Most Heritable Complex Traits Are Extremely Polygenic (lots of genes)

[AnUser]

Here’s a talk refuting the common misconception that complex traits are determined by few genes with large effect sizes.

For example you can’t upload your DNA to a service that says you have a “social anxiety gene”, it can say so but it’s false, you need a service that consider all of your genes, like Nebula with polygenic risk scores.

Blood pressure, extremely polygenic (genes that are statistically significant is colored dots above the red dotted line).

MPG Primer: Heritability and SNP-heritability (2020)