#81

Rapamycin and Metformin (or Acarbose) - the synergistic longevity combo! I love it!

#82

I take Rapa at 6mg a week on a Monday morning. I take 500mg of Metformin in the morning, and again another 500mg at night (before my meals).

#83

Trendsetting. Best to stock up, price will skyrocket when it goes mainstream :stuck_out_tongue_winking_eye:

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#84

I take 2.125mgs of immediate release metformin everyday, 850mg tablets split in two, so 425mg taken throughout the day. I do find it doesnā€™t do my VO2max a lot of good. :frowning:

ā€¦and for the record, Iā€™m not a diabetic and just take it for longevity purposes.

#85

ā€œWhile biotech companies are tight-lipped on their research into reprogramming cells, many in the industry posit that the future of aging wonā€™t look all that different from traditional medicineā€

Very interesting article and this phrase hit home so to speak. Not a believer in the reprogramming of cells. IMO that will be another resveratrol or NMN.

#86

@Agetron @desertshores @RapAdmin @Walter_Brown at al, Is anyone taking Metformin for longevity purposes only and What would you guys suggest as a dose for metformin for someone who doesnā€™t have the risk of diabetes, basically to take for longevity only (i.e. telomere length protection and enzyme activation)? I currently do 500mg before bed, but thinking of adding another 500mg with my first meal of the day, usually lunch, sometimes dinner.

btw, i do take Acarbose with meals (as of late) usually at 50mg or 100mg if lots of carbs.

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#87

Hi @SNK , I take it for longevity purposes only. 500mg morning and night. I also take Arcabose with evening meal and take Canagliflozin with my morning Metformin.

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#88

Thanks for your reply and help. Do you have any (significant) side effects you can report on, It seems you are taking quite a bit of the anti-diabetes drugs. My only concern is in theory there comes a point where the side effects (known and maybe unknown) might blunt the benefits. From what I have read the main benefits of these drugs (for longevity) seems to come from flattening of the glucose spikes, or keeping glucose levels somewhat constant. Therefore, I wonder if we might overdue or underdo with the dosages and the variety of drugs(for example, if you take Metformin then why also Canagliflozin, and or Acarbose).

#89

Not that I can tell. I exercise 3-5 times a week. I take so many because they have different ā€˜sideā€™ or ā€˜off labelā€™ benefits. For example, Canagliflozin is neuroprotective and increases the levels of Klotho protein in the brain. Iā€™m keen to protect my brain.

Iā€™m in remission with multiple sclerosis and biohack myself as Iā€™m trying to remyelinate and reverse lingering damage from when my disease was active. So I read a lot of journal articles (ScienceDirect is a good source) and then apply them experimentally on myself. I am not advocating anyone follow my example :slight_smile:

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#90

Great info. I wasnā€™t even aware of this. Bookmarked the post. Thanks,

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#91

Here is a good article with free text access too. Enjoy :slight_smile:

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#92

I took metformin, 500 mg/daily for decades, mainly for glucose control. I wasnā€™t pre-diabetic, but I wanted to lower my fasting glucose. In the last two years, I have been on and off of it.
Why? Because there was a big debate on the merits of metformin in this forum and other places. I think the preponderance of the evidence is that metformin has merit other than just lowering glucose levels. I am currently taking 500mg in the evening.

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#93

See this TAME trial overview.

Metformin dose: 1500 mg slow release 1x per day

MP-Justice.pdf (2.9 MB)

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#94

Metformin slow release gave me skin rash. Did anybody have a similar reaction?

#95

I had a higher reading on my A1C after a blood test about 1.5 years agoā€¦ I asked my doctor if I could take Metformin for it and he said yes. (I only wanted to take it because of the interviews that I watched from Dr. Sinclair)

The blood tests that I have taken after the Metformin had little change. Maybe because I was a carb addictā€¦ I am still taking itā€¦

I have been having some trouble getting a full night of sleep as I wake up after 3-4 hours after going to bed. I started trying to eliminate the variables and Metformin was one of them. I was taking it right before going to bed. I donā€™t think it interferes with sleep as I woke up after ~4hrsā€¦

But the interesting thing was when I took it in the morning. I played Pickleball a few hours after taking it and I was struggling to catch my breath the entire match. I needed to take breaks between games which I usually do not need. It was like my muscles had a limited amount of oxygen going to them which made me push more than necessary when sprinting around the court. It was hard to recover between points and it seemed that my heartrate would not come downā€¦

In this paper from Nature, Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells, it states " Experiments in isolated hepatocytes demonstrated that high concentrations of metformin inhibited mitochondrial oxygen consumption , through suppressing complex I of the electron transport chain7."

I remember hearing Dr. Sinclair state that if he is going to exercise the next day, he skips taking Metformin. (If I remember correctly).

I never really gave it much thought about it affecting my athletic performance, but I now have a real life experience with it. Guess I will keep taking it in the evening, but a few hours before bed or with dinner.

I just started taking Rapa, so Iā€™m not 100% sure of the combination of moleculesā€¦ I need to read up on the info earlier in this threadā€¦

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#96

Do we have anything more recent on this?

Paper highlights:

Summary:

Metformin, primarily used for treating type II diabetes, has shown potential in cancer treatment and prevention. It works by:

  • Inhibiting mTOR: Through activating ATM, LKB1, and AMPK, it reduces protein synthesis and cell growth.

  • Activating p53: Via AMPK, it can halt the cell cycle.

Benefits in Cancer:

  1. Prevention: Reduces the incidence of various cancers.

  2. Mortality: Lowers cancer-related death rates.

  3. Treatment Enhancement: Improves effectiveness of radiotherapy, chemotherapy, and androgen deprivation therapy (ADT).

  4. Tumor Behavior: May reduce tumor malignancy and movement.

  5. Recurrence: Decreases the chance of cancer relapse.

  6. Side Effects Reduction: Mitigates adverse effects of ADT.

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#97

What else you are taking for neuroprotection?

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#98

Metformin, galantamine, simvostatin would be on the list but I think other items in my stack probably confer neuroprotection.

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#99

Metformin interferes with lactic acid???

Any opinions??

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#100

Attia is no doubt a good guy, well meaning but misses a few benefits (IMHO). And is a bit too "STD of care-ish for me. I took Attias advice and crossed metformin off my list of go buy a large stash to add to my antiaging list (bushel basket). And was ignoring the body builders avid use of metformin that they pair with SGLT2, GLP-1, TRT (testosterone therapy), mitocondria boosters, fat mobilizers. Quite an amazing rise from just anabolics and huge testosterone use.

THEN: Alex Kikel et al, [ https://www.youtube.com/results?search_query=alex+kikel+peptides ] in his 200mph whirlwind health talks (along with Hunter Williams/Jay Campbell) the value of metformin blabla. Then I changed my mind on an Alex Kikel comment that metformin rejuvenates the thymus and boosts mitochondria!!! Attia (or someone in the Allopathic world) said metformin suppresses or is toxic to mitochondria and I took it at that.

IMHO the thymus back to 100% is the anti-aging hole grail. I take HGH secretagogs (boosts) Ipamorlan and Tesamorlan first thing AM. Injected peptides to boost thymus function. There is no easy measure of the thymus function. One thymus boosting companyā€™s rep on youtube said measuring immature T cells (??) before and afterā€¦

But: Google Search

    • Studies in mice have demonstrated that metformin can alleviate thymus degeneration and improve mitochondrial function.

Also from the body builders: https://www.youtube.com/watch?v=TGlDV1ZpKco

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Ok Just sharing my flipping from once a proponent, then not interested, back to very interested. When I was taking 500mg/AM I had no digestive issues. Some do.

Re lactic acid running higher after intense exercise. #1 this is only after intense exercise, I believe. #2 for some reason very credible health folks donā€™t consider this a negative. #3 possibly higher lactic acid is just a hormetic that actually is not entirely bad. Yes for some taking metformin does reduce / block muscle growth, for only some. Some health folks cycle metformin on refeeding/growth days and not on work out days. Iā€™d be in the 5-6 days a week camp.

Some wise health coaches advise cycling ALL nutricals, not just peptides and some nootrophics (phenylparacitam, modafinil etc). So Sunday is my no nutricals day. And less on Saturday. Back to a bushel on M-F.

I tip us older folks to grow/keep muscle via the kaatsu.com bands. Iā€™m happy with our two C4ā€™s. Spousal compition (and complaining) got so bad I bought a 2nd C4. LOL

Take care, curt

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