Fortunately… understanding HRT/TRT in men and woman has come a long ways. It is basically safe. Both Dr. Peter Attia and Matt Kaeberlein said HRT in men and women is a #1 out of 5 in health benefits.
Quote: Data is clear… in magnitude of effect. Safe for men and women under a physician’s care. It’s a #1.
Podcast - Peter Attia and Kaeberlein: Training Eating & Optimizing To Live Longer. End of program at point 1:02:48
Link: https://youtu.be/HkmF8VwU2EI
Also, blood test for Testosterone levels is measured in what a normal healthy range for a person. Above that range is steroid dosing. Under that range is adjusting within normal. For Labdaq that does my blood measurement normal range of testosterone is 199 - 1586. I am well under that in my test this week at 1177.7.
Yes - over 1586 you begin to move into above normal and steroid abuse level. Why you use a physician.
Blood test this week for sirolimus/ rapamycin/rapamune – estradiol and testosterone
My Estradiol level is also great 25.7 you need this hormone - but don’t want it too high. Which is why you do blood tests regularly and work with a physician - as Attia and Kaeberlein recommend.
Link: The Role of Estrogen in Men’s Health.
What estrogen level should a man have?
The normal estrogen level that a man should have depends on his age and medical history. A fully grown male usually has an estradiol level of 10-40 picograms per milliliter (pg/ml)
The presence of estrogen in a man’s body is extremely important, since they perform several important functions at once, including:
- ensuring that muscle mass gain is processed in the correct way
- preservation of bone strength
- maintaining a stable nervous system and emotional state
- maintaining the correct metabolism
- prevention of the development of muscle and organ hypoxia even with strong physical exertion
- prevention of the development of diseases of the cardiovascular system
- maintaining the normal appearance of the skin
Hopefully with the better understanding HRT of achieving high normal testosterone with TRT for health - we stop scaring those who can benefit most from it as a healthy aging option. I was under the same illusion of - "IT WILL KILL YOU!! Until I discussed it with my physician and he explained that is not true for adjustment within normal. Been on TRT 5 years now. GREAT!!
As to my sirolimus number 17.3 normal range is 3-20 ng/mL
That was from 10 ounces of GFJ grapefruit juice 2 hours before a dose of 4 mg zydus/rapamycin taken with 5 ounces of GFJ with the pill . Labdaq blood test drawn was 2.5 hours after zydus/rapamycin dose.
It seems for most people 1 mg rapamycin = 3 ng/mL. Hence the normal range of 3.0 - 20.0 ng/mL Meaning you could take 7 mg and likely still be in the normal range.
Taking 4 mg with nothing should have given me a 12 ng/mL, but with the GFJ I was able to get the benefit as if I had taken 6 mg which would be about 18 ng/mL.
I want to take 6 mg rapamycin per week - so the GFJ saves me one 2mg pill. Which is great!!
I had assumed the GFJ would have a bigger effect - but hey - this is fine take 4 mg with GFJ - get a benefit of 6 mg.
