#810

I understand that but I’m very hesitant about almost all drugs, but especially those that are fairly recent.
I can’t tell you how many times over the past 40 years that I’ve seen, and continue to see, side effects pop up after a drug has been out long enough or has been used by a large number of people. The examples of this are multiple .

I’ll take some cinnamon extract and chance the glycemic index.
But that’s just me.

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#811

The senolytic effects of Grape Seed Extract have been discussed also in some research.

#812

A reduced production of insulin will not necessarily mean that your blood glucose levels will rise as long as you are not insulin resistant. I can’t tell if you guys are just looking at A1c tests or wearing a CGM. I do know that once I started taking rapamycin I thought that my new CGM was defective because the readings were higher than normal. I will be interested to see what happens with the next set of monitors.

#813

I was only taking 3 mg a week for 4 weeks , I was also taking Metformin but it didn’t help

#814

145 is pretty high. Do you use a finger stick or CGM? Or just go to the doctor and get a fasting? Maybe you got it on a bad day.

Just my opinion but Rapa is a maybe on people. I take it for the arthritis and brain fog. I hope it makes me live longer, but I’m not counting on it.

High blood sugar is a sign of insulin resistance and bad things are happening. I went Keto and started running 2 miles, 5 or 6 days a week. Not fast at first and not so many days a week at first. The main thing is to work at a heart rate of about 125 for a half hour or so. The keto flu is a pain in the butt, and tough to push through. Your body needs to get used to burning fat. It takes a while. It won’t like this. I’d say there are probably a bunch of new drugs that would work great, but I’d try the hard way first.

I’m still not a doctor.

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#815

Thank you for your response. However prior to taking rapamycin, my blood glucose level was between 95 and 110, which was fine. I am unable to exercise outside due to the heat and humidity in Florida. However I do manage to play golf two or three times a week at 7 AM. Regarding weight loss, I do not need to lose weight as my weight is perfect. I’ll and now being more careful about what I eat and I am not taking rapamycin for the time being until I can see my glucose level getting back to normal. I’ll check my blood sugar level at home, and I do labs every three months

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#816

In case you missed it, Costco has their glucosamine/ chondroitin on sale now.

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#817

Hi
My blood sugar is now at 102 , I missed a week of Rapamycin and watched on my diet, also took Curalin which works better than Metformin for me. I have started the Rapamycin again, 3 mg a week but this time I will check my blood sugar level every 2 days , if it rises again, I won’t be taking Rapamycin any more unfortunately .

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#818

I don’t know, it bothers me that most don’t have trouble with blood sugar and Rapa. You’re taking a pretty low dose of Rapa too.

It’s nice to have a number to go with your blood sugar, but you know that number bounces all over the place. I use the accu chek by aviva and if I’m worried I may do it several times a day. I also had a cgm for a while and it was expensive and really boring because I’m mostly keto and it really didn’t move much. Also I calibrated it with the accu chek and it was always off. So what I’m getting at is that there really is not a number to go with your blood sugar. Attia even says HbA1c is no good because of genetic variance. So I see no certainty anywhere here.

I know LPS causes type 2 diabetes. Vitamin D reduces LPS by increasing an antimicrobial peptide called LL-37 among other things. So make sure you have a vitamin D of about 60 and it could help the problem a lot.

I looked through the Curalin and it looks like good stuff, but mostly convinces and helps the pancreas to make more insulin. I prefer the approach of Jason Fung. His stuff is all good, take your pick on youtube.

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#819

The latest Statin Guidelines:

For adults ages 40 to 75, statins for preventing CVD or all-cause death make sense in those who have no history of CVD, but do have one or more risk factors and a 10-year CVD risk of 10% or greater—in this group, statins have at least a “moderate net benefit” and the recommendation itself is based on “moderate certainty” (Grade B).

For that same age group, with the same baseline risk and history but a lower 10-year risk (ranging from 7.5% to less than 10%), the same recommendation can be made, this time with moderate certainty and an expectation of “at least a small net benefit” (Grade C).

And related, recent news article:

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#820

HbA1C remains a very reliable marker for the prior 3 months of glucose with some exceptions as outlined here in the BMJ

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#821

“although not a perfect one. Common comorbidities encountered in patients with diabetes mellitus, such as renal insufficiency, high output states (iron deficiency anaemia, haemolytic anaemia, haemoglobinopathies and pregnancy)”

I think Peter’s problem was a haemoglobinopathy, he had small cells or something. My own personal lack of faith is from my brother whose numbers were sent to 2 different labs and the results were different by a lot. I forget the specifics now, but one lab said he was in trouble and the other said he was fine. I’m sure labs are certified and standardized, and I wouldn’t know how often mistakes are made, but it’s a really sensitive marker and maybe it’s hard to measure or something.

But yes, I watch mine and go by it. I wish it was lower. I’m glad it’s available. Thanks for the article

#822

Hi
Thank you for your feedback
I checked out Jason Fung but that won’t help me because I am 135lb and don’t want to lose any weight. I’m 5’4’’.
My glucose level, through diet has always been around 100, I had never had a reading above 112 but my glucose spiked to 134 a few days after taking 3 mg if Rapamycin. I know that this is still an experimental drug so I am now going to experiment by taking just 1 mg of Rapamycin once I get my blood sugar back under control. Then, if my BS level doesn’t spike , I will take 2 mg the following week and so on. I really want this to work as my Husband, who has no BS problems with it, will grow younger than me :grin:

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#823

Maybe consider sulforaphane from broccoli sprouts.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

https://www.science.org/doi/10.1126/scitranslmed.aah4477

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#824

WOW ! Thank you for that, we grow most of our own vegetables and have been growing a mix of sprouts on and off for about a year now, we will now grow broccoli sprouts after reading the great benefits. Thank you for that information :blush:

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#825

I never tire of reading that articke… lol.

It was what prompted me to go to my physician and start rapamycin 2 years ago. Life changing… literally.

#826

This is from a health article in the Daily Mail. Unfortunately, II can’t find the actual article that was referenced:

“Statins should be taken for LIFE: Heart benefits of cholesterol-busting pills are almost entirely lost if patients stop taking them in their 80s, finds study”

"Dr Runguo Wu, lead author from Queen Mary University of London, said: ‘Stopping treatment, unless advised by a doctor, does not appear to be a wise choice.’’

I did find this in my search and it suggests benefits that I didn’t know about

Beyond lipid lowering: the role of statins in vascular protection

“Although it is widely accepted that the majority of clinical benefit obtained with statins is a direct result of their lipid-lowering properties, these agents appear to display additional cholesterol-independent or pleiotropic effects on various aspects of cardiovascular disease, including improving endothelial function, decreasing vascular inflammation and enhancing plaque stability.”

#827

So a prior article suggested starting children on statins and this one says to stay on them into your 80’s. 90’s?
That’s a lot of statins for an absolute reduction of 0.8%. Statins for a lifetime should be Pfizer’s new motto.

For another very reasoned opinion

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#828

I am looking at statins in terms of healthspan. Healthspan not lifespan is my primary goal.
When I die I want to fall off the cliff and not spend any time in nursing homes etc.
I want my kids to say: “Oh no, dad died at the gym today while exercising”
Really my biggest fear is becoming a feeble person requiring nursing assistance etc. and becoming a burden to others.

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#829

The correct spelling /copy of the motto:

$tatin$ for a lifetime!

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