#1

What is your experience with melatonin immediate (IR) vs slow/extended/prolonged (SR/XR/PRM also branded as Circadin) release?

The PK of PRM seems closer to the physiological one:

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Source: Melatonin: is it worthwhile for sleep? bpacnz

However another paper found smaller differences after 6 hours:
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Source: https://www.tandfonline.com/doi/full/10.1080/19390211.2023.2206475

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