#64

So much stuff to digest! In my quest I pretty much ignored apoptosis, and focused specifically on anti-angiogenic activity. My quest was to make sure any tiny cell clusters floating around find it difficult/impossible to attach to the circulatory system.

So much unknown stuff especially the use of antioxidants such as Melatonin during Rad Therapy. Tons of data show Melatonin protects against radiation, but what if it’s the radioactive damage (an oxidative process) is what you’re after? I wish I could find a good book on that.

I will use Melatonin cream on my skin during IMRT. Ain’t no PCa in the skin of my abdomen… and there is good evidence that it’s helpful (though the article was aimed at skin over breast cancer)

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#65

The thing that helped you most (if I had to guess) is you losing weight and getting rid of sugar/donuts.
A lot of people have a Gleason 6 and live well into their 80’s and 90’s (without ever knowing they had it). I’m tempted to think that anything you did (including Vit D) have little or no impact (other than healthy lifestyle).
As for melatonin I am in the camp that believes it does more harm than good, especially at high doses. I had negative experience on anything over 1mg, but of course we are all different.

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#66

yes, when it comes to targetting PC, there are a lot of potential interventions, like IP6+ myoinositol.

Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic - The Journal of Nutrition

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#67

Thank you, and thanks to all for input. So much to read, so many substances that do inhibit cancer, one way or another. Perhaps it’s my 5-6mg of Sirolimus that I take weekly that’s inhibited distant mets.

The sad thing is that no entity (or perhaps just a few) pay much attention, because there is no patentable opportunities, and therefore no profit. It’s quite the opposite that today, unlike not too many years ago, one can obtain high-quality pure (or mostly pure) substances for really, a very little amount of money.

I suspect that as AI becomes mainstream, that these substances might move more to the forefront, not to destroy cancer so much, but often as adjuncts to chemotherapy.

#68

I doubt weight had much to do with it - I’m only about 10 lbs different. Vit D has made a huge difference in my immune system. Just before I was diagnosed i also had pneumonia.
since increase Vit D levels above 50 - not had a cold or Covid and no vaxes
I think immune system health is a key to cancer

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#69

Paul, at some point did you mention that you were on a keto or ketosis-like diet? I ask because I continue to wonder about the ability of cancer cells to survive on ketones versus glucose. Thanks.

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#70

That’s part of Thomas Seyfried’s suggestions.

#71

How much Vitamin D do you take?

#72

Isn’t it that even if you are in a keto diet your blood will still maintain a certain level of glucose? and then if cancers cells (and most cells) in the body get their food from the blood doesn’t that mean they will always have a supply of glucose to feed on regardless of your diet? Real question btw.

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#73

RapMet, I don’t know for sure and will avoid making an assumption. Ask one of the doctors on this site for a precise answer.

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#74

Lol, I’m not a doctor, but I do know that a blood glucose level of zero, is not the blood coursing through a living organism. Also, cancer cells don’t need glucose to thrive. In the absence of glucose, a cancer cell will happily use uridine, as happens when pancreatic cancer cells don’t have access to glucose. Furthermore, if there is no exogenous glucose available, cancer cells will latch onto glucose generation through gluconeogenesis (substrate: lactate, amino acids).

Unfortunately, cancer cells are very hard to kill, without also killing healthy cells, i.e. killing you, as you can’t live with all your cells dead. That’s why chemo is so rough on patients. The metabolic approach to cancer is a dead end, or more accurately, in some cancers, under certain conditions, you can successfully use a metabolic approach, such as glucose deprivation, but that’s certainly not all cancers. And the job doesn’t end, because if there is some persistent reason why the cancer arose in the first place (like perhaps a tissue environment permanently perturbed by a powerful carcinogen - example, UV burns, or radiation particle exposure rendering the whole tissue - like the skin - a soup of deranged DNA). So you killed that one cancer, and immediately the damaged tissue throws up another, so now what, you’ll try the glucose deprivation all over again in perpetuity? Note, how the most successful way, to date, of complete cancer cure is through getting the immune system to recognize cells as cancerous and killing them. That’s the immune system sending out a bunch of soldiers and killing the cancer cells one by one, and then standing guard to kill the next one as soon as it’s created, and you don’t have to do a thing, same as if vaccinated, or through natural immunity you are always suppressing germ attacks any time one appears. Immune system cells, killing one by one, and then standing guard, not some global process of mass starvation of all cancer cells at once by removing glucose or some other temporary metabolic approach that has cancer roaring back as soon as it stops. Sorry.

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#75

I read through most of the messages and replies. I’m not clear on whether it has been established whether you have distant metastasis or not. I had prostate cancer 7 years ago that had spread into the seminal vesicles and had perineurial invasion (but no known distant mets). I had a robotic prostatectomy, 3 months of radiation and 2 years of hormone treatment (Lupron and Casodex).

I have very mild urinary incontinence (I wear 1 thin pad daily). I do have erectile dysfunction. My life is otherwise good and my PSA is zero. I found the hormones tolerable and enjoyed the fact that I had no body odor for a couple of years,

I used the “TruMe” epigenetic test bought from ProHealth Longevity for under $100. In July of 2022 I was 68 and my biological age was 69. In September of 2024 at age 70 my biological age was 62 yrs 2 months. I had been on rapamycin for a few weeks and was still titrating up. I have been taking Novos Core, NR/NMN, and lots of other supplements during the intervening time.

I’m not sure that I trust any epigenetic or telomere based age test, but I do feel and look younger than my chronological age. I’m just sharing my experience, not implying what anyone else should do.

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#76

Thanks @CronosTempi , great info. I must add that I always had my doubts. I also find it insulting (to some degree) when you have professional doctors (mainly in social media) making outlandish claims such as cancer cells can’t survive without glucose. Well, wouldn’t it be the easiest thing then to kill cancer by simply not eating any carbs? LOL

It would be acceptable to identify certain factors/foods that might help or aggravate the situation, but I think that their medical license should be revoked for doctors that make such ridiculous claims which are very misleading and also steer people in the wrong direction.

I also find some invitro studies useless (for most part) and misleading. As an example, there was this invitro study that capsaicin, or this substance and that substance that killed cancer cells. Well, I can think of 1000 things and methods that I could kill cancer cells invitro. How about burning them at 5000 degrees, but how will that be applied to a live human being LOL.

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#77

It depends on how much sun I get - summer 0-3000 mg
winter 3000-5000
I measure blood levels of D twice a year to ensure I’m above 50 and below 100

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#78

I did for a couple of years. Right now I am not quite keto but below 50 gms of carbs a day

#79

If it doesn’t have an effect in the ITP it is worthless for cancer.

#80

Like you, metatstatic, but not distant. From what I understand, mets to the pelvic lymph nodes or even to pelvis (bone) are considered “curable,”. MY PSMA-pet scan shows that the cancer has spread to the “pelvic sling,” (~4-8mm deep, just adjacent to the prostate) but not to the seminal vesicles. I do have perineural invasion so my R neuro-vascular bundle is “toast” (using the proper medical terminology.

It seems odd that you’d have had a prostatectomy + IMRT. Was that from the get-go or was that due to a biochemical failure after the prostatectomy (meaning a rise in PSA).

If it stays that way, my prognosis is good. I’ll do Orgovyx + Abiraterone + IMRT (rad) then, hopefully the two ART meds will shrink my prostate somewhat and I’ll go to Boston and have Brachytherapy (high-dose tiny implants to the prostate).

Likely the only way I’ll ever have an erection is with injectables or a penile implant.

I consider myself lucky because there are no distant (beyond the pelvis) mets.

Interestingly in a month or two, when Social Security tells me exactly who I worked for in 1970 (spraying 2-4-5-x aka Agent Orange) I will apply for MA Workers’ Comp. I can’t remember the firm I worked for, but it was above board, I held a MA pesticide applicator license, and there is no question that I was covered by Workers’ Comp.

Interesting because it’ll be denied (actually it already has) but I’m an Occupational Health RN who works contracted to US DOL and Workers’ Comp NH/VT/MA/RI is my specialty.

Any military that was exposed to Agent Orange who develops prostate cancer is presumed to have a workplace illness. We’re talking about tens of thousands in the military…all presumed to have a workplace illness.

It’ll likely end up in Court, but I’m down for that…

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#81

Research out of China, but what the hell:

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#83

Scientists Have Discovered a Simple Supplement That Causes Prostate Cancer Cells To Self-Destruct

Menadione, a vitamin K precursor, shows promise in slowing prostate cancer in mice by disrupting cancer cell survival processes, with potential applications for human treatment and myotubular myopathy therapy.

CSHL Professor Lloyd Trotman’s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression in mice. The supplement is a precursor to vitamin K, commonly found in leafy greens. The story begins more than two decades ago.

https://scitechdaily.com/scientists-have-discovered-a-simple-supplement-that-causes-prostate-cancer-cells-to-self-destruct/

##Journal Reference:

“Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function” by Manojit M. Swamynathan, et al, 25 October 2024, Science .
DOI: 10.1126/science.adk9167

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#84

Research from the 1980s and 1990s has demonstrated that vitamin K3 is harmful to humans.

These studies have linked vitamin K3 to liver damage and the destruction of oxygen-carrying red blood cells

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