#103

This is a very interesting thread, thank you.

I read it from start to finish but could not get a clear picture on the recommended dosages for:

amla extract;
gotu kola;
pine bark extract

Should these be taken with or without food, AM or PM?

I tend to be hypersensitive to supplements ( they can affect my sleep), so just wanting to minimise potential side effects.

Thanks!

#104

From the above post papers titled;

“A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia,”

Amla extract 500mg was administered

These doses from the Joel Kahn article{pages 37 to 40] also included aspirin.

Aspirin - 100mg a day
pine bark extract{French Maritime Pine Bark Extract was used] - 150mg a day
gotu kola - 450mg a day

2 Likes
#105

From davin8r: True Capros Amla 500 mg twice a day
From brandy: French maritime pine bark. I use about 300-500 mg
I use Nature’s Answer gotu kola

Maybe all after a meal.

2 Likes
#106

I’ve sort of soured on aspirin for primary prevention since the data doesn’t seem to be there. Not sure if he’s still using it.

4 Likes
#107

Yikes!!
Like I keep repeating, this lipid stuff is complicated and by no means do we have all of the answers.

1 Like
#108

rivasp12,

What was the dose?

Which brand?

#109

My LDL has gone down from almost 70 to 30 since taking Rapa. Full disclosure, I’m also taking all kinds of other stuff (Gotu Kola, Pine Bark extract, vitamin D/ K2, etc).

My fasting glucose is also fine (70’s range). A1C is 4.9.

I’ve been on Rapa for about a year. Started at 3mg/ week titrating up over time to current (last four months) of 6mg with grapefruit juice every two weeks (approx equivalent of 20 mg).

5 Likes
#110

A whopping 45,000 mcg only found at life extension website.

1 Like
#111

Those are some excellent numbers. Do you feel better in any way since starting it?

#112

@Joseph thank you, that is very helpful.

#113

Well I feel great but I have a pretty significant plaque burden (590 CAC score) so I am obsessed with any protocol that can slow down that progression. Now all my lipids look great.

1 Like
#114

So @Pestodude you don’t currently (and haven’t in the past?) taken any statins or PCSK9 inhibitors to get your cholesterol / APO-B down?

You’ve gotten it down to that level just with the supplements you mentioned?

Also - I have a more general question (for everyone on this topic) - when you do your fasting blood test and check your cholesterol and APO-B levels - I’m assuming that the last day you took any supplements or statins/PCSK9 inhibitors, etc. are the day before the blood test - so its been 12+ hours since any of the supplements or medicines have been taken - is that right?

Does anyone stop taking the supplements or medications longer than one day prior to the blood test for any reason (e.g. get a better read on what your current lipid levels would be without any add-ons that may be lowering it, etc.?)

#115

Sorry, yes I have taken 10mg Crestor for several years. No PSK9 inhibitors. Also changed my diet, very low carb, eliminated sugar, one meal a day (most days).
Always do my labs prior to taking meds.

1 Like
#116

Are you keto…confirmed with blood ketone measurements?

Can I ask what is the rest of your diet macros, protein/fat/carbs?

Sugar is a CLASS 1 TOXIN.

#117

Not keto. Closer to a “Mediterranean diet”. Probably eat more protein than is considered best for longevity but I’m almost 65 and want to stave off sarcopenia. I lift 6 days a week and do zone 2 cardio 4-5 days a week and zone 5 cardio once or twice a week.

#118

Keep pumping that iron!! Endurance does not build muscle, but helps keep tone/preserve.

You can crush sarcopenia with muscle build reserve, but the window (without any pharma intervention) in older age, is 60-75.

A skeletal muscle talk from ARDD 2021

Loss of skeletal muscle with aging and the adaptability to training - it is never too late

Screen Shot 2022-05-20 at 8.21.08 PM
Screen Shot 2022-05-20 at 8.21.08 PM1920×1351 158 KB

1 Like
#119

I do cardio for cardiovascular purposes/ improve V02 Max.

Thanks for the article. I’ll check it out.

#120

Check here for NAC: https://www.swansonvitamins.com/q?kw=n%20acetyl%20cysteine

#121

Do you have any idea how much each group of medicines / supplements lowered your cholesterol?

I’m just curious - if you were at 200mg/dl before you started, and are at 30 now - was most of that (e.g. 70% from Crestor and the rest the supplements)? Just curious how effective the supplements have been compared to Crestor…

#122

Just in terms of side effects, after one week of Amla extract at 500 twice a day, no side effects whatsoever. This is in comparison to the several times that I’ve experimented with statins wherein I would have fatigue and muscle aches after one week. I’m assuming that this is related to CoQ 10.