This may be interesting.

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covered in AAAS annual meeting right now! [mitochondrial transplants to treat mitochondrial dysfunction]. Can healthy cf-mitochondria be infused into aged humans to rejuvenate them?

a lot of lehigh and scott pletcher NUDFs KO syndrome stuff - tthis reminds me of so much of what kaeberlein lab people talked about long ago [eg bitto]

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Intercellular Mitochondria Transfer to Macrophages …

[image]
National Institutes of Health (NIH) (.gov)
https://pubmed.ncbi.nlm.nih.gov › …
](Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity - PubMed)

by JR Brestoff · 2021 · Cited by 253 — Recent studies suggest that mitochondria can be transferred between cells to support the survival of metabolically compromised cells.

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The power and potential of mitochondria transfer

[image]
National Institutes of Health (NIH) (.gov)
https://pubmed.ncbi.nlm.nih.gov › …
](The power and potential of mitochondria transfer - PubMed)

by N Borcherding · 2023 · Cited by 127 — We discuss the role of mitochondria transfer in regulating cellular metabolism, cancer, the immune system, maintenance of tissue homeostasis, mitochondrial …

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A guide to studying mitochondria transfer

[image]
Nature
https://www.nature.com › nature cell biology › comment
](A guide to studying mitochondria transfer | Nature Cell Biology)

by S Tiash · 2023 · Cited by 16 — Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering the circulation.

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Adipocyte to macrophage mitochondria transfer

[image]
Nature
https://www.nature.com › … › research highlights
](Adipocyte to macrophage mitochondria transfer | Nature Reviews Endocrinology)

by A Kriebs · 2021 · Cited by 3 — “Several studies show that mitochondria can be transferred between cells,” explains Jonathan Brestoff, lead author of the study. “This made us …

Videos


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56:26


Mitochondria transfer with Jonathan Brestoff, MD, PhD, MPH
YouTube · Cure Mito Foundation
1 month ago


[image]


36:26


[Jonathan Brestoff] Intercellular Mitochondria Transfer to …
YouTube · Open Box Science
Feb 25, 2022


[image]


1:02


Mitochondria transplantation between living cells
YouTube · ETH Zürich
Mar 28, 2022

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](brestoff mitochondria - Google Search)


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Dietary lipids inhibit mitochondria transfer to macrophages …

[image]
Cell Press
https://www.cell.com › cell-metabolism › pdf
](https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00353-9.pdf)

by N Borcherding · 2022 · Cited by 84 — Previous studies indicate that HS (Brestoff et al., 2021) and CD36 (Rosina et al., 2022) mediate mitochondria uptake by macrophages. We found …

24 pages

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A LOT of it from adipose tissue to macrophages to endothelial (high-fat inhibits this)

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Does mitochondria in legs move to other places in the body, or does exercise stimulate mitochondrial density and function in other areas of the body? (exercise impacts the density and function of mitochondria in legs, as measured with muscle biopsy).

This sounds like an important breakthrough:

https://scitechdaily.com/regenerative-medicine-breakthrough-new-method-creates-854x-more-mitochondria/#comments

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