I downloaded the full article, and searched for the phrase “liver damage”, and below is what is written:
“The phenolic compound, curcumin is known for its anti-ageing properties
(Lee et al., 2010). However, recent studies have suggested that its low
bioavailability in the brain following oral administration, limits its
usage and in long term, leads to liver damage (Qiu et al., 2016).
Currently, EGT is gaining more attention for its anti-ageing properties.
Past studies have shown that despite possessing hydrophilic properties,
EGT is highly distributed in the brain due to the presence of a specific
transporter that enables it to cross the BBB (Ishimoto and Kato, 2022). A
pharmacokinetic analysis reveals that after oral administration of EGT,
it is distributed to the gastrointestinal tract, followed by the liver and
that hepatic blood flow is responsible for the ubiquitous distribution of
EGT to other organs which express OCTN1, including the brain (Kato
et al., 2010). To the best of our knowledge, EGT is highly retained in
body tissues and excreted out from the body at a slow rate (Cheah et al.,
2017) implying a more sustained function unlike other polyphenols
(suggested as an antioxidant) which are rapidly metabolized and
excreted out from the body.”
Page 2, bottom left column , to page 2 top right.
The citation points to Qiu, and the entry says
Qiu, P., Man, S., Li, J., Liu, J., Zhang, L., Yu, P., Gao, W., 2016. Overdose intake of
curcumin initiates the unbalanced state of bodies. J. Agric. Food Chem. 64 (13),
2765–2771. https://doi.org/10.1021/acs.jafc.6b00053.
Reddy, H.P., Reddy, P.T., 2011.
