In regard to it being a senolytic, I need to do more research. I can only speak on the cancer side of things.
- Side note: I also don’t like how many studies use Vitamin C interchangeably with ascorbic acid (honestly I do it myself for simplicity). Ascorbic Acid is what most “Vit C” supplements and IV’s contain, and they work differently than actual Vitamin C from Camu camu, acerola cherry etc…
Here’s a thread about that: WHAT’S IN YOUR VITAMIN C ? - Liebowitz Longevity Medicine
For example, I take this Vitamin C supplement because it is actual vit c and doesn’t irritate the gut. (Pure Radiance C® Capsules | Natural Vitamin C | Pure Synergy®)
- In the same study you quoted in Oncotarget it says the following which is my point.
" It is worth noting that Vitamin C plasma levels vary considerably with the route of administration. For instance, pharmacokinetic studies performed by different research groups have assessed that, after oral administration, Vitamin C plasma levels reach concentrations of ~70-220 μM [reviewed in reference [30], which represents the maximum tolerated oral dose. By contrast, Padayatty and co-workers found that, compared to oral intake, intravenous administration results in 30- to 70- fold higher plasma concentrations of Vitamin C [31]. Furthermore, consumption of 5 to 9 servings of fruits and vegetables per day allows plasma levels of Vitamin C to reach up to 80 μM at steady-state, with peak values of 220 μM [31]. Remarkably, an **intravenous infusion of Vitamin C can reach plasma levels of 15,000 μM (i.e., 15 mM). Interestingly, doses of up to 50 grams per day, infused slowly, didn’t exhibit any toxic side effects on cancer patients [30]. These observations suggest that intravenous administration of Vitamin C may have a role in cancer treatment, as this route allows higher plasma concentrations than those achievable with the maximum tolerated oral dose."
- To ensure you are getting a pro-oxidant effect IV is always reccomended as we need to be certain we are eradicating CSC and not protecting them. How do you know what your serum peak level when taking oral ascorbic acid and that you reached the max blood concentration? You don’t. But you can bet you reached 30 - 70 times what you could have gotten orally, in an IV.
Plus, there is a line of thought in cancer, that antioxidants support the tumor microenviroment by preventing apoptosis through scavenging free radicals. Let’s say someone was going to do a pro-oxidative treatment (high dose IVC or ozone) or is on some sort of cancer drug (anthracyclins, platinum based drugs etc…), and they decide to supplement with oral ascorbic acid. You are basically negating the effects of the treatment while giving protection to the CSC.
To reach oxidative potential and to ensure that it has reached the CSC and caused maximal death to CSC the dose would need to be high enough. I just have too many concerns with oral ascorbic acid, as it is not even close to effective and potent as IVC.
Anyways, I might’ve not answered your question completely, but in dealing with cancer, cancer cells adapt to whatever you throw at them. The patients usually do not have much time left, so we have to filter and find the most effective options with the least side effects and most comfort otherwise it is just a waste of time. Patients prefer a IV over oral supplementation which inevitably will cause bad diahrrea and stomach upset. Ultimately the decision comes down to multiple factors. One of which is because Vit C serum testing isn’t accurate, economical or practical, we need to be certain we are hitting the CSC.
