I need to read the paper you’ve provided. It could also be a situation where (as the previous post I made) the healthier, more fit, lower BMI people have higher testosterone levels, and also lower epigenetic age.
I wonder if there are studies where exogenous testosterone is looked at and compared pre/post with epigenetic age. That would be interesting to know.
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Hadley
#82
I just sent my doctor a message requesting to be put on 5mg daily of Tadalifil for its cardiovascular protective effects.
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Both in essence are anti-aging drugs and one can enhance the effects of the other!
I currently use test 250mg once per week as a anti-aging/lifestyle drug well as many other supplements in addition to 5mg per week of Rapamycin and have not experienced any adverse effects!
Rapamycin wont lose its potency if taken with other drugs so the combination of test and rapamycin is perfectly fine!
Hope this helps with your predicament!
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Great choice according to my urologist tadalafil is excellent for male health and the side effects… very desirable. 
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I wouldn’t class testosterone as an anti-aging drug as it does nothing to halt the aging process (if anything it could marginally speed it up). I would put it in the same category as other performance enhancers such as creatine etc, certainly it can enhance healthspan in some people but not lifespan. Agree that there is no appreciable interaction between TRT and rapamycin.
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Hadley
#86
what do you think a happy medium Testosterone level would be in the blood when it comes to the normal range in order to not accelerate aging with over activation of mTOR? Mid range or upper range? without intervention im around 271 ng/ml, which is low for my age. I know I feel way better mentally on Testosterone Cypionate 2x weekly. Right now I’m taking 100mg every 3.5 days instead on one large 200mg dose once weekly that has a spike and fall. thinking of dropping it down to somewhere between 50-75mg every 3.5 days. then get lab tests done. I’m pretty sure my current dosage puts me close to high normal.
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Other people would have different opinions I’m sure (and I am not a TRT user) but assuming you are symptomatic at a T level of 271ng/dl I’d go for mid range (which for me would be around 500ng/dl). Because T levels are more stable (on a daily timeframe) with TRT and free T can be slightly higher, mid range TRT is like high range natural already.
We know if you push T too high it can have a detrimental effect on cardiovascular health and longevity so if it were me I would go only as high as needed to feel better. Regarding more frequent dosing that will only be a benefit aside from the inconvenience.
Some people have a level of 200ng/dl, feel fine and don’t need TRT others have symptoms at 300ng/dl. I wouldn’t focus hugely on what is low for “your age” but rather what do you need to feel good. There is a lot of variance between individuals.
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Hadley
#88
i definitely had low T symptoms, like low mood, low sex drive, decreased strength. My memory also improved a little with TRT. The mood boost to me is the best part. I think I’ll try somewhere around 60mg every 3.5 days. wait and get labs.
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Hadley
#89
I know Bryan Johnson who takes Rapamycin along with several other longevity type drugs, has a naturally high Testosterone level now after he switched from a 20% caloric restriction to 10% along with his workout regimen.
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I wasn’t at all trying to imply you didn’t have symptoms, was just trying to say focus more on the symptoms than the absolute number. If you feel good at 400ng/dl great, if it takes 800ng/dl also fine.
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Free T is the most relevant number, and it’s best tested with an LC/MS with Dialysis test (about $90 through Marek Diagnostics, I think cheaper through DiscountLabs (quest).
Total T isn’t as meaningful because it binds to albumin and SHBG. SHBG varies a lot person to person.
The cheap assay tests will give you a rough idea of where your total T is, but they are also inaccurate compared to LC/MS.
On dosing: The doses that I see across the forum are really borderline steroid cycle doses (supraphysiological) rather than testosterone replacement doses unless somebody’s SHBG is absolutely through the roof. With testosterone dosing, less is often more. Men very frequently feel better on 70-150(max), and if body fat is low enough, one often won’t need to take an aromatase inhibitor.
And of course injecting at least twice a week is a bit closer to natural, but that also depends on how much you aromatize into estradiol. (Use the sensitive test for estradiol)
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Hadley
#92
I just reduced down to about 65mg this morning(2x weekly) and ill continue at this dose until I get my lab results to know whether to go down or up. Thanks!
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scta123
#93
Did he stop TRT? I wasn’t aware of this.
scta123
#94
I believe it is the free T that counts more than total T. I have my total T at lower end but my free T is in mid normal range which probably makes the difference.
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I did a quick read on Tadalifil being protective for CVD and it seems there is solid evidence that it helps protect against CVD. But since it is given to men with ED (which i am guessing could have something to do with CVD and could be an indicator something is wrong) maybe it wouldn’t do anything for people with ok/good circulatory systems?
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Rough to know - these agents increase nitric oxide, which is a vasodilator. Nitric oxide synthase - our endogenous source of nitric oxide decreases with age. The combination of avoiding mouth wash, acid blockers (especially PPI’s) and adding cruciferous vegetables and beets will increase your exogenous nitric oxide. Tadalifil will do this chemically to a degree, and for older individuals, theoretically it could be helpful.
I prefer the natural route myself. Also for many individuals, at least for the pharma version, it doesn’t work that great, in regard to treating ED - which could relate to how much nitric oxide it successfully generates.
All of this is theoretic, as I’m not aware of literature showing outcome in other individuals, as the usual indications for this medication often coincides with significant vascular disease (often undiagnosed).
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AnUser
#97
Seemingly good, at least entertaining video about testosterone, and a bit viral.
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I thought this guy did a really good job on that video. Would hope anyone thinking of heading down that route with androgenic steroids understand what they are getting into
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Of course, important to note that anabolic steroid potency and dose to get effects seen in bodybuilders are MUCH higher than what’s done with testosterone replacement. Great video from Dr. Mike on the topic here:
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I dose rapa at the test low point or trough based on days between . Seems to make sense as one is doing the opposite of the other as related to mtorc. I did find a heart cell study related to both to be helpful.[quote=“David, post:1, topic:1719, full:true”]
Hello All! Anyone use both rapamycin and testosterone replacement? Thoughts on timing?
[/quote]
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