A great story of personalized medicine where the detective work led to succesful precision interventions tailored to the individual’s unique biology. Unfortunately is that many Drs don’t have time (or interest) in this kind of creative problem solving.

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I am 73 5’9” 173lb
Rapamycin 8mg weekly for 12 weeks off 4 weeks Using for 8 months with wife. No negative or positives were noticed.
Is the catalyst worth it?
I have used testosterone for 20yrs. Now keep levels around 600

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To what catalyst do you refer?

Hoping not to get too off topic, but I wanted to mention I got rid of my skipped beats (PVCs) by taking 4.5 mg low dose naltroxin

@agetron. Your dose of testosterone is much higher than a standard HRT dose. A reasonable 1st steroid cycle for someone would be 400mg T per week. A very reasonable HRT dose is 100mg/week. At 200mg/week I’d be curious what your peak and trough levels are? Surely >1000 ng/dl?

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Yes. At almost 67 years (in a few months) peak is 1400 - 1480 range on my Blood panel that is high within normal. I know Europe or at least the UK uses a different measurement. Can’t compare apples to oranges.

My trough is 800… been using 5 years now… so pretty consistent. Blood test and T measured every 4 months. Many on this forum on TRT in their 60’s are at a similar dose.

Those in 50’s are at the dose you identify at 100 mg weekly.

No noted issues. My physician keeps me at highest normal in most categories like D; B-12 and such.

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I use hundred milligram daily for five days on two days off. It’s a transdermal cream from the pharmacy. I have my numbers checked by my urologist every year at 73. I’ve reduced my target to 500

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Katalyst exercise suit

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I certainly think so. Reasons follow.

I principally use the suit for strength training. Two 20 minute sessions per week.
Katalyst has additionally developed training protocols for power, aerobics, flexibility, recovery, and free form.

Setup

One needs an iPad or cell phone to run the sessions.
One needs to wet/soak the stimulation pads on the suit prior to staring a session.
This can take 5-7 minutes before you can star a workout.

You use hot water, but strapping on a wet suit could take a bit of deliberate disciple during a cold winter.

Strength & power

The strength and power training sessions supply 4 seconds of stimulation followed by 4 seconds without stimulation over the 20 minutes. Katalyst suggests synchronizing one’s breathing to that rhythm. Intensity increases through the session. One can adjust the overall intensity as well as the intensity of the stimulation of specific muscle groups.

The sessions have accompanying videos that take you through a series of exercises some calisthenic like, some body weight like, some weight lifting like. The idea being your muscles get stimulated over the range of motion.

I sometimes turn on the video and do my own movements, e.g., I use a 5’ aluminum bar and do power cleans and thrusters or other movements for the 20 minutes.

The suit makes it easy to replicate progressive loading. Just dial up the starting intensity 2.5%-5% each session. In practice I adjust increasing intensity relative to the recovery data I get from my Oura ring.

I’ve trained in Olympic lifting, CrossFit, power lifting, Nautilus, and Superslow. I find the Katalyst strength training workouts the most intense of anything I’ve ever done. Katalyst claims its suits stimulate 90% of one’s muscle mass. It certainly feels that way.

Aerobics

Base sessions of 20-30 minutes, but one can extend or just repeat them. These sessions provide a constant stimulus while you engage in some aerobic activity e.g., walking, running, biking, rowing, or X-country skiing (any of these either out in the world or on machines). The use of the suit just intensifies what you already do so you metabolically place greater demand on your body in the time you have. Kind of like going for a walk with weights in a back pack.

Flexibility

More recently introduced, the Katalyst flexibility sessions can enable one to load stretches, e.g., go to one’s limit in a stretch, stimulate the muscles, then release into a deeper stretch.

I think Katalyst could optimize this better. A number of the training videos they have available, look mainly like yoga in the suit - OK, but not using the kinds of advanced flexibility training now available.

Recovery

I use the recovery sessions after strength sessions whenever I have time. I also like to use them a day or even two days after a strength session to address delayed onset muscle soreness.

The recovery sessions supply a continuous kind of percussive feeling that gradually increases in intensity over a 20 minute session.

Think of it as a (nearly) whole body massage suit.

Free form

The free form sessions have no corresponding video, but 20 to 30 minutes of 4 seconds of stimulation followed by 4 seconds without stimulation. Some of the free form sessions will increase intensity over the session; some keep the intensity constant.

I find these the most interesting. You can develop your own strength, power, or flexibility routines.

Training while injured or impaired

Given my age, my history of (i) doing physical things at an intensity level probably beyond what I should have attempted and (ii) 73 years of wear and tear, and injuries the Katalyst suit has enabled me to train at very high intensity even while injured.

As example, while I’ve reported in other threads that I have repaired|restored cartilage damage from a botched meniscus surgery, I still feel wary of doing heavy squats and deadlifts.

The Katalyst suit enables me to do the movements with the benefit of high intensity muscular stimulation while not risking further injury.

Customer support

I’ve used the suit for nearly 3 years. I originally had one of the earliest models - pre wide spread marketing. I had some issues with the battery pack, some stimulation pads failing, parts of the suit delaminating. Katalyst support replaced everything, with only clarification questions asked.

Impressive.

What else I’d like

I’ve suggested that Katalyst set up a users forum, from which it could glean improvements and from which users could discuss and develop programs, protocols, workout optimizations for using the suit.

Seems knuckleheaded (a technical term;-) that they don’t. It would cost them almost nothing to set up and review once in a while.

I’ve found a Reddit discussion, but I haven’t found it well attended.

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I just got Blood Flow Restriction (BFR) cuffs
Too early to see any results but that’s working very well to reduce the oxygen in the muscles.

I exercise with a muscle oxygen sensor (Moxy) and I was shocked to see my quads oxygen going down to 0% while doing reverse nordic curls!
The lowest I’ve seen it was around 7% in very hard hill sprints which are only sustainable for a few seconds and then the oxygen goes back up.
With the BFR cuffs it can stay very low for minutes which is going to have a tremendous impact on the muscle. That’s the theory at least.

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How did you come to using naltroxin for PVC’s? Did your Dr give it to you for off-label use for PVC’s? I don’t see any references online for it being used off-label for PVC’s.

I’ve been thinking about getting BFR cuffs too. Let us know how it goes. Did you only get them for the legs, or did you get them for the arms and legs (or can you use one set for both arms and legs?)

Related: Blood Flow Restriction Muscle Training for the Intervention of Sarcopenia

I have both legs and arms sets. You can’t use them interchangeably unless you are a bodybuilder with biceps like my quads. :slight_smile:

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Low-dose Naltroxin at 4.5mg is used for general inflammation mitigation and is considered off-label. I started it because I have Hashimoto’s and its suppose to help with that. I don’t know the actual mechanism that helped stop the PVCs: maybe the thyroid disease contributed, and so on. My prescription lapsed and the skipped beats started again.

TRT followup

I recently signed up with One Medical as a primary care service.

Interestingly, the doctor with which I work, said he can renew my Rapamycin prescription.
I think his decision, on this, follows from the length of time I’ve used Rapamycin without ill effects.

His actions confirmed this when I raised TRT. He became much more cautious.
Essentially he doesn’t want the responsibility of first prescribing TRT (he would likely renew if I already had a prescription).

He wants me to see an endocrinologist. This leads me to a question:

Does anyone here know an endocrinologist in NYC open to TRT for optimization of testosterone levels?

I know one can get online prescriptions, but I’d like to keep this doctor “onside” so I’ll honor his suggestions for now.

Recommendations appreciated.

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Wow… will sign off on rapamycin – a microbe produced substance. … but, no to testosterone a natural substance created in the body.

Shouldn’t be a problem this day and age… the positive benefits of maintaining high… but within normal T and now debunked side effects make it a no brainer.

All about medical liability assessment;-)

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Those levels are not in the normal range. Do what you want, but I am not buying that it is best for longevity.

  • LabCorp:
  • Adult males: 300 to 1,000 ng/dL
  • Quest Diagnostics:
  • Adult males: 300 to 1,000 ng/dL
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It is in normal range for my testing group… you get flags when you are too low or too high… over the range. I don’t understand dismissing the scale… which gets adjusted periodically. The scale is based on your company that screens LabCorp, Quest, Labdaq. Same for BMI, DEXA lumbar score… or LDL-C . Normal is within potential of human population. Above would be steroid level. Getting retested on Friday.

Like vitamin B-12, D and creatine… my GP wants me (and I do too) at highest possible within normal.

But, yeah I agree to each their own based on their body and health.

I would like to do metformin… but totally rejected by my body. Tried multiple times. Acarbose works.

Just like those on here who can’t do rapamycin. There is that 5% that just can’t. Glad I am not in that group. I want health with longevity. Cheers!

Fortunately… understanding HRT/TRT in men and woman has come a long ways. It is basically safe. Both Dr. Peter Attia and Matt Kaeberlein said HRT in men and women is a #1 out of 5 in health benefits.

Quote: Data is clear… in magnitude of effect. Safe for men and women under a physician’s care. It’s a #1.

Podcast - Peter Attia and Kaeberlein: Training Eating & Optimizing To Live Longer. End of program at point 1:02:48
Link: https://youtu.be/HkmF8VwU2EI

Also, blood test for Testosterone levels is measured in what a normal healthy range for a person. Above that range is steroid dosing. Under that range is adjusting within normal. For Labdaq that does my blood measurement normal range of testosterone is 199 - 1586. I am well under that in my test this week at 1177.7.

Yes - over 1586 you begin to move into above normal and steroid abuse level. Why you use a physician.


Blood test this week for sirolimus/ rapamycin/rapamune – estradiol and testosterone

My Estradiol level is also great 25.7 you need this hormone - but don’t want it too high. Which is why you do blood tests regularly and work with a physician - as Attia and Kaeberlein recommend.

Link: The Role of Estrogen in Men’s Health.

What estrogen level should a man have?
The normal estrogen level that a man should have depends on his age and medical history. A fully grown male usually has an estradiol level of 10-40 picograms per milliliter (pg/ml)

The presence of estrogen in a man’s body is extremely important, since they perform several important functions at once, including:

  • ensuring that muscle mass gain is processed in the correct way
  • preservation of bone strength
  • maintaining a stable nervous system and emotional state
  • maintaining the correct metabolism
  • prevention of the development of muscle and organ hypoxia even with strong physical exertion
  • prevention of the development of diseases of the cardiovascular system
  • maintaining the normal appearance of the skin

Hopefully with the better understanding HRT of achieving high normal testosterone with TRT for health - we stop scaring those who can benefit most from it as a healthy aging option. I was under the same illusion of - "IT WILL KILL YOU!! Until I discussed it with my physician and he explained that is not true for adjustment within normal. Been on TRT 5 years now. GREAT!!

As to my sirolimus number 17.3 normal range is 3-20 ng/mL
That was from 10 ounces of GFJ grapefruit juice 2 hours before a dose of 4 mg zydus/rapamycin taken with 5 ounces of GFJ with the pill . Labdaq blood test drawn was 2.5 hours after zydus/rapamycin dose.

It seems for most people 1 mg rapamycin = 3 ng/mL. Hence the normal range of 3.0 - 20.0 ng/mL Meaning you could take 7 mg and likely still be in the normal range.

Taking 4 mg with nothing should have given me a 12 ng/mL, but with the GFJ I was able to get the benefit as if I had taken 6 mg which would be about 18 ng/mL.

I want to take 6 mg rapamycin per week - so the GFJ saves me one 2mg pill. Which is great!!
I had assumed the GFJ would have a bigger effect - but hey - this is fine take 4 mg with GFJ - get a benefit of 6 mg.

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