My DAV* Therapy Experiment begins! *Doxycycline, Azithromycin and Vitamin C

[scta123]

@AnUser

I don’t think you understand the hierarchy of evidence

I do understand it quite well, but I do also understand biases behind it and also why for some mechanistically sound concepts there is almost impossible to find funds to do further study evaluations.

[KFISH]

I am doing it to kill senescent cells only- nothing else. But this form with all the scary post is making me rethink my decision to continue although I consider myself healthy! But I can find 20 papers on Rapa that have scary side effects too!

[KFISH]

Thanks Joseph let’s do this! I finish Nov 1!

I appreciate all the concern about the side effects but seriously on this form? IMO most all taking Rapa are taking a risk, you really never know what lurking in our bodies and DNA.

[AnUser]

So why are you comparing a mechanistic study with clinical trials then? As if no one has more information about a drugs efficacy based on a clinical trial compared to mechanistic studies?

@KFISH

But I can find 20 papers on Rapa that have scary side effects too!

Rapamycin doesn’t have a post-market warnings from the FDA as I showed in a thread about this.

[KFISH]

Thank you for your concern! Peace!

[essexaid]

I appreciate being made aware of any apparent potential dangers of taking Azithromycin. However we need to keep things in context. The DAV therapy that people are trying here uses a total of 10 Azithromycin 250mg doses over a period of five weeks. That is nowhere close to the standard antibiotics regimen where any potential for elevated risk has been observed. In fact the trial cited that was aborted had been using “long term” Azithromycin therapy. It would appear yet again that it is probably the dose that makes the poison.

[desertshores]

“in patients with preexisting CVD (risk ratio [RR], 1.48 [95% CI, 1.06–2.06]).”

[AnUser]

@scta123

I still don’t know how your findings would be decisive in wanting to try low dose combination therapy that includes azithromycin in subclinical dose?

The dose with increase in cancer relapse and death was 250 mg azithromycin 3 times weekly. The translated article protocol does 250 mg two times a week. Not sure why you call that subclinical dose, if it’s only 34% lower than the dose showed to increase cancer relapse and death from long term use in a clinical trial.

@essexaid

That is nowhere close to the standard antibiotics regimen where any potential for elevated risk has been observed. In fact the trial cited that was aborted had been using “long term” Azithromycin therapy. It would appear yet again that it is probably the dose that makes the poison.

It calls into question the ‘efficacy’ of this therapy if a 50% higher dose for one of the drugs increases cancer relapse and death in a clinical trial. Nothing extraordinary as it’s typical for mechanistic studies to fail or even be harmful as a therapy is studied further.

@desertshores

“in patients with preexisting CVD (risk ratio [RR], 1.48 [95% CI, 1.06–2.06]).”

Yes, there might be people with CVD here so for them it’s good to know and not an automatic ‘no brainer’ as it apparently is for some.

[blsm]

I finish November 17 exactly 1 week after my birthday.

[JuanDaw]

See my post above. The patients took doxycycline for thirteen months.

243 patients were to receive > > azithromycin (250 mg) 3 times weekly for 2 years; 237 patients were to receive placebo for two > years, starting at the time of conditioning regimen. The immunomodulating effects of > azithromycin therapy were evaluated when used for the long term prevention of BOS.

Results: The ALLOZITHRO study treatments (azithromycin/placebo) were terminated on the
> 26th December 2016 i.e. at thirteen months after completing recruitment

[Danlalane]

Hmm. I was using some hyperbole in my statement. Hard to read tone in a blog post. btw - if you have read any of the science on human relationships and friendship you will see pretty conclusive evidence that giving advice (i.e. being officious) is always detrimental. It is related to horizontal and vertical relationships, humans work best with horizontal relationships - aka we are all the same, no one is better than anyone else.

I did read the research on doxy quite extensively because I had been taking it weekly with my rapa dose to prevent rogue bacteria from inhabiting my Birmingham hip device. Vitamin C is benign and most of it is pee’d out. Azithromycin is the wildcard and I have taken it before without issues. In fact as I have stated before I ‘feel’ better, have healthier hair and experience some of the claims in the research study used to kick off this thread. So risk reward to try this for 5 weeks where the Z is only every 3 days seems quite low to me. Also, I have joint issues, arthritis and there is some evidence that bacteria cause it. I didn’t explain myself for you @AnUser, but for others thinking about trying it.

[约瑟夫]

As I have stated before, the only change I feel is less knee joint pain.

My modified DAV Therapy

Taking :

250mg of azithromycin once ever 72 hours

100mg of doxycycline every 8 hours {I did miss o few times the 8hour window, just moved the dosing forward]

2.4g{yes grams ] of Vitamin C, two types approximately 4 hours after taking either the azithromycin or the doxycycline

Have not had any side effects, been on this dosing since September 25, 2023 will be on this till October 31,2023 a total of 36 days.

Not taking rapamycin during my DAV Therapy dosing.

[AnUser]

@Danlalane

experience some of the claims in the research study used to kick off this thread

It’s not a research study, it is a translated article with one anecdote.
What would be common in health magazines, for example.

It’s probably snake oil.

[约瑟夫]

And it is being tried by several member of this forum.

Your opinion is not relevant.

[AnUser]

That’s not science or scientific evidence. That’s psuedoscience or anecdotal evidence.

[约瑟夫]

@AnUser

…“That’s not science or scientific evidence”…

Published paper from the University of Salford by head of department with a MD PhD,{in bio-chemistry] is not science!

"AnUser"you have issues.

I do not care if you do not like my comment.

[AnUser]

I was referring to the claim that ‘it is being tried by several members of this forum’, and not the published mechanistic study. That is anecdotal evidence. The translated article is not a research study.

[blsm]

@Joseph

Not taking rapamycin during my DAV Therapy dosing.

I was just going to ask about this. If you don’t mind would you be willing to share your thoughts on skipping rapa during DAV?

[jjrap1]

Hello All,
I’m really interested in trying this protocol as well, and have been trying to keep up with the members who are currently doing it, and whether they are following the ‘standard protocol’, whether they paused rapa use, their end date, and any other salient/important details. And later, of course, their perceived subjective as well as any objective test results.

Std protocol:
“For 5 weeks, azithromycin was administered at 250 mg twice weekly, doxycycline at 100 mg twice daily, and vitamin C at 500 mg once daily”

Here are the folks I know about from following this thread; are there others who would like to make themselves known?

KFISH: std protocol - rapa/all supplements paused - ended 11/1/23. Finished “DAV” ‘reported no side effects, blood test came out perfect same as usual there was no changes to any longevity blood markers.’
约瑟夫 : modified protocol - doxy 3X/day, azithro every 72hrs, ~2g Vit C 3x/day (4 hrs after taking doxy or azithro) - not on rapa at time - ended 10/31/23
blsm: modified protocol - 50mg doxy, std azithro, 140mg Vit C (vacsorbyl palmitate); later increased acsorbyl palmitate to 500mg - post doxycycline - end 11/17/23
Danlalane: std protocol - continue rapa - ended after day 9 (" I feel my GI and gut microbiome are taking a hit.“)
Rmun: modified protocol - 50mg doxy 2x/day, 1g Vit C/day - end ??
Walter_Brown: started 10/24 " I have multiple sclerosis (which is in long term remission due to Mavenclad), I have suffered from continuous neuropathic pain and stiffness in my legs. I am not sure which part of this DAV therapy is being effective (anti-inflammatory or autophagy or both), but the stiffness is gone and my pain is (and continues) decreasing.” (reported 10/30) improving skin? (reported 11/3)
DrT - pending more info about effects for those with AF
Vjha: std protocol - ended 11/1/'23
Lowroad: will begin soon
desertshores: Started 10/22
Mogli: started/stopped after a week (“i stopped DAV after one week because DOXY was giving uncomfortable upper stomach pain, but also wanted to add I felt bloated a bit, and seemed like I wasn’t digesting food as good as before”)
Goran: ended ??? a couple days early; pills ran out. No side effects from DAV whatsoever. “Two thumbs up from me”.
essexaid: standard protocol, but 700mg vitamin C powder.
J0hn: 50mg Doxycycline (Dr Reddy’s Doxycycline Hyclate and Lactic Acid Bacillus Capsules) twice a day, 500mg Ascorbyl Palmitate, 250mgs of Azithromycin twice a week.
SNK: standard protocol, stopped after 1 week due to stomach issues.
jjrap1: will start 1/'24

[Danlalane]

Std, not stopping Rapa. Started 10/12, ending 11/16.