Re Fahy and Thymus-epigenetic age:
Reversal of epigenetic aging and immunosenescent trends in humans
The cocktail included growth hormone, of which everything I’ve read, is NOT pro longevity (I know Dr Green is most definitely against it as a longevity intervention)
Although tinkering with the thymus, is indeed a fascinating pathway.
“Naked mole rats display no thymic involution up to 11 years of age. Our observations suggest that naked mole rats display a delayed immunosenescence. Therapeutic interventions aimed at reversing thymic aging remain limited, underscoring the importance of understanding the cellular and molecular mechanisms behind a sustained immune function in the naked mole rat”
Naked mole rats don’t age…they just reach end of long life and keel over.
A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence
“Low circulating levels of specific amino acids, particularly those linked to the methionine pathway, resemble those observed during the fasting period at late torpor in hibernating ground squirrels and those seen in longer lived methionine-restricted rats. These data also concur with metabolome reports on long-lived mutant mice, including the Ames dwarf mice and calorically restricted mice, as well as fruit flies, and even show similarities to circulating metabolite differences observed in young human adults when compared to older humans”
Somatic mutation rates scale with lifespan across mammals
(btw, GREAT paper illustrating that longevity is a function of somatic mutation rate. I wrote to the author asking if mTOR inhibition would reduce somatic mutations, hence, a primary reason for the pan species longevity enhancement of Rapamycin (still waiting!). Most especially cancer which is a mutation intrinsic disease, of which mice have shown in repeated studies, treatment with Rapamycin delays cancer induced mortality.
The naked mole rat is king at punching way above it’s weight re size/longevity!
