#81

I start from a position where I don’t think the epigenetic tests are that predictive whoever does them. However, I am happy to see what comes from this.

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#82

Looks like Novos Labs also offers DunedinPace.

Does anyone know the difference between Novos and TrueDiagnostics?

E.g. does each process the in their own facility or do they both send to the same lab for processing?

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#83

DunedinPACE may be the best current epigenetic based clock for the type of interventions in this community and the type of epigenetic tests that might best pick up effects even after short durations of interventions.

“The methods proposed to quantify biological aging analyzed in this study are predictive of aging-related health decline and mortality. However, until this study, none had been tested in a randomized controlled trial of a geroscience-based intervention49. Our findings highlight DunedinPACE as a measure with potential utility in future trials. DunedinPACE has high test–retest reliability and shows strong associations with healthspan endpoints in validation analyses24,29. Ultimately, establishing DunedinPACE and other DNAm measures of aging as surrogate endpoints for geroscience will require evidence that changes in DNAm measures account for intervention effects on primary healthy-aging endpoints, including incidence of chronic disease and mortality18,19,20. The evidence reported from CALERIE suggests that DunedinPACE may be helpful in identifying short-term interventions worthy of long-term follow-up to generate such evidence.”

www.nature.com/articles/s43587-022-00357-y

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#84

With me, the DunedinPace numbers were the only ones that made any sense and that isn’t proprietary to Tru-Diag. As I said, I won’t be wasting any more money with them.

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#85

Well the second sample was sent by me through UPS in the UK on 6th April and was delivered to trudiagnostics at 9am this morning.

1 Like
#86

Well, some time later, I have some results. It is all a bit confusing really.

DunedinPACE: 0.78
Intrinsic Age New Algo: 62.93
Intrinsic Age Old Algo: 43.05
Extrinsic Age: 47.25
Telomeres: 6.85kb (low for my age).

(I am chronologically 63 and was when the tests were done).

I am not a great fan of epigenetic age tests. I prefer the functional tests. I wonder what TruDiagnostics are doing with the changes to their algorithms. It strikes me that if they are relying on their customers to be an average set of human beings that is an error and this could skew their biological age calculations. That may be the meaning of the old algorithm.

I have, however, decided to run these tests again. I do have a baseline. I already have lots of other tests and it would be good to see if anything shifts. It is important to remember that when I started trying to improve my health I was 130kg and has a number of health problems that have now gone. I don’t have a baseline telomeres figure so it will be interesting to see if this shifts.

The response as to immune cells is quite interesting with an analysis into B CD4 CD8 and NK lymphocytes. They seem to report that I don’t have any CD8 cells.

1 Like
#87

I am not quite ready for the Rejuvenation Olympics because I don’t have any DNA methylation tests to submit.
But I am very happy with my latest results from Quest Diagnostics.
My most recent blood work was great and my age delta is from Aging.ai

Input:

1209×570 18.9 KB

Result:

From the Levine-derived spreadsheet:

1297×453 39.7 KB

Interestingly if I use the predicted age from the Aging.ai calculator I still get a very good delta on the Levine-derived spreadsheet:

1301×444 39.4 KB

The bottom line here is that the Levine-derived spreadsheet gives actual age a large weight in the calculation.

I only use these as markers for my healthspan/lifespan journey.

They are more convenient and cheaper than the DNA lab tests and I can find no convincing evidence that the DNA methylation tests are any better predictors of life expectancy. Since life extension via rapamycin, metformin, etc., is a relatively new area of study, we may have to wait decades to see who got it right.

At 82 my predicted age based on my birth year, demographics, and genetic heritage is approx 93. Based on the Social Security Actuarial Life Table my predicted end is at ~89 years.

So, if I continue to stay healthy enough to post to this forum I will be a little like the canary in the coal mine and we will see if my interventions do anything other than extend healthspan.

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#88

Extending healthspan is key. It is likely also to extend lifespan.

I prefer the biomarker formulae (to methylation) because they are linked to mortality predictions.

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#89

I’m quite late to this thread party but just an FYI any interested in TruDiagnostics test, the code RAAD30 will make it $349.30 instead of $499.

Has anyone tested with them recently and gotten the OMICmAge Report or physical fitness report?

#90

TruDiagnostic Epigenetic Age Calculator Revealed!

According to this, I am only 18 years old!

After a re-test, I am only 4! It’s amazing that another test can take 14 years off your age.

I’m sold. It’s gotta be accurate. :wink:

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#91

@DesertShores I predict your last post here will be in December of 2065.

But that’s just my conservative guess. It could be later… :wink:

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#92

I had these reports run on my previous test results which were from samples in July and April. (2023). I think what they do is to look at methylation patterns in lymphocytes.

As I do weekly blood tests I know what my actual biomarkers were around the time the test samples were taken (in fact from a sample on the same day). For example Omicm age had HbA1c as 6.51, but the actual result (I have not looked up the specifc day) is in the range of 4.18-4.9.

Hence although I am interested in the abstract in seeing what changes there are I have some doubts about the values.

I have a third box to do a sample with which I intend to use when I am running the most intense version of my protocol. (I have not tested all the components yet, but now I have resolved what I saw as a calcium depletion caused increase in blood pressure, I intend slotting in a strategy for this.

1 Like
#93

People are commenting that this video is just elaborate product placement / PR for Novos

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#94

If anyone wants a discount code for the full Tru test, send me a message and I’ll provide the one we have.

My wife and I will be “joining” as soon as we get a link that allows us to use our previous 4 tests as an entry to the Olympics!!

The boss could be in the top 10 with her 0.74 Pace score. Me, not so much with my current best score of 0.94

It looks like they will also be including the new SymphonyAGE
Hers is 52 at her chrono-age of 67
Mine is 73 at my chrono-age of 68

We are examples of same protocols with different results

I think we would be a good “case” as we live in the same home, eat the same things, are on the same “protocols”, take the same supplements, etc. Only differences are;

  1. 1 year in age
  2. male vs female
  3. she is more physically active than me but I’m working on that :blush:

And of course genetics.

SymphonyAGE

Created by Yale University, with development spearheaded by epigenetic pioneer Dr. Morgan Levine, SYMPHONYAge can only be accessed by purchasing a TruAge COMPLETE test, visiting a TruDiagnostic partnered healthcare provider, or by upgrading a previous TruAge COMPLETE test.

1 Like
#95

There is definitely an incentive to provide worst results possible. Test interpretation can be easily manipulated (naturopaths do it all the time). This way the company can sell you a solution and also sell you repeat tests.
I am not saying that they are actually fudging the tests but there is definitely a big financial incentive to do so.

Is there any legit place one can get a DunedinPACE done with accurate interpretation ?

3 Likes
#96

Trudiagnostic doesn’t sell solutions only tests.

And yes, like any test, the results will change based on my lifestyle. I still get my annual (and a semi-annual) blood panel through my GP so I can see deficiencies and make appropriate changes to my lifestyle to improve and then test again and again and again. Is taking multiple tests over time a problem? or part of the solution?

Also there are 2 Dunedin algo’s Dunedin PoAm (the first one) and Dunedin PACE the latest version. As far as I know, they use the most current PACE version in the RO.

I’m not sure how else to interpret the Dunedin Pace results. It’s basically a speedometer that shows the “pace” of aging at the time the blood was drawn. You are either above >1, at =1 or below <1. Which is interpreted as, 1 means you age 1 day for every day you live. I’m below 1, 0.94, my wife is below 1, 0.74, theoretically we are aging “slower”.

The simplicity of the result is one of the things that makes it less “interpretable”.

I guess you would need your raw epigenetic data and run it through the same algorithm that Tru licenses from Duke University.

Some info on the newest Dunedin Pace algo.

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#97

If one wanted to get into the meat and potatoes of the DunedinPACE test check this out. All the info a data geek could ever want :slight_smile:

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#98

I think the developers of these types of bioclock tests typically only do exclusive licensing (businesses really want this, to minimize competition) - so I don’t think anyone but TruDiagnostics can provide the test (or, likely, the evaluation) of the DunedinPace protocol/data/analysis.

#99

Novos offers it as well, I think

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#100

I stand corrected!

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