Just over 2 years on Rapa and physical training advances continue.

Photo on left - Katalyst EMS suit (no affiliation just an early adopter).
Photo on right - Me at 72, 199 lbs.

Some way to go to catch up to Agetron, but he has a few years on me ;-).

Katalyst suit 2 twenty minute seasons per week.
Mobility work almost daily.
10k steps daily average.
Occasional workouts on cross country ski machine.
Timed static contractions maybe once a week (squat, dead lift, overhead press, shoulder shrug).

Rapa doesnā€™t seem to have affected my ability to build/retain muscle.
That said, I have begun to consider TRT.

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Fantastic news - thanks for the progress report. Seems like youā€™re on the right path for healthy longevity. How are your blood biomarkers? LDL-C/APOB, A1C, etc.?

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Great going @Alpha keep us updated on your progress!!!

Again, excellent job. :grinning:

Great job! I hope I look half as good at 72.

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Hahaha Andreasā€¦ niceā€¦ very nice. No body shame at the beach for you! Youā€™re killing it!

And for my 2 cents worth of adviceā€¦ get on TRT and see more body toneā€¦ better skinā€¦ fat reductionā€¦stronger muscles and bones.

TRTā€¦ keeps you in a normal rangeā€¦ not steroids out of control. Replacing what you are losing. Then we can have a muscle pose, show-downā€¦ :muscle:.

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LDL typically ranges from 60-70
HDL +60

Donā€™t remember my LDL-C/APOB but nothing unusual.
AIC center of normal range.

Coronary calcium score = zero.

All-in-all mostly good.
Biggest issues from autoimmune:

  • mild seasonal allergies (much worse in the past)
  • psoriasis (mostly manageable)
  • cervical stenosis from some combination of old injuries and arthritis (having some success with PT)
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My seasonal allergies that I never had until 50 years oldā€¦ (after that 40ā€™s aging spike I guess), are now completely gone. Had cedar allergies in Marchā€¦ ragweed in September.

Allergies were gone after my first full-year on rapamycin. For past 3 years allergy and pretty-much illness free too.

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calcium score zero! wow. how is it I read about all these people with CS of zero yet I have always watched my food intake type, exercise religiously and have been on statins for 3 decades and my last score at 64 yrs old was 44. not horrible but pretty depressingā€¦sigh.

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Consider that a calcium score from a CAC test can only tell you about calcified plaque. It cannot say anything about soft plaque, which in many ways is more dangerous. One way in which it is thought statins help with MACE is by calcifying the soft plaque, thus stabilizing it, and preventing the dangerous soft plaque rupture and the subsequent artery blockage. Statins elevate your calcium score. If youā€™ve been on statins for decades, it is not shocking to have a greater than zero calcium score, itā€™s not extremely worrisome . The only question remaining is the degree of stenosis, and here you might consider a CIMT for some insight. CIMT is non-invasive, and not especially expensive out of pocket, though somewhat operator dependent. I have a zero CAC score measured at 65, and Iā€™m having a CIMT early next year to help me make a decision about trying to crush LDL below 50.

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I started on statins back in 1989. One would think that if statins increase the score then that could be factored into the end result/score? I have had a number of echocardiograms, most recently in Nov and " no evidence of stenosis" nor any prolapse was rife throughout the report.(mitral valve, aortic valve, pulmonic valve, tricuspdid valve, etc.) and my overall global ejection fraction is 55% my cardiologist says my heart is in great shape although I do have minor skipped beats now and then (thatā€™s what I call them, they call them premature ventricular contractions) but they sure feel like skipped/missed beats to meā€¦Iā€™ll talk to them this Jul on my next annual followup about CIMT. heck; I might even had one done as I remember them doing some test on my carotid arteries.

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Not having stenosis is very good news. CIMT as you know, is not simply about the carotids, but is a proxy marker for general plaque levels in the arteries. If you carotids are narrowed, odds are there is atherosclerosis elsewhere too, and the other way around. Ultimately, you could spring for an angiogram, these days they have fancy software that can compute all sorts of evaluations and prognosis - of course, it does cost a pretty penny out of pocket, but thatā€™s the gold standard if you want peace of mind, or want to know whatā€™s going on.

Iā€™ve always tried to eat well, exercise intensely, and supplement using the best knowledge available to me through my life (still at it).

Of note, I had very high cholesterol (total 325+) since a teenager. Iā€™ve only recently started Crestor thinking of the long run.

A lot of this comes down to luck and genes. More the curious because:

  • My father died at 69 from leukemia in 1972, but his autopsy found he had advanced cardio vascular disease.

  • My mother, died at 62 in 1982 from a heart attack.

  • My brother, died at 42 in 1983 from a heart attack, but he had advanced metabolic disease, (lost a leg to vascular disease/diabetes), early onset Alzheimerā€™s, and had a couple of strokes (big guy, 6ā€™4", former football player, 300+ lbs) - everything went wrong.

Somehow some combination of genetics and maybe epigenetics has spared me their troubles.

I know the luck life has afforded me and generally try to do everything I can to honor it and make the most I can out of it.

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I like that 2 cents.

Can you tells us more about your TRT regimen.
Dose, type, frequency, how you made the case to get it?

Thx.

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Iā€™ll speak to them in Jul on my annual checkup about CMIT. Iā€™m starting to think I had one done during my many tests when I went to them for ā€œskipped heart beatsā€. Iā€™m pretty positive I had some sort of test done on the carotids

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You doing great on your daily steps. That said you do strength training only once a week. Increasing frequency and intensity may be beneficial especially so now that you are considering trt. Talking about replacement therapy why not consider hgh/semorelin too?

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Sigh, there is nothing fair about genes!

I know plenty of people with a zero, including my husband who ate fast food daily until he married me at 40. I say, god gave you a good heart but at least he made me funny, so thereā€™s that :slight_smile:

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To the contrary, the Katalyst suit (twice a week) provides high intensity strength training. A 20 minute sessions engages 90% of oneā€™s muscle. Done properly (raising intensity regularly) one canā€™t handle additional frequency or other strength training.

I do timed static contractions principally to put my skeleton under load.

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Some additional benefits are not just load on the bone, but shock. Thatā€™s how Whole Body Vibration therapy works. Bone benefits from jarring, as when you run - the bone density in the legs of runners is increased. Apparently there are also muscle benefits and even gut microbiome and glucose control benefits to WBV, there was a whole thread on that on the crsociety.org (RIP) website back in the day. The other aspect of course is the neuromuscular and CNS training that happens with a physical workout, in addition to things like balance and coordination. Iā€™m not saying the suit is bad in any way, itā€™s certainly very helpful, just that the traditional approach too has its uses.

Interestingly you only need to run or skip a rope for 2 minutes every day to increase your leg bone density and protect yourself from risk of hip fracture when falling.

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Sure, Andreas! A story I hope motivates those on this site. You can turn your health around - even if you feel it is a lost cause. For those younger, maybe a cautionary story to stay fit.

I went through my computer to provide a pictorial journey of my body and health transformation.

So, we start at the beginning of my health journey at age 58 years. I had not worked out since my college years and bit-by-bit over the decades, I had become complacent with my dad bod. Wait - - not a dad bod - which is kinda sexy - I was truthfully obese! I decided to change and asked my son to take a front and side pic of me. He asked why? I told him because I was going to change myself and wanted a pic to remember the old me - he laughed and said, ā€œSure, - you look gross, and it wonā€™t happen.ā€

Eating less and walking 3 miles most days I lost 30 pounds in about 4 months. I was pretty skinny now.

Jason running 1

So, I took a pic the day I started working out to put on muscle. I can see nowā€¦ why everyone thought I had cancer due to the sudden weight loss. It seemed to me by gaining muscle I could put those rumors to rest.

But, after doing consistent muscle resistance exercise for 3 yearsā€¦ I was more in shape - finally a dad bodā€¦ and a bit of arm definition, but lacked real strength or muscle definition. I had plateauedā€¦ stuck.
My blood panel for testosterone was at about 420ā€¦not crisis levelā€¦ just short of it though! My previous physician said you are getting olderā€¦ thatā€™s what happens. Done with that!
My new physician said TRT takes you to a higher within range normal. Here is a pic the week before starting TRT. Again, I wanted to document the change. Boy did I change.


Gym for 3 years age 61 years ā€“ 2019

I use once weekly injection in my thigh 200 mg 1 ml Cypionate testosterone - with 1 mg anastrozole (now 5-years).

Image of within 4 months I could see significant muscle growth and toning of fat.
I grow out my beard and put on 25 pounds of meat.

Energy and libido greatā€¦ felt fantastic. But I was having the beginning of arthritis, memory decline, dysphagiaā€¦ crepey skin. TRT was not slowing my aging. I started researching and locked onto rapamycin. My same physician, who had gotten me up to 1,400 testosterone (upper normal range) after a year, looked at my rapamycin research and said - no real side effects - if you donā€™t feel good - stop and it will wash out in a week. So, I started my rapamycin journey in August of 2020. After 3 months of rapamycin weekly use of 6mgā€¦ I began losing a pound off my weight every few days and by the end of the month lost about 20 pounds. Most of that weight loss was from invisible, visceral fat around my organs. Yet my arms, chest, thighs, and butt had all the muscle. TRT brought me muscle size - Rapamycin compacted those muscles and shredded me ā€“ pure muscle and no marbleized muscle or extra fat in my body.

Continuing TRT 200mg/1ml weekly and rapamycin 6mg weekly I have grown in strength ā€“ lifting more weight than ever and increasing my workout load every 3-4 months. After several years - I am very tight and strong compared to my beginning pics. My biological tests (Glycan -inflammation and TruMe-DNA Methylation) say I am between 40 and 50 years. Arthritis gone, skin toneā€¦ memory off the charts. Feeling amazing.

I think the images give a good overview of my changes from heavy to thin to muscular to tone shredded. Everyone makes choices for health, energy and strength I believe the TRT and rapamycin have put me into a very healthy weight and size.

You can be thisā€¦ strong, healthy, pain free, energetic and quick mindedā€¦

or this!

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