#2382

From the article: " Ezetimibe in combination with a low-dose statin, or as monotherapy in statin-intolerant patients, decreased LDL cholesterol, but did not significantly affect serum PUFA concentrations in patients with coronary artery disease."

I added ezetimibe to my daily dose of atorvastatin and have been taking it for several months.

I have not measured PUFAs in the past, but I have seen no detriment to any of my other blood markers.
I may add it to my list of yearly tests, but it isn’t a very high priority.

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#2383

Coincidentally I have some on the way also. We’ll see how it goes. Have high hopes for it.

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#2384

I will see also, doing 10 mg rosuvastatin and 10 mg ezetimibe every other day.
Trying to eat ‘healthy’ as well.

#2385

Ah… we’ll get you to the dark side eventually :wink: Soon it will be all broccoli and lentils for every meal.

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#2386
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#2387

Only six years? by my last count I’ve slowed my aging by 20, and I hope for much more hahaa

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#2388

What method did you use to count 20 year reduction?

#2389

The method of make believe :smile: but I do feel as healthy as ever, or as healthy as 15-20 years ago.
Another method I used is I approached a very attractive girl I thought she was in her late 20’s (actual age 33) and as we were talking, the age came up. Of course, I lied (big time) about my age. I said I’m 40 soon to be 41 and she didn’t question it. Needless to say we ended up together for a while but also needless to say it did not last that long (obviously, if you based your relationship on a lie it is bound to end pretty fast, I knew it though). so yes, I know I look younger than my age, but not by 20, more 5-7… however, I do feel as strong as I was 20 years ago, and my health is also the same.

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#2390

Ha-ha! It’s a great method! Keep working on it.

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#2392

Complements are important. They elevate our spirits. It’s also important imo to believe that you are young, strong, attractive, etc.

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#2393

Here in Hong Kong, everyone thinks I’m fat. When I travel back to the USA, everyone thinks I’m fit and healthy. Your frame of reference is indeed important.

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#2394

Regarding pantethine and policosanol for lipid-lowering, here is a summary from consumerlab, which does excellent and unbiased, fully-referenced reviews on many supplements:
(BTW that second column is titled “Evidence”, which for both is considered “inconsistent” by consumerlab)

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#2395

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That’s pretty funny.

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#2396

It is rather suspicious, isn’t it? I saw zero before vs after effect on my LDL when I tried policosanol years ago. Maybe the Cubans spiked theirs with w/rosuvastatin.

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#2397

What is epigenetic‑based drug discovery platforms (from the cited paper)?

#2398

Cyclodextrin is amazing:

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

https://sci-hub.se/10.1126/scitranslmed.aad6100

I did buy a box of RemChol. Very uncomfortable, I would say worse than DMSO or Niacin. Just not my cup of tea, but it will be interesting to see if it works, or if I go deaf.

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#2399

I think I’ll wait until Cyclarity releases their product…

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#2400

I’ll be right there too. In about 3 years if all goes well.

I think they gave the animals that went deaf 8gm/kg. So for me that would be 560 gm/day. I’ll be lucky to get 2 or 3 the way I’m doing it. I couldn’t find how to buy IV anywhere. There are a few places that would infuse it for me around here. Couldn’t buy. The polymerized form is much safer and I’m pretty sure that’s what they use.

That’s ok, my plaque was going down very slowly anyway. I just want it gone.

#2401

Summary:

  1. Low LDL does not affect your brain.
  2. Dietary sources of cholesterol do not increase blood cholesterol.
  3. Take Rosuvastatin and Ezetimibe to lower LDL

Rehashing the basics mostly.

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#2402

All statins cross the BBB according to Thomas Dayspring, I don’t remember if I saw evidence for this but I believe it as well now.

Decreasing cholesterol synthesis in the brain from statins passing the BBB can decrease desmosterol levels, of which lower levels is associated with Alzheimer’s disease.

Hence many of us think other drugs are more optimal especially if someone has an ApoE4 allele and can’t check their desmosterol levels. But of course there is other evidence as what Brad puts up.

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