I don’t put much hope in supplements having a significant impact on IL-11, but I do in the anti-body therapies and potential small molecules that could ultimately be FDA approved.
New research in a top science journal, Nature, reveals that the inflammatory molecule IL-11 contributes to aging processes and that blocking IL-11 improves function and molecular measures of healthspan, and extends lifespan by up to 25%, in animal studies. I review the data and offer you a potential solution.
8 Likes
adssx
#126
I don’t know anything about IL-11 but I understand that it is an IL-6-type cytokine and this paper suggests that alpha-blockers (also called alpha-1 antagonists) such as terazosin and doxazosin “could suppress IL-6 production”: Alpha-1 adrenergic antagonists and the risk of hospitalization or death in non-hospitalized patients with COVID-19: A population-based study 2024
The paper looks serious; however, I can’t find other articles that confirm this assumption. Is it dubious?
3 Likes
Interleukin-11 (IL-11) is a pro-inflammatory cytokine.
Quercetin has the most comprehensive anti-inflammatory profile among the three compounds mentioned in the video.
As I have mentioned, anti-inflammation is a key preventative measure to slow down aging.
I might add that there are a multitude of anti-inflammatories. There is nothing to prove that sulforaphane, berberine, and quercitin are the only or best combo to inhibit interleukin-11.
10 Likes
Dr. Attia weighs in on IL-11.
Great article. His thoughts are that we need to find out if IL-11 is additive to Rapamycin or not. If it is, it could be a blockbuster. Therefore we need a Rapamycin + IL-11 inhibitor trial in mice.
ITP 2025 cohort?
Please ignore the wrong title on the article below. The link is correct, but the cancer title is not.
8 Likes
约瑟夫
#129
FWIW…
"Even though tocilizumab has been on the market since 2009 for treatment of rheumatologic diseases, access has remained a challenge. Roche kept the price of this drug very high in most countries, with price tags ranging from US$410 in Australia, $646 in India to $3,625 in the USA per dose of 600mg for COVID-19. The cost to manufacture tocilizumab is estimated to be as low as $40 per dose of 400mg, given that the manufacturing costs of monoclonal antibodies are often below $100 per gram when produced on a large-scale. Roche should agree to sell tocilizumab for COVID-19 at a much more affordable price than they currently do."
Above is from;
5 Likes
adssx
#130
The ITP usually first tests drugs separately before combining them.
@Krister_Kauppi : should we try tocilizumab in the WormBot?
6 Likes
That would be a very interesting study but I agree that it feels like they want to first test drugs separately before combining. They seem to have done one exception to that rule in this year because ITP will test the combination Rapamycin and Trametinib (source: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions).
I couldn’t find tocilizumab (or Tofidence, Tyenne, Actemra) in the mTOR inhibitor library that we will screen. I also checked the current library that Ora has on the website but could not find that compound there either. So my guess is that Ora needs to buy this compound from a library provider if we want to test it. It should not need to be a big cost. Do you contact Ora? I know Ben is on vacation two weeks from now because he is getting married so probably you will get the quickest response from Mitchell.
By the way, here is also one interesting comment that I wrote to one person who was interested about IL-11 inhibition study. I think it can be very interesting to dig deeper around that topic.
“It is a very interesting area and as I understand it, the study seems to show that IL-11 activity is greatest from our fat depots. This makes me think
-
What is it more specifically in the fat depots that increases IL-11 activity?
-
What strategies are there to reduce IL-11 activity so that it does not even begin? I mean what is the root cause of IL-11 and if we can understand that then we should be able to attack the root cause by inhibiting the symptoms by IL-11 inhibiting therapies. Perhaps the solution is to keep the fat percentage at a low level which is an interesting alternative to IL-11 inhibiting.”
7 Likes
adssx
#132
I’ll ask them. Before, which one is best:
?
1 Like
Alex
#133
Just a supplementary suggestion
3 Likes
LukeMV
#134
Good choice. Boswellia could be underrated.
2 Likes
Good question, it may be that they use medchemexpress as supplier but I may be wrong. Best to ask Mitchell where they it because they may have some collaboration with a certain supplier. I think its probably also best that they make the order of the of the compound and that the compound is sent directly to them.
1 Like
adssx
#136
They ask whatever American supplier you give them and then they order it themselves. I’ve already done it before. My question is: which version is best?
1 Like
Great to know! I have no experiences of the suppliers but I would probably have choosen medchemexpress because that is the supplier I have heard of before.
adssx
#138
I realize my question wasn’t clear: are the products in these two links really identical? Are they the “real” tocilizumab? (sometimes they are subtle differences between forms) Can they both be used in worms?
2 Likes
It’s interesting question but I feel this is a domain I don’t have knowledge about but the people on Ora must know. Please keep me updated around the knowledge around this because it is good to know for future experiments 
2 Likes
Short video by Lifespan.io
1 Like
Speculation, but maybe track hsCRP and IL-6 and make lifestyle changes as needed to make sure both are very low. Reasonable but not certain that IL-11 is good if both are chronically low. Keep in mind that IL-6 is transiently increased with exercise. Will start tracking IL-6. My hsCRP stays low, < 0.3 or < 0.2 depending on lab test. There are many other inflammation makers which can be checked too.
2 Likes
Here’s the paper on lutein - Chinese paper:
Quote:
“ Conclusions: Lutein has potential as a treatment for cardiac remodeling and heart failure via the suppression of IL-11 expression.”
2 Likes
