Rapamycin for Hair Growth and Hair Pigmentation

[Agetron]

As long as I get Fabio Hair - the extra bit of pills is no biggie - LOL.

I must say my hair is pretty damn silky feeling as of late, and seems to be a lot healthier…less silver/grey more blonde-brown. Was in Florida at the beach for a week-- the salt-water, sun and heat/dryness really abused my hair. So it was a little setback, but back on solid grown again.

[Agetron]

I take a 5mg finasteride pill every other day - and have since I was a bout 32 years old. My Urologist says my prostrate is that of a 28 year old. Keeps me on it. Same guy who said guys 60 + should be on a daily small dose of tadalafil (2mg).

[MAC]

@Agetron

As long as I get Fabio Hair

As good a longevity biomarker as any!!

[jakexb]

Are you all using the topical once per week along with your oral dose? Or are you using the topical every day?

[Agetron]

Good question.

I am using the low oral dose of minoxidil daily 2.5 mg pills (2 pills) = 5mg.

I use my topical soultion on front and crown at bed time… and again after I wash my hair in the morning… twixe a day as recommended.

Getting solid results

[Stazio]

This is not about hair regrowth but hair repigmentation, I started with Dr Green a few years ago at 3mg weekly, that is now ramped up to 10mg weekly. I have had several weeks where I skipped a dose and then done 20mg with a two week rest interval. About a year and a half into the Rapa, I noticed that my pubic hair went from mostly white to completely black. Then my chest hair turned black. Now my head hair is turning black (currently salt and pepper from white).

Rapa is the only thing I’m doing that I can associate with this outcome. I’ve been low carb/keto for years while the depigmentation was progressing.

[RapAdmin]

Hi - and welcome to the forums. Is there any way you can post some photos pre and post results? It would be great to see the results.

So - -you are only doing oral consumption of rapamycin, is that right? No topical applications?

[Agetron]

YOU WROTE:
I noticed that my pubic hair went from mostly white to completely black.

Yes… pics please… LOL…

Nooo… no… just kidding! Hahaha

Rapamycin tends to make me euphoric and inappropriately youthful in my thoughts, humor and my responses sometimes.

[jakexb]

Love to see reports of hair repigmenting. So much of rapamycin is about playing the long game and hoping to see benefits years down the line, so it’s great to very objective changes happening in the short term.

[desertshores]

Please, forum members, share your results from taking rapamycin for a few months or more, both subjective and objective. negative and positive.

These are some, but may not be a complete list of my personal results after 8+ months.

Positive:

Very improved skin condition.

Complete eradication of actinic keratoses

Greatly improved sleep, after about 7 months.

Improved feeling of well-being.

Lowered blood pressure: Last 5 days, morning measurements.

Blood Pressure
Systolic mmHg	Diastolic mmHg
112	61
117	62
109	55
113	69
117	65

Lowered resting heart rate. Currently, 48 to 56 bpm, depending if I take the measurement before or after my first cup of coffee.

Negative:

Increased cholesterol levels.

Tiredness on the day after a large dose.

Very slow wound healing of small cuts that occurred in the week following a high dose.

Some thinning of finger and toenails.

Diarrhea if the dose is too high.

No reduction in age was calculated using the Levine-derived spreadsheet markers.

Undetermined, good or bad, I don’t know. I guess it depends on who you are.

From a previous post:

“I didn’t expect a loss of weight due to a loss of appetite and a decreased resting heart rate. I now have to force myself to eat enough to keep from going below my recommended weight range”

No measurable change in fasting glucose. Lastest test. 98mg/L, HEMOGLOBIN A1c, 5.2%

Examined my privates today: Still gray

[Agetron]

Ran out of my hair tonic. Sooooo… I whipped up a new batch of 4 fluid ounces…
Lasts about 3 weeks using 3 full eye droppers worth - front – top – back of crown; apply after morning shower and again at bedtime.

Pictures here are the ingredients to make 4 fluid ounces. Crushed with needled nose pliers – take 5 pills of 500 mg metformin; 3 pills of 2 mg sirolimus; 4 pills of 5mg finasteride. Then have all crushed pills soak in 1 fluid ounce of no scent DMSO for one hour stirring every 10 minutes - this just dissolves them… the DMSO… makes the tonic permeate the skin; last add 3 fluid ounces of Minoxidil 5% solution. Mix it all thoroughly and pour into a dark glass bottle. Always shake the tonic before use - applying with an eye dropper.

So here was my front – top crown on May 1, 2022. OMG!

And pics that I just took a few minutes ago!

Definitely thicker throughout and very soft and silky to the touch!

Going to keep at it for now. Pretty cheap and I have the extra pills. I am guessing everyone on here has some degree of hair loss. We can slow aging with rapamycin… maybe my tonic slows hair loss. Would just using 5% Minoxidil be sufficient? Not for me - I tried it for years with poor results - my hair was brittle (looked chalky) and the new hair never really came in full.

FROM GQ: One-fifth of men will experience significant hair loss by age of 20, and that percentage grows proportional to age. Bauman says that significant loss increases steadily with age: 30 percent will experience it in their 30s, 40 percent in 40s, 50 percent in 50’s and so on. “This math proves true for men into their 90s,” he says. “If you go unchecked but have maintained most of your hair by middle age, then your sensitivity to DHT is probably on the low side, meaning you have a slower rate of male pattern hair loss going on.”

[desertshores]

Yeh, yeh, so you got some hair.

You might consider using diethylene glycol monoethyl ether, also known as Ethoxydiglycol.

It is a penetration enhancer that goes deep into the skin but does not enter the bloodstream.

I was using DMSO until I found this. I use it in my rapamycin lotion.

It is much more pleasant than DMSO. I have touted DMSO in the past but I have made the switch.

It’s available from Lotioncrafter for $11.75 for an 8-ounce bottle

Dermatologists are already treating patients that apply products containing 5–40% of this solvent multiple times each day.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2165.2011.00590.x

[Agetron]

Thanks for the option. My DMSO is ordor free. Will use until I run out.

[Vlasko]

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded...

[MAC]

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded...

Amazing!

I think Agetron might be on to something. Quick, file a provisional patent, and run with it!

[RapAdmin]

Wow - I first thought this was just a paper about microneedles as a delivery vector, but I see now its also about rapamycin - fantastic results!

Were do I buy my transdermal, dissolvable microneedles?

[MAC]

@RapAdmin

Were do I buy my transdermal, dissolvable microneedles?

Forget micro-needles…topical rapamycin is plenty boost! Look at purple line, upside down triangle.

OK, we’ve moved the rapamycin “needle” forward a bit…thanks Agetron.

[RapAdmin]

@MAC

Forget micro-needles…topical rapamycin is plenty boost! Look at purple line, upside down triangle.

True - definitely a very good start!

[Agetron]

Thanks MAC.

Talk is talk… the proof is in the hair growth. Lol
The DMSO… does the permeation.

[MAC]

@Agetron

Talk is talk… the proof is in the hair growth. Lol

You need a silent investor, let’s talk…

You’ve singlehandedly done more to promote Rapamycin for real world translatable human benefit than MK/MB combined.