#160

And it is being tried by several member of this forum.

Your opinion is not relevant.

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#161

That’s not science or scientific evidence. That’s psuedoscience or anecdotal evidence.

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#162

Published paper from the University of Salford by head of department with a MD PhD,{in bio-chemistry] is not science!

"AnUser"you have issues.

I do not care if you do not like my comment.

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#163

I was referring to the claim that ‘it is being tried by several members of this forum’, and not the published mechanistic study. That is anecdotal evidence. The translated article is not a research study.

#164

I was just going to ask about this. If you don’t mind would you be willing to share your thoughts on skipping rapa during DAV?

#165

Hello All,
I’m really interested in trying this protocol as well, and have been trying to keep up with the members who are currently doing it, and whether they are following the ‘standard protocol’, whether they paused rapa use, their end date, and any other salient/important details. And later, of course, their perceived subjective as well as any objective test results.

Std protocol:
“For 5 weeks, azithromycin was administered at 250 mg twice weekly, doxycycline at 100 mg twice daily, and vitamin C at 500 mg once daily”

Here are the folks I know about from following this thread; are there others who would like to make themselves known?

KFISH: std protocol - rapa/all supplements paused - ended 11/1/23. Finished “DAV” ‘reported no side effects, blood test came out perfect same as usual there was no changes to any longevity blood markers.’
约瑟夫 : modified protocol - doxy 3X/day, azithro every 72hrs, ~2g Vit C 3x/day (4 hrs after taking doxy or azithro) - not on rapa at time - ended 10/31/23
blsm: modified protocol - 50mg doxy, std azithro, 140mg Vit C (vacsorbyl palmitate); later increased acsorbyl palmitate to 500mg - post doxycycline - end 11/17/23
Danlalane: std protocol - continue rapa - ended after day 9 (" I feel my GI and gut microbiome are taking a hit.“)
Rmun: modified protocol - 50mg doxy 2x/day, 1g Vit C/day - end ??
Walter_Brown: started 10/24 " I have multiple sclerosis (which is in long term remission due to Mavenclad), I have suffered from continuous neuropathic pain and stiffness in my legs. I am not sure which part of this DAV therapy is being effective (anti-inflammatory or autophagy or both), but the stiffness is gone and my pain is (and continues) decreasing.” (reported 10/30) improving skin? (reported 11/3)
DrT - pending more info about effects for those with AF
Vjha: std protocol - ended 11/1/'23
Lowroad: will begin soon
desertshores: Started 10/22
Mogli: started/stopped after a week (“i stopped DAV after one week because DOXY was giving uncomfortable upper stomach pain, but also wanted to add I felt bloated a bit, and seemed like I wasn’t digesting food as good as before”)
Goran: ended ??? a couple days early; pills ran out. No side effects from DAV whatsoever. “Two thumbs up from me”.
essexaid: standard protocol, but 700mg vitamin C powder.
J0hn: 50mg Doxycycline (Dr Reddy’s Doxycycline Hyclate and Lactic Acid Bacillus Capsules) twice a day, 500mg Ascorbyl Palmitate, 250mgs of Azithromycin twice a week.
SNK: standard protocol, stopped after 1 week due to stomach issues.
jjrap1: will start 1/'24

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#166

Std, not stopping Rapa. Started 10/12, ending 11/16.

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#167

@jjrap1, I’m doing it modified with 50mg doxycycline every 12 hours and 140mg acsorbyl palmitate every 12 hours post doxycycline. I historically do not tolerate the full dosage of doxycycline well (disrupts my sleep) or high doses of vitamin c so that’s why I personally modified it. I’m keeping the azithromycin at 250mg every 3 days/72 hours. I haven’t decided on whether to pause rapamycin yet. :slight_smile:

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#168

That’s the only thing that is holding me up from starting: the issue of cardiac complications from Azithromycin. I had Atrial Fibrillation (have had ablation). Trying to find more info on the risk for me.

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#169

I was not on rapamycin at the time,I cycle on and off.

In one of the other posting I said I was going to start rapamycin on October 1, but decided to do the DAV.

Just thinking it may be better for the removal/
eradication of senescence cells and CSC .
Same reason that I increase the doxycycline dose/ made a tighter window 8 hours instead of 12 and higher Vitamin C . To increase removal/
eradication of senescence cells and CSC.

Yes, a leap of faith the paper and work published is correct or mostly correct.

The possibility of the potential benefits {as published) is high and risk in my view is low.

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#170

Will let you know once I start. Am expecting this to be around 30th October as I’m finishing a post-cycle therapy I do to aid my rehabilitation. Will update you on protocol & rapa use/pause then. Following all already trying DAV eagerly :slight_smile:

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#171

I paused Rapa and all other supplements while on DAV. Std protocol.

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#172

I took my rapamycin today so I suppose I’ve made my decision. I’ve been taking rapa at 3mg/week (100 pound female). Recently I shifted to 1mg on Mondays and 2mg on Thursdays just because I like how I feel with more frequent dosing but 1mg every other day seemed a bit too much over several weeks time. This dosing schedule seems the best compromise for me. Ideally as a smaller person I would like to eventually switch to 0.5mg and try taking that amount more frequently. So far I’m feeling really good on DAV with nothing negative or positive to report but it’s only day 3.

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#173

Do you feel that your weight goes down with rapamycin? Mine does. And it’s difficult to gain weight no matter how much I eat. I was 112 lb, and lost 5 lb with my recent viral infection. Trying hard to gain it back, but it’s stuck at 107 lb.

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#174

That’s impossible unless the laws of physics can be broken. Simply you are eating too few calories or using too much with exercise.

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#175

Yes, it’s like my stomach has shrunk. I can’t over eat, ever. And I’m just not very hungry. I actually hit 151 lb last week and decided to start making myself eat more.

#176

It’s possible, regardless of physics. I eat all day long and do not exercise that much. Rapamycin mimics starvation. What are your thoughts about that?

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#177

Check Ethan Sims experiments at Vermont State Prison during the 60s and 70s. From what I can recall same calories in did not equate to same weight gain. He recruited inmates to eat as much as they could to gain 25% of their body weight, in return for early release from prison. Some of the volunteers could not reach the target however hard they tried, even though they were eating 10,000 calories a day. Sims’s conclusion was that for some, obesity is nearly impossible

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#178

Did you weigh more before Rapa?

#179

There’s a lot of things wrong with that study which is expected as it’s an old one, but they did not feed inmates the same amount of calories and neither would that make any sense as people burn a different amount of calories, dependent on body weight, for example. They didn’t show how many calories each subject ate either. That’s only one problem. You can try and find a more recent, better study, if you want.

No it’s not possible, you don’t gain weight because you don’t eat enough calories. As soon as you start tracking your calories you will know. Try a 20 or 25% increase over your daily calorie needs with a lot of protein.