An international study led by the University of Granada (UGR) has revealed that melatonin, known for its ability to regulate the sleep/wake cycle, can restore the composition of muscle fibers and protect skeletal muscle from damage caused by obesity and type 2 diabetes, known as “diabesity.”
The results, published in the journals Free Radical Biology and Medicine and Antioxidants, show that this hormone improves mitochondrial function, reduces cellular stress and prevents programmed cell death, offering a new therapeutic strategy to combat this metabolic disease.
More information: Diego Salagre et al, Melatonin induces fiber switching by improvement of mitochondrial oxidative capacity and function via NRF2/RCAN/MEF2 in the vastus lateralis muscle from both sex Zücker diabetic fatty rats, Free Radical Biology and Medicine (2024). DOI: 10.1016/j.freeradbiomed.2024.12.019
Diego Salagre et al, Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats, Antioxidants (2024). DOI: 10.3390/antiox14010016
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Its mode of action for these things is not as a hormone though.
Beth
#333
I don’t think I’ve seen this source listed anywhere for high dose melatonin capsules, so here I am.
In the comments of the video you posted, I noticed Ryker Black buys his melatonin from Pure Bulk. I then discovered Pure Bulk also sells 100mg capsules with no fillers.
(You can select powder or capsules, so pay attention to that option).
You can sign up for 12% off your first order. That makes it $45 for 120 caps of 100mg.
FWIW, last night I took my highest dose yet at aprox 100mg, and coincidentally or not, I had one of the best HRV scores I’ve had.
I did that by swallowing too many chewables (blech, will not be doing that again, my tummy is not happy) so I’m looking forward to more experiments with the caps. My sleep is pretty good these days anyway, but I see a positive difference in my stats when I take extra.
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adssx
#334
Mechanism of arsenic regulation of mitochondrial damage and autophagy induced synaptic damage through SIRT1 and protective effect of melatonin 2025
Arsenic exposure can cause synaptic damage, which can lead to neurotoxicity.
Arsenic exposure regulates mitochondrial damage through SIRT1 and activates autophagy leading to synaptic damage
The neuroprotective effect of melatonin may be due to the prevention of SIRT1-mediated mitochondrial damage and autophagy activation.
No mention of DNA.
mtDNA is hard to measure.
adssx
#336
Melatonin seems to be able to reverse age-related SBR decline
The question is the optimal dosing and timing:
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I still tend to take melatonin during the night although I do take some when I am drinking as well.
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LaraPo
#338
Why not to stop drinking? It doesn’t contribute to your longevity nor to being a good role model, John.
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Why do i have to be a role model?
LaraPo
#340
You don’t have to, but you just are.
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As someone who has a mild (so far) case of RLS, I have shied away from melatonin. There is an interesting connection between RLS and PD, so the role of melatonin is all the more intriguing in both disorders, I sense this disparity might be a fruitful research avenue that might reveal something about both.
Restless Leg Syndrome and Melatonin
Linking restless legs syndrome with Parkinson’s disease: clinical, imaging and genetic evidence
adssx
#342
I wouldn’t conclude much based on an n=8 trial without placebo.
adssx
#343
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Beth
#344
I thought I’d share that with my new bottle of Pure Bulk 100mg pills, I’ve experimented with taking 1200mg on two different nights.
I took 12 pills all at once, right before I went to sleep.
I based this number on watching the Ryker video from above which contained excerpts from Dr Loh. She said if one is 50, take 180mg, and then add 100mg for each additional year. I through in a little extra to be, you know, extra.
She says if you take enough, you wake up full of energy, but I found myself dragging those two days.
On a few other nights, if I didn’t take any at all but woke up in the middle of the night, I’d take 100mg and it does work like a champ in helping me fall back to sleep.
Is there any more experimenting to be done? Meaning, should I be breaking up the 1200mg dose or even adding more? I don’t want to blow through this bottle of pills if high dosing just isn’t for me.
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Nlo
#345
I have 5 mg dissolve tabs and 20 mg capsules. I’m taking about 40-60 mgs nightly. With melatonin, I sleep better, get up to the bathroom much, much less (which is a true miracle), and I feel less stressed if/when I do wake up.
Sleep is important, so in the past when I would wake up, I used to lightly fret, get up to use the bathroom repeatedly and/or determine what I needed to take to get back to sleep (Sulforaphane, ashwaganda, magnesium, etc). Melatonin seems to take away my anxiety both at night and in the day, so even if I have a more restless night, I’m just not feeling distressed or negative about it.
I’m still fairly new to melatonin, but I will slowly experiment with increased doses because it’s been a game changer for me. Thanks for sharing the formula that you are following, Beth.
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An experiment is to take presleep melatonin say 2-3 hours before bed. I generally only take it on waking during the night
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There is an interesting question as to the pharmacodynamics of high doses. I think the half life gets reduced, but I have not done the testing to know.
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adriank
#348
I still haven’t found a practical way to take 1000mg a day. Just too many 20mg pills drives me nuts. Maybe one day.
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Beth
#349
Incase it helps, I found 100mg pills from pure bulk. Not inexpensive if you are going to take 1000mg per day, but an easy way to experiment with it, as I am. The pills are tiny, too.
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There are 60mg pills. I also tried a few grams during the day I had dissolved in whisky. That did put me to sleep for a few minutes. Not sure it was the melatonin though.
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