#185

Just sharing what I came across in Apple News…

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#186

Healthspan launched a veterinary platform to provide pets rapamycin that is available in CA and NY.

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#187

“Pharmaceutical-grade medications with highest bioavailability, fulfilled by a US-based LegitScript certified pharmacy.”

I hope this doesn’t mean it’s compounded rapamycin capsules, which are likely essentially useless given the poor absorption.

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#188

Someone needs to double check this with healthspan.

#189

I can’t see a way to even ask them a question without signing up and giving them my email and contact info.

#190

@Daniel_Tawfik , we see that Healthspan has now launched a new service for dog owners, providing rapamycin. This is great news and should make it much easier for people to get rapamycin for their dogs.

We have seen some problems with compounded rapamycin in the past - can you please confirm that you guys have looked and solved (or avoided) the bioavailability issue with this new dog-oriented product (as well as the human oriented rapamycin)?

See: The bioavailability of compounded and generic rapamycin in normative aging

#191

Hi @Davin8r and @RapAdmin. Thanks for your question. To clarify, we do not prescribe compounded rapamycin for either Healthspan or Petspan.

The main reason is that compounded rapamycin, typically in regular capsules, would not effectively pass through the intestinal lining due to its acidity. This can severely limit its absorption, making it less effective.

The generic rapamycin we prescribe is selected for its bioavailability. Both manufacturers we work with produce sealed-coated tablets, which are the same type of medication used by transplant patients, including my wife, Dr. Miller, who relied on generic rapamycin (specifically from Zydus and Glenmark) to manage her stem cell transplant graft-vs-host condition.

We’ve also verified the bioavailability of these brands in humans through Sirolimus panels offered to Healthspan patients as part of our protocol. The brands we prescribe demonstrated the highest bioavailability among available options, comparable to Rapamune in both cmax and tmax.

While compounded rapamycin might offer cost savings, its poor absorption makes it a suboptimal choice, which is why we don’t prescribe it.

We have quantified these bioavailability findings through our testing at Healthspan, and we are committed to providing the same level of quality to Petspan patients.

@Davin8r if you want to ask any other questions over email you can email me directly daniel@mypetspan.com or daniel@gethealthspan.com. Our team is also available at support@mypetspan.com and would be happy to assist.

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#192

Excellent, thanks Daniel!!

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#193

People may be able to use this evaluation to judge the effectiveness of rapamycin use by their dogs. Do a pre-treatment assessment, and a post treatment assessment (6 months later) - and please report back. The assessment is at the bottom of this post, as well as the scoring template.

New tool can assess elderly dogs’ frailty

Researchers from North Carolina State University have developed a tool that can aid owners and veterinarians in assessing an elderly dog’s frailty. The tool—when coupled with simple assessments of body and muscle condition by the veterinarian—can predict likelihood of short-term (within six months) mortality and provide important data to owners faced with treatment and quality-of-life decisions for their aging dogs.

"One of the most common questions veterinarians receive from owners trying to decide on treatments for elderly dogs is, “How long will my dog live?'” Olby says. “If we could develop a phenotype that is reasonably predictive of short-term mortality, it could be helpful for owners who are faced with treatment decisions.”

Research Paper (open access):

Establishing a clinically applicable frailty phenotype screening tool for aging dogs

Conclusion: Based on these findings, the defined frailty phenotype represents a valuable screening tool for early risk identification and intervention, and can aid in clinical decision making for owners and veterinarians. Additionally, it will promote further research into the understanding and treatment of frailty in dogs.

Data Sheet 1_Establishing a clinically applicable frailty phenotype screening tool for aging dogs.pdf (493.4 KB)

DogFrailtyScoringTemplate.pdf (51.9 KB)

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#194

It looks like Healthspan has now expanded into pet care, with rapamcyin for pets. This should make it easier or people to get rapamycin for their pets:

#195

Curious how many people’s dogs know the term “rapamycin” :slightly_smiling_face:
Mine does, she comes running when I say it but it may be the Gouda cheese I put it in.

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#196

Interesting new paper from the Dog Aging Study

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#198

turingbacktheyears.com provides rapa at the best price on the internet. top quality along with links to the science and other positive new products to help with anti aging for pets and people . our prices cant be beat :slight_smile: please check us out , we are committed to this space . quick delivery and guaranteed

#200

IMO you should wait for a year or two before it reaches full maturity.

#201

You misspelled your link

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#202

Thank you for answering these important questions and offering this for our beloved animal companions.

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#203

My 7 year old Standard Poodle Ian has been taking rapamycin since May of this year. He has been taking 4 mg of rapamycin (Zydus) weekly and there has been no negative side effects whatsoever. His annual blood work was great. I haven’t noticed any changes, good or bad. And I intent to continue to give it to him. I purchased the Zydus rapamycin from India and has been very happy with the quality.

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#204

Another question, what is the protocol you are using? Three times a week or just once a week?

#205

Hi Angel, Petspan’s protocol is once a week. The idea would be to allow an mTORC2 rebound. Let me know if you have any additional questions.

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#206
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