Rapamycin + Metformin

[curt504]

@desertshores

taking 500mg in the evening

@desertshores and I see others are taking metformin in the PM. Any reasoning for not AM and in the PM?

Tnx curt

[desertshores]

It depends on how much metformin you are taking. If you are taking more than 500 mg of metformin, I would divide the dose.
My 500 mg prescription says evening.

[DeStrider]

I take mine in the evening as well. When I was taking 1 g, I split the dose between morning and night. I actually switched to Metformin XR which slowly releases metformin throughout the day in order to avoid GI issues. It’s a little more expensive though.

[adriank]

I had a strange reaction between jardiance and metformin… Might just be a coincidence. I’ll restart tonight with 500mg xr. My cgm does not go below 5…

[AustraliaLongevity]

Something I don’t see others stating in this thread is metformin helping with asthma.

• Most studies show reduced asthma exacerbations (fewer ER visits and hospitalizations) in people taking metformin.
• Benefits are likely due to anti-inflammatory effects via AMPK activation, not just blood sugar control.
• Animal studies support this too, showing reduced airway inflammation and remodelling.
• GLP-1 agonists may further enhance asthma control when added to metformin.
• SGLT2 inhibitors perform similarly to metformin, while DPP-4 inhibitors may be less helpful or even worsen asthma control.
• No studies in my review showed harm from metformin in asthma patients. Only one showed mixed results and called for more research.

I Reviewed 15 Studies on Metformin and Asthma — Here’s What I Found

I reviewed a wide range of studies on metformin and its impact on asthma. The overall consensus is strongly positive, especially in people with asthma who also have diabetes, obesity, or metabolic dysfunction. Most studies show reduced asthma exacerbations (fewer ER visits and hospitalizations) in people taking metformin. Benefits are likely due to anti-inflammatory effects via AMPK activation, not just blood sugar control. Animal studies support this too, showing reduced airway inflammation and remodelling. GLP-1 agonists may further enhance asthma control when added to metformin. SGLT2 inhibitors perform similarly to metformin, while DPP-4 inhibitors may be less helpful or even worsen asthma control. No studies in my review showed harm from metformin in asthma patients. Only one showed mixed results and called for more research. As a side note: I went looking into this completely neutral to any particular outcome. I’ve not been that impressed with metformin for longevity from …

[AustraliaLongevity]

Does that include sustained release versions?

@RapAdmin

Well, Metformin for longevity has finally hit Vogue magazine

Vogue and L’Oreal were not on my longevity bingo card. This is why you don’t gamble.

[desertshores]

@AustraliaLongevity

**Benefits are likely due to anti-inflammatory effects via AMPK activation.

There are many drugs and supplements that have anti-inflammatory effects via AMP activation, from aspirin to quercetin.
Oddly, after decades of taking metformin, I began having diarrhea after taking it, even in the extended-release form, so I am no longer taking it.

[AustraliaLongevity]

We’ll see how I go with it.

[AustraliaLongevity]

“The paper also highlights other relevant pathways: inhibition of NF-κB signalling, suppression of vascular smooth muscle cell senescence, reductions in reactive oxygen species and improved lipid handling via PCSK9 modulation. These mechanisms appear to converge on structural benefits – reduced arterial stiffness, slower plaque formation and improved endothelial integrity – all early markers of vascular aging with known links to mortality”

Metformin steps into the vascular aging spotlight