#246

has anyone tried natto?
I saw a really scary increase in BP last week… It’s usually 100/70 but I saw it as high as 131/92 a few days ago… and 126/78 today. I did take some rapamycin with ketacon* like 1.5 weeks ago or smg and I guess I have to monitor something I’m not used to monitoring
at A4M last december i was tested low on NO. I should be getting more garlic and ginger [small amounts each time] though they aren’t easy to eat in bulk

doesn’t seem “whole enough” but might still be worth trying

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Rev. Cardiovasc. Med. 2023; 24(8): 234 Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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I saw a scary increase before in January 2022 - this was after a lot of nut binges, and it did go down the month after…

#247

Over what period are you measuring BP. It can take a bit of time to settle down.

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#248

I take that nattokinase, plus add another 2000fu to it. I don’t think it affects BP. I would say to take citrulline, eat lots of celery and avoid mouthwash. @约瑟夫_拉维尔 had a couple episodes on this I think, and NO is a big deal.

#249

Arginine too? Bitter melons? SOME cucumbers?
I exhausted my arginine supplement last month, evidently it didn’t really help…

#250

Citrulline is more effective than arginine. It helps with NO production and blood flow.

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#251

Some good information by @Ziegelhausen about how to purchase and use the Aktiia continuous blood pressure monitor from outside Europe. I think I might want to get one of these this year (and before they start selling officially in the USA).

4 Likes
#252

Blood pressure change after beginning taking 5 mg Rapamycin pr. week (just as RapAdmin I had a slow ramp up). There’s no real blood pressure effect on me.
I went from a monthly average of 142/92 to 137/92 (my blood presure has been too high for two years, now daily taking 100 mg Losartan Medical Valley for it, BMI 26,0)

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#253

Hi! Did you start back up on the rapa? I have high bp also.

#254

Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat

https://journals.physiology.org/doi/full/10.1152/ajprenal.00379.2007?utm_source=chatgpt.com

This is a low dose rapa article. Favorable. Chat at the consumer level just looks at the cancer and organ transplant cases with high rapa doses and make generalizations.
You have to specify low dose to get accurate research articles.

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#255

Sorry - I wasn’t too precise (my fault)
Last summer my blood pressure was 142/92 (with the prescribed 100 mg Losartan, daily). Then I began Rapamycin 5 mg pr. week. Now 6 month later my blood pressure is 137/92 (with the prescribed 100 mg Losartan and 5 mg Rapamycin).

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#256

That’s good to see it has gone down some in your systolic number! Those are still relatively high numbers though… Does your cardiologist know you are taking rapa? Curious to what their thoughts are.
Do you have known CAD? Do you check your glucose levels too?
Thanks! Cheers to health!!

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#257

A doctor (EU Doctor) started my Rapamycin medicine cure. I did inform her about the blood pressure medicine. Over 3 month I got 3 Rapamycin prescriptions (covering half a year).
No CAD’s - all good numbers (checked every 6 months by my GP). Glycose 6,1 mmol. My cholesterol however, is too high, LDL 4,3 mmol/l (which is a pre-rapamune condition I have to work on)
I haven’t told my GP about my “dietary supplement”.
Cheers :slight_smile:

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#258

Is that a fasting glucose?

#259

yeah, fasting. I believe the normal band is 4-6 mmol/L (where as the non-fasting limit is 8 mmol/L). Cheers :slight_smile:

#260

For fasting it is in the pre-diabetic range. It is probably worth getting HbA1c done and maybe running a CGM for a week to see what is happening.

Different people have different ranges

  • Fasting blood sugar test. A blood sample will be taken after you haven’t eaten anything the night before (fast). A fasting blood sugar level less than 100 mg/dL (5.6 mmol/L) is normal. A fasting blood sugar level from 100 to 125 mg/dL (5.6 to 6.9 mmol/L) is considered prediabetes. If it’s 126 mg/dL (7 mmol/L) or higher on two separate tests, you have diabetes.
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#261

https://www.reddit.com/r/Rapamycin/s/AahcNm0QLS

#262

It’s tricky to get an accurate fasting glucose reading in a lab. It changes every minute. I wear a monitor and it would show 70 mg/dl at 6 am, then 80 when I get up at 7:30 am, at the time when I reach the lab by 9 am, it’s already 100+. My point is that without a monitor it’s almost impossible to know your accurate fasting reading.

#263

That’s an interesting point. I have not myself worn a CGM when fasting. Obviously glucose will vary, but not as much as when not fasting (or I would assume so). I have in fact implanted a CGM this morning to monitor the effects of an intervention I am planning for Saturday. It would be quite a good idea to track glucose with a CGM when fasting to get an idea of the variations.

#264

BP also varies a lot from minute to minute. Have you tried tracking it every minute for a while to see what happens?

#265

FWIW, my blood glucose varies more from dawn effect, exercise, etc than food. It’s easier to pinpoint when (and often what kind) of exercise I’m doing in my CGM graph than it is to see where the meals occurred.