I took collagen for about three months and could literally feel nothing, no effects whatsoever. Obviously, that doesn’t mean it is not good for you in long run, but I am of the belief that aminos should be taken in different times and not together to get the most benefit. For some reason I feel very significant benefits if i take certain aminos by themselves, as opposed being taken together via collagen and protein as an example. i.e. carnosine immediate relief of muscle pain, tyrosine - mood elevation within hour or so, Arginine- huge dilation and sexual effect (like firmer bigger erection, though can’t take it because it activates cold sores virus), L-lysine kills cold sores in couple days etc…None of these benefits from taking collagen, so take it for what it is worth but that’s my story and I’m sticking to it.LOL

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I have spent a lot of money over the years on collagen with no noticeable effects measurable or subjective. IMO: Collagen supplements are highly overrated. If there are no measurable or subjective benefits, it’s off my list of supplements.

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Actually, i took it for three months and it absolutely ZERO effect so I stopped even though I still had about 1/3 left. I might still finish it off for the heck of it, but you can rest assured that I will NEVER buy it again (can’t to pay such a high price for it and feel nothing). As I said earlier, with some individual aminos, I’ve had huge success in addressing some of the ageing issues, but not from protein shakes and/or collagen (that are loaded with aminos).

Do you take glycine? It seems that glycine (and GlyNac) have a lot of support.

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Hi Joseph, please remind why are you using Citrate and Pantothenic acid.

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Here are some of the most famous people in this space and what they take:

I know…Joe Rogan?
What do they all take? Vitamin D3/K2 and Omega 3/fish oil.
Usually also a multivitamin and often magnesium.
Because, I’m trying to build/maintain muscle (I’m 70) I always take creatine and collagen which also increases protein intake as well as glycine (and I take NAC Ethyl Ester form to boost glutathione production).
After reading alot here, I stopped taking the RBS Lipo NMN and Resveratrol but can’t help but feel that I lost a certain energy spark. I’ll have to go back and forth a couple of times. Had a complete blood work up and will start Rapamycin soon.

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@macneu2299 Ive tagged @John_Hemming as it is his anti-aging protocol that I am trying to implement. He has written about it extensively on this forum. I am still ramping up my dosing so I do not believe I’m getting a benefit yet.

I take Pantothenic acid for LDL / apoB lowering. This was a recommendation from @desertshores. My apoB and LDL fell drastically while I was taking Pantothenic acid / vit b5. I was also newly taking rapamycin (bad for ldl) and reducing my rosuvastatin dosing to EOD (bad for ldl), so I feel confident Pantothenic acid was good for lowering my ldl/ apoB.

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Thanks for posting. I think Andrew’s stack is pretty good. I’d add carnosine and lysine and get rid of the multi, just take vitamins individually as needed. Most in the multi are useless in my opinion.

Everybody’s different. I look at a multivitamin as a cheap insurance policy. You might have a deficiency/a gap somewhere that you didn’t know about or even every now and then. I’ll look at carnosine and lysine - so many amino acids. And certainly at my age, I need to be sure and get enough protein as I don’t eat a lot of calories.

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I hear you, but as Kevin O’Leary would say I don’t feel the love lol when I was taking it. Actually it was my very first foray into supplements about 25 years ago. I felt nothing, and to me the amounts for some crucial ones are so small, while for some others I would not need/take. I did it for couple years and as a side effect nasty one, I think it made me gain weight much easier than usual. Stoped it about 20 years ago and went for bcomplex, vit,c and couple other individual ones. I have absolutely no intention to add it to my stack.

B complex is the one that I can feel but there are so many others that people talk about here…selenium, zinc, boron, molybdenum, etc. that I probably get in my diet but that changes so often, usually I eat well but sometimes I don’t. At least with a multivitamin I know I’m getting a base level. With all supplements it’s hard to know what the minimum dose is that makes a difference. Astaxanthin is a good example, the usual doses are well below the ITP, are they doing anything?

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Based on my past failures, I think it’s important to only change 1 thing at a time to see if the change did anything at all, and whether it was good or bad, or both.

Soft: “Feel”, clear headedness, physical energy, exercise performance, sleep, etc
Hard: blood markers, BP, RHR, weight, HRV, etc.

I’ve decided to try GG (@desertshores found it) to see if I can feel a reduction in the muscle aches I get from my statin after my weight training. I’ll also avoid other changes until after my next blood test. I’m fitting this into my 10 limit by recategorizing my nitrate supplement as food (it has the same amount of nitrate as 5 stalks of celery).

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The other thing is that I think it’s likely that most vitamins/supplements work in a synergistic way in combination with others, so that if you test one by itself you won’t get a positive result, they need to work together…GlyNac for example. It could be a reason that supplements fail the ITP when they show good results elsewhere. That’s why the concept of testing one supplement at a time (while useful) may not tell you the whole story…it might only work in combination with something else.

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This is anecdotal yet practical and based on my experience. The multi is useless, because for the most part our needs are taken care of with food but there is few vitamins/aminos that if take. By themselves in HIGHER doses can produce real great effects. I know there are recommended daily doses etc but that’s not the dose that will make e difference. As an example I’ve been 17 years flu,cold,sars, covid etc free because I do 2000-4000 vit c per day plus same lysine (when flu season). When I tried at 500 daily for each(trying to find the smallest but effective dose) literally started getting the flu within a week. Then upped the dose 2000x3 daily for both and my cold/flu or whatever the hell was just disappeared within 24 hours. So, many will tell you that even 500mg of vitC is too much, yet it did nothing to ward off the virus. Ever since I’ve been using 2000-3000 maintenance daily during flu season and have never gotten sick. So the moral of the story is you need much higher doses to get true measurable results. For wellbeing alone, probably a multivitamin is ok, but knowing what I know I will never add it to my stack.

Creatine
Taurine
Glycine
Melatonin
Lithium orotate
Multivitamin
Magnesium glycinate
Potassium citrate
Lactoferrin
Methylene blue
It was a stretch to come up with 10 tbh. I don’t take methylene blue or lactoferrin all the time and I tend to forget lithium quite often as well. I feel good though and I’m also taking Rapa and Deprenyl.

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Your energy spark probably came from the NMN. Resveratrol won’t give that to you.

@约瑟夫_拉维尔 what is your pantothenic acid dosing regimen?

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They both seem to have lots of sceptics here - maybe because of their association with David Sinclair, the great salesman. And pterostilbene may be better than resveratrol. But certainly a lot of people swear by some form of NAD precursor.

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Just keep an eye on your kidneys. There is mouse data showing NMN can damage kidneys of old mice. Your blood will tell you the truth.

As for Resveratrol, it always gives me diarrhea, so I am happy to stop when I use up all my supply. I think I have a year supply left. :stuck_out_tongue:

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@DeStrider i take 500 mg every morning (6 days a week).

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