jakexb
#1
寻找下一个雷帕霉素类长寿药物的重要努力：
Ora Biomedical 开发了革命性的新技术，将机器人技术与人工智能相结合，自动分析线虫的寿命和健康状况。这项技术使我们能够定量评估长寿干预措施的影响，其规模比目前的规模大三个数量级。我们的目标：在 5 年内评估 1,000,000 项长寿干预措施。这就是百万分子挑战。
通过赞助这里的干预措施，您将直接为长寿科学的发现做出贡献。您共同拥有数据，甚至可以选择干预措施。单一干预、干预组合（我们喜欢组合！），甚至整个目标库。全取决于你。与朋友和同事竞争，看看你在长寿排行榜上的排名如何。虽然您随时可以选择退出，但我们希望您考虑允许将您赞助的干预措施存入一个公开的长寿数据库，该数据库将不受限制地向全世界开放，从而促进长寿科学走向未来。
这是如何运作的？
这很简单。 Ora Biomedical 创建了一系列干预措施，您可以选择赞助。只需从下拉菜单中选择您希望赞助的干预措施，或者您可以选择让命运决定并使用我们的随机干预机器为您选择干预措施。赞助干预的费用为 100 美元。
来源： Ora Biomedical Twitter 帖子
了解有关众筹赞助机会的更多信息：
https://orabiomedical.com/sponsor-mmc/
倡议视频： https://www.youtube.com/watch?v =kEzRU_jTKl8
13 Likes
Ooooh. We should pool our money and sponsor a test. What shall we test?
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More details on this program, who is going to fund some interventions? I know of at least one person…
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Bicep
#4
Wow, I can’t believe they had Pentadecanoic Acid Supplement on the list.
They must have tried everything on the list already. Not that many things on there.
Neo
#5
Went through the process for (dimethyl fumarate) - very simple and quick.
2 Likes
Interestingly they have Citric Acid on the list, but none of Magnesium, Sodium, Potassium or Calcium citrate. My view about Citric Acid is that the acid aspect is harmful in the volume of citrate that you need to take to have a good effect. They also don’t have melatonin on the list.
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@Bicep and @John_Hemming I have talked to the people on the Ora Biomedical and their current library consist of 2350 FDA approved drugs and some small number of natural compounds. They will expand they library with more drugs and natural compounds. But every such step is an investment.
One investment we are doing in the “Rapamycin Longevity Lab” initiative is to add 200 mTOR inhibitors to the library. You can read more about this initiative here.
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I buy citrate in bulk (25kg) (some hydrous some anhydrous) and it costs about GBP 15 per kilo. Obviously smaller quantities would be more expensive per kilo.
In the end, however, I have my own small biohacking trial that is gradually increasing in size so I am not particularly bothered what effect it has on worms. I would pay them a reasonable amount for a test, however.
Citrate is solidly GRAS. When people have a blood transfusion for example, it tends to be infused with sodium citrate which is also used to make Nachos. (the formula is Na₃C₆H₅O₇) Given my experience with eating insane quantities of citrate I wonder sometimes if one of the benefits people get from a blood transfusion arises from the additional gene expression from the citrate.
I see no merit, however, in me giving them funds to test anything else just because the test is cheaper.
They do have C₆H₈O₇ on their list (Citric acid, Citrate plus three separate protons) the main acid in Lemon Juice (and Lime Juice/Grapefruit Juice).
However, I think eating a lot of acid would be something I would not wish to try. Cells deacetylate the histone to increase the pH which would be a really bad thing.
1 Like
What biohacking trial is it that you refer to? Is it the MN=1 that we talked about?
I don’t see any conflicts with that human trial and large screening in worms. As I see it the screening will open up totally new territories in the longevity field that we have not looked at yet. If we would for example get a really large combination effect of one FDA approved drug and Rapamycin then that combination would be very interesting to do a ITP on and see if the effects also exist there. This way we come step by step closer to human trials and move the field forward.
Curious question, do you see very little value in doing large scale experiments in a cost-effective way where Rapamycin is combined with FDA approved drugs and natural compounds? What would be needed to increase the perceived value for you?
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No its not the MN=1 trials that we will be doing via rapamycin news. It could be one of those trials, but as it is my own personal hypothesis I think it best that we start with something else.
I have a small group of people - mainly friends and family - that are following the protocol to improve gene transcription (and translation). I don’t mind if more people join that, but what I have suggested as the first MN=1 trial relates to Rapamycin.
The reason why I personally am not particularly interested in testing lots and lots of molecules is I have a clear mechanistic hypothesis (transcription/translation) where it is clear what you can do that is synergistic and it produces good results. Hence I personally want to focus on this. Rapamycin is part of this because of its effects in mitochondria.
Because we are doing that testing in human beings, therefore, there is a lesser, but non zero merit in having some worm testing.
In the absence of a realistic practical hypothesis the approach of testing very large numbers of molecules has merit and I am not saying to anyone they should not do that. However, my situation is different.
Because I don’t need any funding (I am self funded) and I already have people in my biohacking trial I am not really beating the drum for my protocol. What I need to do is to get on with the testing. It is quite complicated because it is multidimensional and has two main pathways. Hence in transcription there are issues about levels of acetyl-CoA, RNA, HDAC inhibitors and also I think serum Lithium. In translation it is all about mitochondrial efficiency, but a lot affects that. Hence I am testing out lots of different approaches in terms of dosing, timing and combinations.
In the mean time I have to get on with life as well. I am a tech entrpreneur and investor as well as a musician and I have five children - only one now under the age of 18. Hence I am quite busy.
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jakexb
#12
Just sponsored one. Hope they get tons of people funding this!
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I find it rather amusing that this week Matt and Brad Stanfield chose colchicine as the medicine to test in the wormbot.
Given our recent conversation about this drug:
Of course, more broadly it looks like an interesting drug: Gout Medication Colchicine Reduce Myocardial Infarction? 2019 N Engl Journal
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I think Rapamycin + Taurine is going to be a winning combination. Let’s see if I’m right.
Seems they’ve raised about $860,000 through this challenge in 2 weeks. Honestly, this is the way to raise money for longevity research.
I’ve supported the Million Molecule Challenge! https://orabiomedical.com/product/double-compound-intervention/… #millionmoleculechallenge via
@OraBiomedical
How do we find the leader board?
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Based on how toxic colchicine can be, I think that wasn’t the best choice by Dr. Brad. But, why not give it a go anyways…
jjrap1
#16
I supported them too. Not a biologist so I let them choose; would be interested in seeing what I (and others) have ended up selecting.
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jakexb
#17
Longevity is a perfect match for this strategy. We know that the basic pathways are conserved across evolution all the way back to really simple organisms. And it’s pretty easy to tell whether a worm is living or dead. So you have an automate-able endpoint and a simple model organism with a short natural lifespan and you can just go to town. Really genius stuff.
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Curious
#18
Did you bet on Rapamycin + Taurine? just to make sure I understand the competition 
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I did. I paid $200 to do the combination of the two chemicals.
Frankly, I also want to know the answer personally as I am taking both compounds daily. It’s about as expensive as a blood test, and in some ways more informative. Rapamycin and Taurine are the two supplements I take the most of. I want to know if they work well together.
I recommend others do the same if you are taking a few supplements together.
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jjrap1
#20
One question I had: what happens when multiple people choose the same protocol? For instance, I can’t believe that the rapa/taurine combo hasn’t been submitted multiple times already??? What then? How/where can one find out what protocols have been selected to be tested?
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