#2362

What I meant by effect is clinically meaningful effect. I do not mind 1 molecule of bempedoyl-CoA inhibiting 1 molecule of acetyl-CoA production in the prostate because of some extremely low amount of expression of SLC27A5 as it’s indistinguishable from normal variation, I do not think it has any effect at all and the risk of BPH is from something else probably has to do with downstream effects of altering cholesterol levels. It is also lower than 700 times as most will be used in the liver.

I will soon look into the acetyl-CoA hypothesis to determine if that is a problem in the liver where the drug will have an effect. A bit that I looked at, I do not think it is a problem, but that might change.

#2363

There is a clinically meaningful effect in terms of aberrant splicing. This does not happen for everyone. We cannot be certain exactly what the cause is. I think the acetyl-CoA cause is most likely, but then I eat a lot of citrate so I know what the effect is on me (and others who do this as well mainly friends and family).

#2364

If there is extremely low amount of bempedoyl-CoA it cannot have a clinically meaningful effect as that is physically impossible. The body is a physical system no matter the genetic variation. It is the same as homeophatic dillution when you dilute something so much there is almost nothing left or nothing at all. If you decrease something by 700 times and even more there is not much left to do anything. As shown a decrease by 85% showed almost complete nullification.

#2365

We should agree to disagree. I am quite happy for you to have the last word if you prefer.

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#2366

I don’t know how you can disagree with that, but sure.
I will look into acetyl-CoA soon and how it will affect the liver.

#2367

@scta123 would you have any suggestions re optimal ways to leverage fiber / types / amounts / timing for Apo B lowering?

(I am an over/high absorber, thought I generally had reasonable amounts of fiber in my diet, but would like to try good ways to further optimize it)

Anyone have measurable impact via a diet/fover strategy?

#2368

I am adding 10 mg rosuvastatin every other day with the 10 mg ezetimibe daily, mostly because bempedoic acid isn’t probably going to available for a long time in EU, and it is most practicable for me to take it every other day, I don’t have 5 mg tablets. Once PCSK9 inhibitors are generic or bempedoic acid is more available and I have researched the Acetyl-CoA hypothesis more and if I found no problem with it in the liver I will switch it up for the latter, or the former.

No way that Ezetimibe is going to work enough for me.

edit: doing 10 mg ezetimibe and 10 mg rosuvastation every other day to simplify it, 5 mg ezetimibe per day is pretty good anyway.

#2369

@AnUser Order bempedoic acid from India.

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#2370

This is anecdotal, but few months ago my friend and I decided to get our ASCVD assessment done, he was medium/high risk and his LDL-C was really high… we got a dietary recommendations among other lifestyle proposals to reduce the risk. In about three months his LDL-C dropped from 170 mg/dl to around 115 mg/dl. His two interventions were adding 20.000 steps daily and eating around 70 g of fiber daily, of which at least 5 grams of soluble fiber with every meal.

My personal experience with fiber is a more miserable one. I tried to add two tablespoons of psyllium to my diet, but my intestine was terribly uncomfortable and I quit after two weeks. But my LDL-C was not high to begin with otherwise I would have stuck with it. My friend said that it took him more than a month to adjust to that amount of fiber and to not go into details, he said that at one point he was contemplating of getting adult diapers.

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#2371

For fiber I use organic flaxseed, I grind them, put them in yogurt, let it sit for 1/2-1 hour then consume. Alternatively use them ground on salads, soups as a substitute for flour or even make steak sauce with it. Virtually all carbs on flaxseeds is actually fiber. I hated psyllium husk fiber. Organic Oat bran boiled in milk and let it cool is another great choice(pretty high fiber and tasty)

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#2372

I eat about 25g of chia seeds every day. Mixed with a smoothie and normally 5g of mixed citrate.

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#2373

I used to eat flaxseed “pudding” often, freshly ground flaxseeds, cocoa, some honey and milk. Tasted great. Sometimes I would add some ground hazelnuts too. Really tasty. But then I read somewhere that flaxseeds is not recommended for men due to increased risk of prostate cancer or something… maybe I will revisit my decision.

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#2374

Isn’t that terribly laxative? What kind of citrates do you mix?

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#2375

The usual ones, Sodium, Potassium, Magnesium and Calcium. Remember this is all about increasing nuclear acetyl-CoA levels.

I vary my citrate intake between 5g a day and 40g a day.

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#2376

I think it is the opposite, flaxseeds prevent or lower risk of all cancer, especially colon cancer. The only negative supposedly is that it may affect estrogen, but I think you have to consume way more than couple spoons daily for that.
Forgot earlier that chia seeds in moderation are good source of carbs also. I wouldn’t do more than 1-2 teaspoons of chia daily. Used them in the past but gave me GI issues, and to my surprise were not anti-inflammatory for me, but still good in small amounts (especially for bowel movement).
As far as ground flax, I found them to be most anti-inflammatory of all other foods, akin to wild salmon, and actually even better. no other fruits or foods came even close to flax seeds in fighting inflammation for me. Obviously, what may work for one, it may not work for everyone.

For me, it is literally the ONLY food that deserve the “SUPERFOOD” label.

Flaxseed | Memorial Sloan Kettering Cancer Center (mskcc.org)

Flaxseed is used to:

  • Prevent breast, prostate, and colon cancer
  • Control blood sugar level in patients with type-2 diabetes
  • Lower high cholesterol
  • Manage symptoms of menopause (permanent end of menstrual cycles) such as hot flashes and night sweats
  • Treat constipation (difficult or infrequent bowel movements)

Flaxseed also has other uses that haven’t been studied by doctors to see if they work.

It’s generally safe to use flaxseed in food and drinks but talk with your healthcare providers before taking flaxseed supplements. Herbal supplements are stronger than the herbs you would use in cooking.

Side effects of using flaxseed can include:

  • Allergic reactions
  • Increased bowel movements (poop)
  • Having gas
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#2377

Oat bran is delicious even if cooked in water, then add some EVOO and salad greens. I like it a little spicy.

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#2378

It’s not likely to work, need 365 tablets a year, that is a lot that needs to go through EU customs.
Meanwhile Everolimus is dosed at 5 mg / week, and it is sold in 5 mg tablets. Only need 52 tablets for a year, that seems possible.

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#2379

Still another off-beat method (maybe) of reducing cholesterol with a pill.
I found this while looking for ways to boost testosterone without doing TRT.
“Enclomiphene therapy results in more significant and sustained increases in TT and E, as well as more significant and sustained decreases in TChol, HDL-Chol and LDL-Chol, than T gel therapy. Clinically insignificant effects on PSA, Hgb, and Hct are observed. En may represent an effective, low-risk treatment option for androgen deficient men with few adverse effects.”

I could certainly use some more T. My latest blood test shows that I am very low.
So, maybe a double benefit from taking enclomiphene?

I have some on the way and I am going to give it a try.

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#2380

Let us know how it turns out! :slight_smile:

#2381

On the other hand, this study showed no effect of ezetimibe on serum PUFAs:

Notably, they didn’t measure ALA levels in this study, but as long as EPA/DHA are unaffected, does it really matter? I also wonder why ALA absorption would selectively be decreased by ezetimibe, while absorption of other PUFAs, fat soluble drugs and nutrients would appear to be completely unaffected. It doesn’t seem to add up.

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