#82

Hey, that’s not funny! (jk)
Maybe because my background is Irish and the Irish love to drink and argue (fight) for recreation, I kinda like watching from the sidelines (See the movie “The Quiet Man”). I keep saying “Hit 'em again!” But also I keep switching sides. It may be just men and their testosterone - and you know how hard we work at keeping that up - but I don’t take it as real aggression. It just occurred to me, about the Irish, that drinking and fighting may well explain @JuanDaw chart above about the French Paradox.
P.S. No I’m not drinking (at the moment).

4 Likes
#83

You both remind me of my grandson who is on the autism spectrum.
He frequently offends without meaning to.
An example (paraphrased):
Autistic person: “That is a very ugly blouse you are wearing.”
Other person: “That was a very rude thing to say! Why would you even say that?”
Autistic person: “Well, I would want someone to tell me if I was wearing something ugly.”

10 Likes
#84

Sorry. Forgot to check that angle. But it seems, the French drink more than the Irish.

https://www.cia.gov/the-world-factbook/field/alcohol-consumption-per-capita/country-comparison/

Rank Country liters of pure alcohol Date of Information
1 Cook Islands 12.97 2019 est.
2 Latvia 12.9 2019 est.
3 Czechia 12.73 2019 est.
4 Lithuania 11.93 2019 est.
5 Austria 11.9 2019 est.
6 Antigua and Barbuda 11.88 2019 est.
7 Estonia 11.65 2019 est.
8 France 11.44 2019 est.
9 Bulgaria 11.18 2019 est.
10 Slovenia 11.05 2019 est.
11 Luxembourg 11 2019 est.
12 Andorra 10.99 2019 est.
13 Poland 10.96 2019 est.
14 Romania 10.96 2019 est.
15 Ireland 10.91 2019 est.

We have a thread here about Viagra and reduction of Alzheimer’s risk. Maybe we can ask people from Ringaskiddy.

4 Likes
#85

What?!!! Them’s fightin’ words. Nobody drinks more than the Irish - except the Russians.

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#86

Make love not war. Live in Ringaskiddy.

I stand corrected.

https://www.drinkaware.ie/research/alcohol-consumption-in-ireland/?a=adult-per-capita-alcohol-consumption-in-ireland

ADULT PER CAPITA ALCOHOL CONSUMPTION IN IRELAND

The most recent data (2019) available shows that in Ireland, total per capita (15+) alcohol consumption in litres of pure alcohol is 12.75 litres. This includes both recorded and unrecorded per capita consumption from 2016-2018, which together provides a more accurate estimate of the level of alcohol use in a country and as a result, illustrates trends in alcohol consumption in a more precise way.

Maybe the CIA did not know about the drinking on the sly (from the wife).

3 Likes
#87

Once people run out of arguments, they start arguing about tone.

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#88

I see the same thing from Thomas Dayspring and he is 77 years young.
I would say it has to do with knowledge and will.

It’s easy to adopt the behaviors of those who taught you.
I can’t think of a cardiologist or evidence-based longevity doctor who isn’t assertive with their arguing. But I would happy to check them out provided they are not a quack.

It looks to me that very few people understand this topic, despite numerous debates and back-and-forths. Why this topic especially? I don’t know.

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#89

I love any link to the New York Post ( a rarity here), always good for a laugh, (who needs The Onion?) and I would say this is the relevant quote:

“I wouldn’t say that’s how we are exactly,” Sadie told the paper. “We’re just happy.”

#90

Did I say “assertive”? I believe the word I used was “obnoxious,” for which the former would be a very charitable stretch at a synonym.

As far as indicators of youthfulness in men in their 20s go, the most robust would be a conspicuous absence from online forums with a 1 to 1 substitution of every minute spent here with having a life out there, going out with friends, getting laid—not fixating on death prevention but living life. Hypochondria is an independent risk factor for early death don’t you know, so preoccupation with one’s untimely demise could paradoxically be contributing to it.

@AnUser I have not run out of arguments—had none to begin with. I don’t have a position on the cholesterol debate and am comfortable knowing that I simply don’t know. The arrogance of those convinced they do is astounding when you stop and think for a moment that we don’t understand what causes even a hair follicle to lose its melanin with age or how to reverse the process. But you think you can completely halt heart disease by simply taking enough of a statin starting early enough in life? A bit of epistemological modesty on all sides would go a long way here.

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#91

Hit 'em again! I’m on your side.

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#92

Why do you think that? In the presence of oxidation and an inflammation why would ASCVD never be able to develop? (Assuming anyone could live that long)

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#93

I think a poor immune system will kill anyone before 200 regardless of their LDL number.

After reading about GDF11, it now seems like living longer is overcoming sets of hurdles. High TC, ApoB, and LDL is the first hurdle known as arteriosclerosis. Another hurdle is HBA1C called diabetes. One of the final hurdles is a poor immune system that allows pneumonia or the flu to kill you. You could say the same about sarcopenia and cognitive decline. If you fail to clear a hurdle, you’re out of the race.

Rapamycin seems to place all the hurdles further down the track. :slight_smile:

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#94

For someone not endorsing a view you sure are spending a lot of time and effort trying to find data to support it.

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#95

Because while apoB particles can enter the blood vessel walls, the body has the ability to remove them to some extent. We’ve seen it happen repeatedly in both animal and human trials.

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#96

Yes but the ability to remove them may not exceed the rate of apob penetration. Do we know what influences the rate of removal? (Immune function, mitochondrial health, age?)

And the rate of penetration seems to be based on not only the number of apob particles but also other factors, such oxidation levels and inflammation. So perhaps person A with apob 40, and a high level of oxidation could be more at risk of atherosclerosis than person B with apob 80 but an oxldl a third that of person A? OxLDL rates can vary enormously.

Does that fit with your understanding?

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#97

The higher other risk factors the lower you own apoB must get in order to avoid plaque development. Still, with an LDL-C of 20-40 it is exceedingly difficult to develop plaque unless your body is completely breaking down most of its vital functions in which case you would still not die of from cardiovascular causes.

#98

Where did you pick up that?

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#99

I played around with numbers as I am waiting for friend to come around. JUPITER shows p=0.76 CI 0.95 -0.25% to 0.11% for reduction in CV mortality in rosuvastatin intervention group.
No statistical significance whatsoever.

#100

It think plaque formation is mostly attenuated by efficiency of reverse cholesterol transport. Some people just have more efficient apoA-1. Efficient reverse transport can avoid plaque formation even with familial hypercholesterolemia. The more efficient reveres transport the less chance of ASCVD. The only problem is that there is no way to easily measure this and there is no intervention known that would ameliorate this. In theory that means that you can get ASCVD at LDL-C of 40 and not get it at 200+.

#101

Huh? I was talking about your claim of increase in fatal MI and that you didn’t say the p-value for that.

1 Like