I have been tracking my blood glucose and shifted to 16 mg/ fortnight so the impact was less frequent.
Took bloods 2 hours after taking Rapa without GFJ and without my usual fat quota.
Trying to calibrate - this seems very high, since last time on 12 mg I only registered 11mcG/L.
Anyone else had such variability?
I normally have my rapa with a butter coffee - so wondering if this is what caused the difference since I think the fat flattens out the top and lengthens out the effect?
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What time of day did you take the rapamycin in each case? Any other meals or food in the hours prior to dosing?
Both about 2 hrs before collection.
The most recent sample, I didnāt take fat with it - but didnāt have breakfast in either case.
Thinking I will go and get another blood test at 2 weeks to see how the body has gone getting rid of it. Maybe it has been building up on a 16mg/ 2 week doseā¦
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Thatās a huge variance. The fat might explain 30% of the variance but the restā¦ I canāt explain. If you were even 15 minutes off the 2 hour target that might explain it. Catching the peak sirolimus levels is like catching a falling knife, very difficult and rapid variations.
The trough is more important. Check levels just before next dose.
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yeah - could easily be 15 minutes difference - so perhaps that plus the fat, plus it was a 33% increased dosageā¦still surprising that produced 4x.
Seems I caught that falling knife on the second, sample, ;$.
Agree - Iāll check I am back under 2 before I take my next dose - thx for your feedback
So it seems my trough level is fine. Took a 2 week holiday just to make sure while waiting for results, just to be sure.
Might drop back to 12mg/ fortnight and take it with fat to blunt the spike - is my conclusion. Besides the lab rang me up in a slight panic asking if I wanted to chat to a doctor on the first sample 
Anyone else done multiple peaks/ troughs in blood levels?
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I keep telling people to test rapamycin at 24 or 48 hours after dosing. Itās mostly useless to test your levels a few hours after dosing. There are so many factors that influence when you experience the exact peak and how high it is so there will be a wide variation in your levels a few hours after dosing. Your results are not strange and prove my point of how much better it is to test blood levels long after the peak is over.
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