The best counter-proof to ratios being an useless metric would be apoA-increasing medication failing in the initial clinical trials.
lin
#42
I apologize for the misquote, was typing on my phone during lunch.
Do you mind linking the tweets from these experts? I ask because it would be relevant to the topic of this thread.
My source was linked in my original comment, it is the same source for the graph I attached.
lin
#43
The CAC guidelines are a relatively recent phenomenon that may not have been put in practice during your visits. I hear it mentioned occasionally in the longevity field (Coronary artery calcium scan - Peter Attia)
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Having been on the path of trying to reduce LDL for the last three-plus years I would reiterate some of the points already made as this is what worked for me.
- Get a CAC scan. It’s cheap and will at least give you a good idea of whether you already have damage or not. If the score is >0 then proceed with the following steps.
- Start a statin and titrate up slowly to the maximum dose you can take without side effects. Be extra vigilant with testing since you only have one kidney.
- Add Ezetimibe 10mg which will lower LDL further than a statin alone.
- Add low dose Colchicine 0.5mg to reduce inflammation caused by the existing plaques.
- If you have high triglycerides then add 3g of Omega 3.
I have done all the above and my non-HDL is down from 6.7 to 1.3mmol/L (sorry, UK units) and triglycerides down from 2.3 to 1.4. Good luck.
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What are the side effects of Rosuvastatin? Ever since I started taking it, it seems like my muscles are a bit sorer than before. This side effect seems to be getting better with time, but man the first few days after starting, I felt old. I did start taking ubiquinol (CoQ10) after a couple of days and that seemed to help. I have read you should be taking CoQ10 along with a statin.
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Yeah, muscle aches are definitely a problem. I’ve learned to put up with it but ideally I would like to reduce my statin dose in the longer term if I can keep the LDL muted enough. I only introduced the Ezetimibe in March of this year so if the lipid panels stay good then I will experiment with statin doses. I’m currently on 80mg Atorvastatin (the maximum). I also take 200mcg of selenium and 200mg CoQ10 and I would say that probably does help a little. However it’s hard to know whether it’s just because I am getting more used to the muscle aches. I have no experience with any other statins. In the UK Atorvastatin is the first choice and it’s difficult to get anything else prescribed to my knowledge.
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I switched to every other day dosing (at 2x) of rosuvastatin to stop the muscle aches. It works. I don’t take it on my lifting days. Atorvastatin was worse. Worth a try before giving up.
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@约瑟夫_拉维尔 What was the difference in LDL levels between the 2 different dosing methods? Did you check?
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I haven’t gotten a new apob (healthspan doesn’t offer it) but my non-HDL decreased from 84 to 59, and LDL decreased from 71 to 44. This coincided with the addition of rapa but no change in diet. My TG increased from 63 to 70. I wouldn’t conclude that this was all due to the change in rosu dosing but the change certainty wasn’t negative.
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curt504
#51
Hi Eric, I’m not a Dr, there are many Drs and top folks here. Just my views; But first; My wife and I have a hobby of going to medical conferences; Metabolic Health (AKA low carb) (Boca FL, and Denver), MHS another Metabolic conf last one was in Santa Barbara. I can “parrot” your 175ish LDL is to be desired, even low. My own 200 IMHO is great. Lower mortality, much lower covid19. Cardio vascular disease (per the speakers) doesn’t track LDL but Apo-B in the presence of calcifying arteries.
The one relayable comment: Get a calcium scan. Your worry and action should be determined by y9our calcium score. Start tracking Apo-B… There’s a thread here on calcium scan. A low calcium scan even negates a higher Apo-B (per the speakers).
Just giving my quest; LDL 200-250ish through the rest of my life. My calcium score is zero in all areas. We are carnivor just had 1/2# of grass fed burger each for dinner.
In todays pathogen rich environment I feel a high LDL is a good thing.
Just my views.
Best to all, curt
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AnUser
#54
200 is Hypercholesterolemia.
You must’ve misunderstood something from those conferences. Maybe they were talking about total cholesterol.
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I just listened to a Greg Fahy interview from last year in which he said besides taking his own TRIM protocol, he also takes centophenoxine and carnosine. He said the carnosine was specifically to prevent/reduce aging for his muscles, and his muscles don’t show signs of aging because of the carnosine — he was very adamant (in a positive way) about it. He did not mention beta-alanine for his muscles. Any thoughts here?
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