#2659

Not braindead, its just takes a bit longer, costs a bit more and gives better safety data. You’ve quoted a few studies where ACM is secondary endpoint.

#2660

Total fake news, as usual.

#2661

I agree. Its always stunning how many people get side effects in the placebo group

1 Like
#2662

Anuser, you’re sounding quite Trumpy now. Here’s one study you quoted only yesterday which used ACM as a secondary endpoint:

I don’t think the scientists behind this study were “braindead”. Do you really think they are?

#2663

You have a severe lack of reading comprehension or you are trolling.
That is why I keep asking you if you have even read what is said in this thread.

The problem is having the GOAL POST as ACM, that it is measured as a secondary endpoint is fine.
It is not fine to judge a study based on ACM.

And it is totally false to say that “it just takes a big longer, costs a bit more”, when the costs are at least an order of magnitude higher as >25 x larger study is needed.

Trolling or reading comprehension, what is it?

#2664

Also why are you engaging with me when we I said we should agree to disagree?
Tired of discussing with people who seemingly have an inability to read, or is trolling.

#2665

AnUser, :joy::joy::joy::joy:, are you in a bad mood today (again)? Sometimes you sound like a teen throwing tantrums. Is it the case?

3 Likes
#2667

Perhaps if your goal is to live a healthy life into your 70s. If you want to aim for 90s and +100s, or even give longevity escape velocity a chance, I think you want to consider things fundamentally differently - one need’s a paradigm change vs conventional, historical, med guidelines.

Btw, Peter separates what he does himself for what he does for his patients - and the “get down into 30-60 Apo B” is for people in general, not just people with his health history.

Btw2, here is an example of the view from a world leader, at a world leading (and often conservative) intuition:

*“The lower the LDL, the better,” says Professor Eugene Braunwald, MD, distinguished Hersey Professor of Medicine at Harvard Medical School, faculty dean for academic programs at Mass General Brigham and cardiovascular medicine specialist at Brigham and Women’s Hospital. “You can’t have too low an LDL."

(quote from recent feature in* MIT Technology Review)

3 Likes
#2669

AnUser may be right and I can’t read that well.
I have totally lost the point of this discussion.

IMO
Lower ApoB is better
Lower LDL is better.
Statins are good. (That does not mean all people can or should take statins)

People who argue otherwise are just not well-informed.
Also, IMO, most people who argue otherwise probably have higher than desirable lipid levels.

8 Likes
#2670

Yes, statins are good.

“Statins are a clear wonder drug”

1 Like
#2671

That’s what i said, ACM as a secondary endpoint.

Not sure why you think Im trolling. Maybe you’re projecting? Looking at your posts you seem to be pretty petty and abusive. Im just pointing out where I disagree. Maybe if you read the papers you’re arguing about before arguing I’d disagree less.

#2672

I am not easily offended, but some people are.
I don’t know your cultural background or gender. It’s common for individuals from diverse cultures to inadvertently offend one another. In this forum, it’s important to maintain respect for others’ opinions, even when we strongly disagree with them. Personal attacks are just not welcome.

8 Likes
#2674

@desertshores Yes. I spent 5 years looking for reasons that I didn’t have to take a statin despite highish LDL and >o calcium score. I didn’t want the “muscle issues” I’d heard about to interfere with my bike racing. And the internet was full of smart (sounding?) people saying that statins were bad and unnecessary.

I hoped it didn’t matter
I tried to avoid foods that would increase ldl in case it did matter. I stopped eating a high fat diet (eggs, low quality red meat, pizza, etc), and started eating more fiber (didn’t help)
I tried taking niacin to increase my HDL in case that did matter (that worked)
I hoped my ldl was discordant with my apoB (wasn’t)

I lost 5 years. And I finally decided I was being foolish with my one chance to slow down the progression.

Now my LDL and apoB are very low due to excellent medication that gives me almost zero side effects that impede what is important to my life. If side effects were bad, I’d still be experimenting with available medications to find a way to slow heart disease that killed my father.

13 Likes
#2675

Really? This is who you want to be? The resident troll?

I’m just trying to point out where some of your wilder statements (“braindead”, “convincing” “rogue doctors”) might not be quite right.

1 Like
#2676

Congratulations on getting it down. How low have you gone with ldl-c?

#2677

I’m done with this part of the discussion, good luck my dude. :+1:

#2678

“goal post” isn’t a scientific term. If you mean primary end point … Maybe say that?

#2679

That would super. Thank you. I’m sure you’ll find a chatboard somewhere with people who enjoy ad hominem attacks rather than discussing substantive issues.

2 Likes
#2680

What’s your medication? I’m struggling with consistently taking statins and that’s why I don’t have good results. I think that they give me muscle pain, though I’m not 100% sure that it’s a statin to blame. May be there’s something else. Decided to do one more attempt with rosuvastatin and ezetimibe before considering PCSK-9 inhibitor.

2 Likes
#2681

@LaraPo apologies if you’ve covered this already, buy did you try ezetimibe?