference between darkened hair of patients after prolonged drug use and the dark hair of controls (P = 0.381).
Paywalled article summary:
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.13356
Full Paper PDF here: Sci-Hub | Re‐pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population. Australasian Journal of Dermatology | 10.1111/ajd.13356
6 Likes
david7
#638
I agree. Clearly a fairly yukky smell after applied. The ingredients include sulfur.
Any idea which one and what does they are using?
Lost
#640
Did you quote a different post than you’re replying to?
david7
#641
Sorry. First post on this forum.
I was posting about GR-7. Don’t know how I got turned around.
GR-7 did work for me. But some gray areas–the ones which had been gray for the longest time–are slower to get back color like the other areas on my head have.
The smell, as I said, is a bit of a bummer. You don’t smell it when just smelling the product. It seems to be only after it is on one’s head a while. Sulfur is listed as an ingredient, and I guess it is an approximately sulfuric odor–though not exactly.
1 Like
Came across this, sounds rather interesting but not any Info I can find as just patent
Also https://areygrey.com/
I heard a dermatologist say on a YouTube video that none of GR-7, Arey, or Mayraki had done controlled trials unfortunately, at least not yet.
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Just to confirm risks of long-term ingestion of finasteride: a few men posted on the longecity.org website that they personally experienced anhedonia, ED, and/or other adverse effects after long-term ingestion of finasteride or saw palmetto. Do a web search for “post-finasteride syndrome” to learn more. Or go to About Post-Finasteride Syndrome – The Post-Finasteride Syndrome Foundation
1 Like
If you search on reddit, people have claimed to have gotten PFS/PSSD from even supplements such as Ashwagandha. I tend to not trust people’s claims because many of them, especially on the internet, are either hypochondrics, liars or would’ve developed ED naturally (tadalafil/sidenafil wasn’t invented to treat finasteride and antidepressant side effects).
Besides that, your source is a litigious organisation. In one of the trials against Merck by the PFS Foundation, the FDA stated as following.
In 2017, the Post Finasteride Syndrome (PFS) advocacy group petitioned for a stop to selling of the drug or advertisement of stronger warnings. The US Food and Drug Administration (FDA) had advised that the PFS petition “does not provide reasonable evidence” of a link to suicide, but in August 2022 added suicidal ideation (SI) and behaviour to the adverse reactions listed for finasteride. According to the FDA statement, the PFS petition “does not provide reasonable evidence” of a causal link between finasteride and persistent SD, depression, or suicide. However, on the basis of reports from patients using the 1-mg dose for AGA, the FDA is “requiring the addition of SI and behaviour” to the listed AEs.
US Food and Drug Administration Warning Regarding Finasteride and Suicidal Ideation: What Should Urologists Know? - ScienceDirect
3 Likes
AnUser
#646
I saw a thread on reddit where one person said that finasteride made him hear voices. I wonder what else he hallucinated.
ED from finasteride is real however, although rare, and most cases as far as I understand resolve after drug cessation. This doesn’t mean these people aren’t genuinely suffering, it’s most likely not from finasteride though, and that ‘community’ isn’t helping them at all.
3 Likes
Cohen
#647
Dutasteride is safer than finasteride. Make sure to take tadalafil before bedtime to ensure the penile tissue stays well-oxygenated throughout the night.
Our study showed no increased risk of suicidal behaviour in the general population of men treated for BPH with finasteride relative to those treated with dutasteride, particularly, among men without psychiatric disorders. However, among men with a history of mood disorders, we found that finasteride may be associated with a higher risk of suicide death and severe self-harm with the use of violent means or admission to an intensive care unit than dutasteride.
Biological evidence on the impact of finasteride on suicidal behaviour is very scarce57. Biological studies have instead investigated the mechanisms involving finasteride or 5α-reductase inhibitors in the development of depression, including alterations in neuro-steroid levels (notably allopregnanolone), dopaminergic dysfunction, reduced hippocampal neurogenesis, increased neuro-inflammation, alteration of the hypothalamic–pituitary–adrenal axis, and epigenetic modifications58. The increased risk of suicide death or severe self-harm among men with previous mood disorders treated with finasteride relative to those treated with dutasteride could be explained both by an increased suicidal risk with finasteride, as well as a protective effect of dutasteride59. It is not possible to distinguish between these two hypotheses with the data used for our study. Finasteride is known to cross the blood–brain barrier and thus can affect concentrations of neuro-steroids and their metabolites in the cerebrospinal fluid16,17,18,60,61,62. It is not currently clear to what extent dutasteride also crosses the blood–brain barrier and further biological investigations are needed to address this issue, as such a difference could explain the difference observed in our study between two drugs of the same pharmacological class. It cannot be excluded that dutasteride is also associated with an increased suicidal risk for at-risk individuals.
https://www.nature.com/articles/s41598-023-32356-3
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