Is aspirin pro-longevity?

AlexKChen · 2023-07-11T17:48:31.133Z

Low-dose aspirin may increase anemia risk in healthy older adults

A large new study has found that healthy older adults taking a long-term low dose of aspirin may be at increased risk of developing anemia. The researchers say their findings suggest that these patients may need regular monitoring.

If you read Preston Estep’s mindspan, this is a good thing

Penguin Random House Canada

The Mindspan Diet by Preston Estep III, Ph.D. | Penguin Random House Canada

A comprehensive, easy-to-use guide to the foods that curb memory loss and improve cognitive longevity, this book will forever change how you think about diet and aging.

RapAdmin · 2023-07-11T18:05:22.841Z

lifeextension.com

The Mindspan Diet - Life Extension

Director of Gerontology at Harvard and author of The Mindspan Diet, Dr. Preston Estep explains the secrets of populations that live the longest with low levels of dementia.

The list of all compounds tested by the ITP and in progress is on the ITP website at Supported Interventions | National Institute on Aging. To date, six compounds have shown significant extension of lifespan:

Aspirin – males only (Strong et al., 2008);

en.wikipedia.org

Preston Estep

Preston "Pete" Wayne Estep III is an American biologist and science and technology advocate. He is a graduate of Cornell University, where he did neuroscience research, and he earned a Ph.D. in Genetics from Harvard University. He did his doctoral research in the laboratory of genomics pioneer Professor George M. Church at Harvard Medical School. Estep is an inventor of several technologies including DNA chip-based readout of transposon-based selections and universal DNA protein-binding microar...

Zanthous · 2023-07-11T22:07:45.938Z

I thought there was recent evidence showing long term use has a risk of heart failure.

J0hn · 2024-01-17T09:55:31.979Z

Anemia may not be a bad thing as far as aging is concerned ?

Iron: an underrated factor in aging

Yeah, well, here’s the thing: If you are on rapamycin your iron levels should be lower. Mine certainly are. "In turn, mTOR also exerts control over iron metabolism, and the inhibition of mTOR activity by rapamycin leads to inhibition of iron accumulation via the iron-regulating hormone hepcidin [10]. Transplant patients taking sirolimus (rapamycin) often develop a microcytic anemia, which has been linked to sirolimus-induced iron deficiency

Apologies if I haven’t done the link properly

MJT · 2024-01-17T16:34:20.008Z

The amount of evidence showing aspirin reduces risk of cancer is pretty substantial.

JuanDaw · 2024-01-17T17:36:13.255Z

https://www.acpjournals.org/doi/abs/10.7326/M23-0675?journalCode=aim

Anemia incidence in the aspirin and placebo groups was 51.2 events and 42.9 events per 1000 person-years, respectively (hazard ratio, 1.20 [95% CI, 1.12 to 1.29]).

Eight more incidences of anemia per 1000 person/years.

John_Hemming · 2024-01-17T17:43:05.721Z

I don’t like it because it is a Cox-1 inhibitor. It therefore reduces melatonin levels and disrupts sleep.

PubMed

Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans -...

Previous studies have demonstrated that some nonsteroidal anti-inflammatory drugs (NSAIDs), specifically aspirin and indomethacin, have acute negative effects on sleep in humans and animals. Whether this finding can be replicated and extended to...