Those with pre-diabetes I consider “at risk”.
AnUser
#65
And how do you know those with pre-diabetes were those who got diabetes from rosuvastatin compared with atorvastatin and not people in general?
There is also an increase risk in cataract surgery according to this study.
Alpha
#66
Why not take Berberine with Rapamycin?
I’ve tried grapefruit and grapefruit juice, but have always had concerns about having access to a standardized|repeatable dose relative to its amplification of Rapamycin. If we had at home monitors of Rapamycin levels one could adjust.
So, this leads me to consider Berberine.
How effectively does Berberine inhibit CYP3A4?
Could one safely|reasonable take enough Berberine to get a 3X to 5X multiple similar to grapefruit juice?
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I supplement daily with berberine and curcumin, but i take rapamycin 3 hours earlier with a pomelo.
On dietary CYP3A4 inhibition:
As I researched foods that might inhibit CYP3A4, besides grapefruit, I was surprised to learn that many healthy foods—which I assume many of us eat—might have this effect, though not as strongly; But the data seems limited. For example:
Initially, I planned to avoid any CYP3A4-inhibiting foods on the day I take rapamycin. However, I now wonder if consuming many of these healthy foods might allow me to use a slightly lower dosage (e.g., 4 or 5 instead of 6mg).
The challenge, of course, is that it seems almost impossible to quantify the magnitude of inhibition and the effect on rapamycin’s efficacy, ensuring I’m neither getting too little nor too much—especially when eating so many different foods. So I don’t know if it’s possible to pick the right dosage.
What do you think, have you experimented with these weaker inhibitors (not grapefruit)?
EDIT: Correction:
Ashwagandha and quercetin actually appear to be CYP3A4 inducers. So would that imply that they would have the opposite effect (potentially decrease rapamycin effects or necessitate a higher dosage)?
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I did read something on timing. I don’t have it to hand but with either grapefruit or pomelo you needed to eat the fruit at the same rime or up to a couple of hours earlier to have the effect. If you take rapamycin 2-3 hours before the other the effect is reduced.
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I recall reading that 2-3 hours before is best with an effect up to 12 hours before. Eating it afterwards would make no difference is my understanding.
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Wine consumption is fine while on Rapamycin medication, that’s something new I’m reading. While moderate alcohol consumption may not directly interact with Rapamycin, it’s always essential to consult your healthcare provider about any potential interactions or effects, as alcohol can affect the body in various ways and may not be advisable for everyone, especially when taking any kind of medication.
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The thing about Grapefruit/Pomelo etc is that it prevents your intestinal enzymes from breaking down as much of the molecule as would normally be the case.
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Anyone recommend a brand of citrus bergamot that you trust?
umi
#74
But it’s combined with turmeric…
Andrea
#75
Just saw this edit and went to the Wikipedia site. It looks like quercetin is listed in both columns??
I am taking EMIQ (enzymatically modified isoquercetin) which is 40x the absorption of standard quercetin, and haven’t begun taking rapamycin yet. I take 100mg EMIQ twice a day as a mast cell stabilizer, and after reading up on rapamycin, I’ve been interested in trying it to treat my high IgE, multiple food allergies, likely MCAS, hormonal imbalance, and autoimmunity.
Planning to start low (especially considering this thread, with all the contradictions listed), probably 1mg a week?
Any input?
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Curious
#77
Does coffee interact with Rapamycin? This morning I had two triple espressos, and after 150 minutes I had 6 mg Rapamune. And anecdotally, I felt more great than usual after my dose of rapmune. .
I would like to hear from members who can share anecdotal experiences from drinking Coffee and taking Rapamycin. I know that some other members here also feel great after taking the weekly or biweekly Rapamycin. Today I got an amplification of that effect, which startled my curiosity. Placebo?
So far, I have not found research that makes me think that coffee affects CYP3A4 negatively. I have only found rather old research done on cells and primitive organisms.
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From your paper:
“ Unmodified caffeine downregulated mTOR signalling”
The gym bros will not be happy with this finding.
Still, caffeine before exercise is a fundamental practice for me. Caffeine improves fat metabolism ….is the traditional thinking.
Green tea with rapamycin is my normal protocol but that’s not for the caffeine. I also do coffee when I’m fasting which I usually do on a rapa day. I’ve not heard of caffeine and rapa interacting but they may act on similar pathways and add to the effect.
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Curious
#79
Yes, Whenever I see a study that shows some kind of effect, I ask myself if it is relevant and might have a meaningful effect in the complex human biology. If caffeine inhibits mTOR, I don’t see it as something that has an effect worth considering. But caffeine is performance enhancing and use it before running (but not before going to the gym).
Next time I take my rapamycin I will take it after drinking coffee, as I did today. To see if I get the same effect as I did today (increased mental clarity/mood) or if I should place today’s experience in the placebo category.
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Thor1
#80
I would love to ‘feel great’ after taking Rapa! I had to take it on my down running day. Then switcihed to taking it at night and sleeping through the slug-like effects. Then finally stopped taking it. I was only on a 2.5mg dose. I am thinking of starting again so am interested in how to ‘feel great’ when taking rapo. I will happily drink espresso!!!
Genja
#81
Theobromine is a far more potent mToR suppressor than caffeine, adjusting for how much one receives in a mildly stimalutory dose of chocolate as compared to how caffeine one would need for similar stimulation. And yes I know chocolate also contains caffeine.
