David
#1
Hello All! Anyone use both rapamycin and testosterone replacement? Thoughts on timing?
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MAC
#2
Yes, I do, bi-weekly self-injections (3.5 yrs). I take Rapamycin weekly (1.5 yrs), currently exploring with increased dosing levels. I have not any reason or knowledge to concern with overlap/timing.
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Isnāt exogenous testosterone mTORC1 activating? It seems that they would be contra-indicated.
The S6K1 phosphorylation induced by testosterone was blocked by rapamycin and small interfering RNA to mTOR.
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MAC
#4
Yes, it does, I am certainly balancing several longevity pathways. I might need some extra Rapamycin 
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It also seems you would want to time them such that they are opposite in terms of dosing schedule, wouldnāt you? i.e. dose the testosterone when Rapamycin is at its trough blood levels?
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David
#6
Thank You! I have seen some posts that try to balance metformin and exercise and did not know if some people were trying to do similar strategies with TRT and Rapamycin with activating and deactivating mTOR. It would make sense that as younger men we have higher testosterone levels yet seem to have better mTOR regulation although I have not seen many discussions of comparing mTOR regulation in young vs. old.
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David
#7
Yes, exactly what I was thinking and may make sense of doing biweekly Rapamycin when doing TRT? Any information that you have seen on how mTOR regulates differently in younger vs. older?
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Yes, I have been on TRT 3 years nowā¦ helped with weight loss in combination with rapamycin for visceral fat loss. Maintaining muscle.
Started rapamycin 1 year after the TRT. I think the combination of the two is a good match.
I do rapamycin on Monday. Cypionate on Thurs.
I figure any negative effects of Cypionate are corrected by rapamycin biology regeneration.
My epigenetic biological age is 51 years ā¦ actual age 64 years. GlycanAge is 37 years. Works for me.
Also, I take 1 pill of anastrozole per week with my shot to balance my male estradiol which is in the perfect level - not too much not too little for the past 3-years.
It works for me.
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David
#9
Thank you for sharing. It would make sense that a balance of turning on and off mTOR would be ideal. I do a similar regime, but without the anastrozole. Just started the Rapamycin 2 months ago and enjoying some of the changes.
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This just in todayā¦ my GlycanAge results.
Looks like it is working. Yeah!
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DrRoss
#11
Hi Mac,
I do both: IM testosterone once weekly and 6 mg rapamycin/sirolimus once weeklyā¦seems like a no-brainer to me.
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One Year Of Testosterone Therapy For Men With Low Levels Of The Hormone Appears Not To Increase Risk For Heart Problems, Meta-Analysis Concludes
HealthDay (6/9) reports, āOne year of testosterone therapy for men with low levels of the hormone does not appear to increase their risk for heart problems,ā researchers concluded in findings presented at an Endocrine Society meeting and simultaneously published online in The Lancet Healthy Longevity journal.
Healio (6/9) reports investigators arrived at this conclusion after they āconducted a meta-analysis of 35 studiesā¦of testosterone vs. placebo for hypogonadism including 5,601 participants.ā
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The Huberman / Attia podcast recently covered a lot of ground on Testosterone replacement for men (and estradiol for women). Highly recommend it if you are interested in this. I have never followed this area of research as I donāt believe it has much of an impact on longevity (but it seems it does help guys get more things doneā¦ from what Peter Attia says) - which may be useful in terms of quality of life. The video below is queued up to start at the testosterone discussion.
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Agetron
#14
Great find-- the TRT information is solid. An added treat is the section that follows on Cholesterol and LDL-C. Nice!
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As you adjust your TRT dose, keep this in mind 
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Agetron
#16
Hahahaā¦ my thoughts before I started TRT.
Truthā¦ in my humble opinionā¦if you are 60 or olderā¦ rapamycin and TRT make a rocking combination for muscle, bone, energy and mental euphoria. But you need to do a consistent ā¦ regular solid workout ā¦ as Dr. Attia says in the podcastā¦ or it does nothing for you.
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How much T are you taking Jason?
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Agetron
#18
Once weeklyā¦1ml of 200 mg Cypionate ā¦inter muscular injection in thigh.
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Peter Attia says in the Podcast above (1:56) that itās rare his patients go above 100mg per week (āthe highest weāve ever had to go is 70mg twice per weekā). Are you concerned about the longer term side effects of supra physiological doses?
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MAC
#20
Chiming in, I take 100 mg/week, split two biweekly injections of enanthate. Attia talks very specifically about getting free T to 2% of total T. My last panel, my free was 1.8%.
My doc has taken my free T to around 550, like a 25 yr old. Hardly āsupraā doses.
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