#635

So did your Lp(a) change at all after starting the statin and Ezetimibe?

#636

I didn’t recheck on my latest blood test since I didn’t expect it to get better ( maybe slightly worse) and the test is a little expensive. I will retest it at some point, maybe after 3 months of rapamycin. I’m kinda resigned to just having high Lp(a) until a new drug comes out. PCSK9i would help some but probably not enough to make a real difference.

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#637

That makes sense. My Lp(a) was similarly high to yours when tested back in April. I have implemented 3g per day Niacin and 4g per day Omega 3 to see whether that helps after a year. I have also started high dose Natto (12,000 FU per day), Neprinol AFD (60,000 FU per day) and Lumbrokinase (40mg per day). I had already been taking 80mg Atorvastatin for several years so clearly that had little to no impact on my Lp(a). I just thought I’d try and throw everything at it for now to see whether I can get it down at all. My current plan is to stop the daily Lumbrokinase, Neprinol and Natto after 12 months and then just run a maintenance dose of them for one month every year. Obviously I will review the Niacin and Omega 3 in light of the 12 month test result.

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#638

Yes, I think the best thing is to keep the other risk factors low - so, low ApoB, low blood pressure, low inflammation (Hs-CRP) and low blood sugar/insulin resistance (HOMA-IR).
And I take 3g/day Omega3.

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#639

I am not a big fan of Omega 3 consumption, especially large doses.
It can have some of the following drawbacks:

Increased Risk of Atrial Fibrillation
“Omega-3 fatty acid supplementation may increase the risk of atrial fibrillation
This risk appears to be dose-dependent and more pronounced with higher doses”

Omega-3 supplements may increase the risk of bleeding.

Omega-3 supplements may increase the risk of stroke in patients with previous myocardial infarction.

Omega-3 supplements may interact with:
Blood thinners
Blood pressure medications
Diabetes medications

These are primarily dose-dependent. Just be careful.

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#640

See my post here:
https://spotify.localizer.co/t/if-you-could-only-take-10-supplements-a-day-what-would-they-be/11472/40?u=ng0rge

What do they all take? Vitamin D3/K2 and Omega 3/fish oil.
I think among people interested in longevity and cardiovascular health, Omega 3s are maybe THE most recommended supplement.
Here, a top cardiologist - William Cromwell - recommends them.

https://www.youtube.com/watch?v=gfzxnz1sdi0

And for Rhonda Patrick, it’s one of her top recommendations.
Dosage is up to individual needs but I would recommend the OmegaQuant test and keeping the basic level around 8-12%.

https://omegaquant.com/

Also this new video from Physionic, he does address the drawbacks right at the end.

https://www.youtube.com/watch?v=I5vnLWPeuAY

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#641

From my research, the problem was with Omega-3 daily dosing of 4 g or more. 1 gram was fine. I take 2 grams daily which should also be fine.

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#642

There are also neuroprotective and anti inflammatory benefits of DHA and other omegas to consider in your risk calculation.

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#643

Yes, I remember reading that study a few years ago where the increased risk of Atrial Fib was noted. IIRC it was a very small risk increase and completely reversed by lowering the dose again. I don’t really get any Omega 3 from my diet because I don’t eat fish which would probably be the best way to take it. I get plenty of ALAs though from flax and chia seeds. Thanks for the heads up though @desertshores

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#644

A small dose from Opti Omega-3 is healthy for the brain.

I take one capsule per day. It’s cheap.

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#645

You raise a really interesting point. This seems to be the best/latest meta analysis:
“Recent clinical trials suggest, but do not prove, a dose-related risk of AF with omega-3 fatty acid supplementation. Curfman [21] found that treatment with 4.0 g/day of omega-3 fatty acid was associated with an almost 2-fold increased risk of AF, whereas treatment with an intermediate dose of 1.8 g/day was not associated with an increased risk of AF”

But it seems that high dose omega 3 may be protective once you do have AFib… “Regular use of fish oil supplements might be a risk factor for atrial fibrillation and stroke among the general population but could be beneficial for progression of cardiovascular disease from atrial fibrillation to major adverse cardiovascular events, and from atrial fibrillation to death”

I seem to remember you don’t like fish, but i thought it would be interesting to see how this all translates into fish consumption:
“The lowest risk of AF was found in those who consumed around 0.63 g marine n-3 PUFA per day, which corresponds to around two servings of fatty (oily) fish per week (1).
Earlier studies have reported that regular consumption of fish can exert beneficial effects in preventing the development of AF”

U-shaped curve revealed for association between fish consumption and atrial fibrillation.

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#646

To be sure, yes, I do take an Omega-3 fish oil supplement.
The Omega-3 supplements have a long half-life and effect.
I take one gram every other day.

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#647

Thanks @AnUser - that really is a great price for algae based Omega 3. I found youtheory vegan softgels in Costco USA at a great price but unfortunately Costco UK doesn’t stock them.

1 Like
#648

Are microplastic particles taking a toll on your health? Researchers share steps to lower your risk

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#649

This is the one Bryan Jonson’s team vetted and that he uses?

They are now delivering in the US.

Does anyone know how their cold chain is?

#650

It just says store in a cool, dry place, on the bottle.

#651

Yeah, more asking about the logistics of getting the product to us cold…. Once it is in my hands i can take care of it well.

I ordered some from the UK before they had a US offering and it got stuck in shipping/customs or something and I did not feel good about that delay given the importance to keep omegas cold/cool.

#652

I’ve never noticed these ones go rancid, but I’m unsure what it would smell or taste like.

we have extensively stability tested our Omega-3 products to ensure they stand-up to elevated (and low) temperature climates. The most important factor is to ensure that once opened, they are stored in a cool, dry location. In the case of the Omega-3 Liquid, we recommend storage in the Refrigerator to prolong freshness.

There are three different antioxidants in it so that helps.

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#653

It probably requires a higher dose than 1 capsule though, but for now I am only taking one capsule as I learn more. I think Bryan takes 4 capsules. 2 capsules was the same as that other trial. Healthy vegans according to Joel Fuhrman live longer and as a result of that get parkinson’s disease and dementia, so protecting the brain is important. He thinks low algae oil intake can result in this (dha/epa).

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#654

Lipids and CVD risk. I’ve been reading with interest the above posts, I’ve been into this topic for 2 reasons mainly.

  1. I’ve yet to decide whether to follow Peter Attia’s scheme to lower ApoB to the very first percentiles of the population. By use of pharmaceutical drugs. My lipids are pretty good, but he makes a good point that sweeping CV risk off the table may give us more time to think about other risks. We also know that the scheme is relevant to a 10 to 30 years period. But we all want to keep atherosclerosis away until a late death, I think.
    2.My wife has pretty high lipids values, and from her experience I recognized that the optimum treatment is strictly individual. As Tom Daysprings makes clear, statins inhibit systemic synthesis of cholesterol, ezetimibe inhibits gut absorption, bempedolic acid inhibits liver synthesis mainly. So, the adoption of one or a combination of both depends on individual variations. In the case of my wife, 5 mg of crestor abated ApoB/cholesterol about 40%, exactly as Dayspring says and as literature predicts. But her liver enzymes got a little high, so her GP prescribed her ezetimibe instead. This only reduced cholesterol of 8%. She’s evidently an over-synthetizer, rather than an over-absorber. I don’t know what the GP is going to suggest to her next. Probably bempedolic acid, which has a smaller predicted effect, or maybe ezetimibe+bempedolic, which together may reach a reasonable effect.

Back to my first item, I still am undecided about the optimum strategy. If I am now at the 5th percentile, is it useful to go lower and take a drug or the possible collateral effects of such drug may overcome the benefits. Not a simple choice for a person with a low risk appetite.

I wonder about your thoughts.

1 Like