Rapamycin and risk of cardiovascular disease

[desertshores]

Generic statins are very cheap.
My co-pay for statins is zero.
Insurance companies believe statins are a good investment.

[Bicep]

Great article !! Could have been written by Malcolm Kindrick, pretty much sums up his book. Thanks,

[rivasp12]

It helps to explain how viagra, which increases endothelial nitric oxide levels, a natural anticoagulant, leads to a decreased risk of CVD.

This can also be achievable through arginine and pine bark extract.

The role of vitamin c was also interesting. Might be a good idea to check for fibrinogen levels.

[Agetron]

desertshores …My co-pay for statins is zero.
Insurance companies believe statins are a good investment.

Lol… you question doing TRT, but not about taking statins???

M. Kaeberlein and P. Attia having nothing good to say about statins in their podcast together. Or even if they work at all. Just sayin!

[zazim]

My blood sugar has definitely risen. I don’t know if it is due to rapamycin or changes to my diet. Tomorrow I will finally get to a full 6 mg dose. I will also watch my carbs in the next week and see what happens.

I do not want to lose any weight. Not a single pound. But I still am going to do five-day water fasts periodically.

[MAC]

@Bicep

Great article !! Could have been written by Malcolm Kindrick, pretty much sums up his book. Thanks,

It was written by Malcolm.

[Bicep]

Lol, that explains it.

[Deeinflorida]

I had a Cologuard test. a year ago, tested positive , decided not to have a colonoscopy as I was pretty sure the positive result was due to a small hemorrhoid , (had rectal ozone therapy)
A year later, I feel great. If it ain’t broke, don’t fix it

[Deeinflorida]

How much higher is your blood glucose? Mine jumped up 45 points the first time, I only take 3 mg a week, I missed a week and glucose went back to normal

[Bicep]

@rivasp12

The role of vitamin c was also interesting. Might be a good idea to check for fibrinogen levels.

I’m learning that these things have multiple roles that are poorly understood by me anyway. I used to take massive amounts of vitamin C (even got 2 kidney stones). Then Chris Masterjohn explained that vitamin C has to be charged up by glutathione, and when you take a lot of it the glutathione gets run down and leaves you unprotected. Which is how it becomes an oxidant when given IV. And why it works for Cancer. But it also works as a substitute for Lp(a) and low levels of C will increase Lp(a). Which is what Linus Pauling said back in the 1990s.

I always thought fibrinogen was a bad thing, after my uncle’s stroke. And sought ways to reduce it, including Nattokinase. Then Lustgarten’s book quoted this study:
https://www.pnas.org/doi/abs/10.1073/pnas.2009837118

And it appears that fibrinogen helps kill off the microbial burden.

[Deeinflorida]

Would it be better to grow the broccoli sprouts instead?

[MAC]

@Bicep

I’m learning that these things have multiple roles that are poorly understood by me anyway

Understatement of the day! We know so little…

[desertshores]

That would be a yes.
I do not question that TRT has some benefits, but only if your testosterone levels are low.
I do not understand doing TRT if your testosterone was in the normal range before you started.

FWIW: My doctor absolutely dismissed TRT when I asked him about it because my T was in the normal range.

Did you have low T or did you just want to build bigger muscles?
At my gym, there are two groups of bodybuilders; “natural” and “roid” users.
But. IMO TRT has far bigger risks than statins.
“TRT may increase the risk of cardiovascular events in aging men with low testosterone levels, particularly in the first 2 years of use. In the absence of identifiable causes of hypogonadism, TRT should be initiated with caution among aging men with low testosterone levels.”

Table 3
Potential risks for testosterone replacement therapy:
Stimulate growth of prostate cancer and breast cancer
Worsen symptoms of benign prostatic hypertrophy
Cause liver toxicity and liver tumor
Cause gynecomastia
Cause erythrocytosis
Cause testicular atrophy and infertility
Cause skin diseases
Cause or exacerbate sleep apnea

The benefits and risks of testosterone replacement therapy: a review

Testosterone is an anabolic steroid.
The main anabolic steroid hormone produced by your body is testosterone.

“Taking anabolic-androgenic steroids to enhance athletic performance is prohibited by most sports organizations — and it’s illegal. In the past 20 years, more-effective law enforcement in the United States has pushed much of the illegal steroid industry into the black market.”
Performance-enhancing drugs: Know the risks - Mayo Clinic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/Although many retrospective studies

" some retrospective studies of prescription databases have shown a higher risk of cardiovascular events in men receiving testosterone."

https://www.nature.com/articles/s41569-019-0211-4

[MAC]

@Deeinflorida

I had a Cologuard test. a year ago, tested positive , decided not to have a colonoscopy as I was pretty sure the positive result was due to a small hemorrhoid , (had rectal ozone therapy)
A year later, I feel great. If it ain’t broke, don’t fix it

Not sure I follow…you tested positive, yet you think because you’re asymptomatic, you are thus cancer free?

[Deeinflorida]

Hi in what way has Rapamycin changed your life and what is your protocol?
Thank you

[约瑟夫]

@rivasp12

“This can also be achievable through arginine and pine bark extract.”

Any reference and or dosing information?

[RapAdmin]

Getting back to the topic of this thread - Rapamycin and CVD, a paper from 2020:

Watch the video in the paper linked to below…

In humans, the clinical applications of rapamycin including the elution with rapamycin stent have shown many adverse side effects such as stomatitis, myocardial infarction, heart failure, and hypotension. Although reports of side effects to blood vessels are not well known, adequate caution is required for the clinical application of rapamycin. From the results of our study, we propose that rapamycin should be used in combination with an early-stage autophagy inhibitor, which is not involved in lysosome inhibition, and that other SASP inhibitors need to be developed to prevent aging-related vascular diseases.

Rapamycin promotes endothelial–mesenchymal transition during stress-induced...

[desertshores]

@RapAdmin

Getting back to the topic of this thread

“Getting back to the topic of this thread”
I totally agree. The posts should follow the use of rapamycin primarily and other “life-extending” supplements.

[rivasp12]

A good dosing for endothelial NO response is 3 grams of arginine with 120mg pine bark

https://journals.sagepub.com/doi/pdf/10.1177/2631831818822018

Personally, I like 500 mg pine bark and I also take grape seed extract.

[rivasp12]

The possibility of rapamycin having a deleterious effect on endothelial function is certainly a concern. It’s reassuring that heart transplants on rapamycin have less cardiovascular risk. Several studies in mice show clear anti atherosclerosis properties. Rapamycin also improves cardiac function.
Let’s also not forget that Alan Green has been treating very elderly people with rapamycin for several years now and he’s not reporting a slew of cardiac events. Patients with stents already have severe cardiovascular disease and poor endothelial function.

Here’s a good discussion on this topic.

Effect of rapamycin on aging and age-related diseases—past and future -...

I’m certainly not going to combine an autophagy inhibitor with rapamycin regardless of their recommendation.