Thinking of adding timolol to my stack. I already take 80mg of Telmisartan. I will closely monitor my BP so that isn’t my main concern (I know it’ll come with risks and will monitor).
My question is wider - any experience or knowledge of timolol?
约瑟夫
#146
Timolol - Continuing Education Activity
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adssx
#147
I wonder if the eye drops (normally for glaucoma) could do the job. Or the topical gel (normally used for infantile hemangiomas)
Jay
#148
Walter_Brown, that’s an interesting study you listed. I hope you find the galantamine beneficial. I’ve tried the Relentless Improvement brand a few times now and it does seem to have mild mental benefit, but tends to cause insomnia for me. So, I don’t take it at night. It’s seems to improve mental clarity when taken 4 mg with breakfast.
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Yes, I take it in the morning with 500mg of Metformin 
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Here’s the larger issue with that video - it references IL-11 inhibition in the context of life extension. And then the speaker claims that currently available molecules that can inhibit IL-11 to some degree, are lutein, resveratrol and curcumin or timolol. What’s wrong with this picture? Not one of these molecules has been shown - at this point - to extend life, and one (resveratrol) has been shown to not extend lifespan. So why are we talking about them in the context of life extension? They might extend healthspan (well, not resveratrol), or help with a specific disease, but not the one thing IL-11 inhibition is touted for, including in this video - lifespan extension.
While I personally am a big fan of lutein, and convinced by the literature that there are many benefits for eyes and brain at least, the mention of resveratrol is very undermining to any credibility whatsoever when it comes to health or lifespan - it has been so thoroughly discredited that it immediately makes me look askance at the video for touting it.
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Bicep
#151
This is an interesting avenue. Here are the papers referenced:
https://www.wellesu.com/10.1016/j.redox.2021.102020
https://www.wellesu.com/10.1016/s0006-2952(00)00544-x
Lutein seems like the best one to me too. Is there a test for IL 11? Probably not for the public use.
Bill fallon on IL-11 and ways to inhibit presently as well as a brief overview of synthetic compounds in study. 4:30 min/secs in
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As far as lutein, resveratrol and curcumin, seen in the screenshot of Bill Faloons presentation, none of these are likely to significantly ihibit IL-11 in humans in vivo upon ingestion of reasonable doses.
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A new video just uploaded to the ARDD YouTube channel from the most recent ARDD conference:
Inhibition of IL11 signalling extends mammalian healthspan and lifespan
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Faloon is a great salesman. He knows his audience well. The reference to resveratrol provides a connection to what his audience already believes in which makes the rest of his recommendations more believable. I’ve seen several of Faloons presentations…he and his guests make easy to implement recommendations (take a pill) that hang on very thin evidence. It’s not that they are flat out lying but the benefits are unlikely. They rely on a placebo effect I suppose for repeat business. An effect from any source is a fine thing as long as patients don’t get negative effects from being convinced not to address diseases with proven interventions. That’s my opinion of course.
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gerard
#157
Hello, have you started your trials with any anti-IL11? I’m very interested in the topic.
The problem may be that if you use too much rapamycin, you can tamp down MOT2, which you don’t want to do. So it might be that if you combine rapa with an IL-11 antibody, you might downregulate MTOR too much.
Until we can measure mTOR clinically, and then ideally know how it is impacted in different tissue types, this is unknowable.
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gerard
#160
Another effect that is rarely discussed is that by inhibiting IL-11, fibrosis in the organs can be reversed — in other words, it repairs damaged organs, greatly improving people’s quality of life.
https://www.nature.com/articles/s41467-022-35306-1
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Have you found anything that benefits your autoimmune disorders? I’m trialling rapamycin for this, and longevity.
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gerard
#162
On Reddit, I saw a biohacker who had managed to inhibit IL-11 in his body using two compounds from Chinese plants: ‘…we combined oral Schisandrin B and Osthole, and we were able to identify a much more noticeable impact on IL-11 levels over the 30 day period…’
The problem is that he has been missing for months. I’ve tried to get in touch with him, but he hasn’t responded.
I can share more information about him, but since he has a supplement store, I don’t want you to think I’m promoting his business.
If @RapAdmin gives permission, I’ll post his name and the reddit thread.
P.S.: I’m very interested because I have kidney damage with fibrosis. It seems that the only way to recover my kidneys is by inhibiting IL-11, as shown in the Nature study.
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Yes, it’s hard. We have no idea what the appropriate dose is. I’m taking a handful of supplements, including rapamycin, and we really don’t know how they all interact.
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Thanks for asking. sure please post the info. It’s always a little scary when biohackers go dark suddenly.
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What evidence is there that those plants have inhibited IL-11, other than the claims from the guy with the supplement store? I guess one can’t ask for more details, since the guy no longer responds. It seems like not much to get excited over. YMMV.
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