#142

Hyperbole is its own reward.

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#143

Maybe it’s E5. Just going by the way he talked about it. And if I remember right he’s now working with Harold.

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#144

The are three statements in the interview that make it seem it may not be E5: (1) Dr. Fahy says it’s a material he identified. If he had been handed E5, would he have said he identified it? Sounds like he’s saying he came up with it himself. (2) He says the first trial group consisted of himself and his CEO. Although he’s working with them, Harold Katcher isn’t the company’s CEO and has indicated on occasion that he intends to try it on himself. Dr. Katcher is about 80, so he probably wouldn’t be waiting around for the two younger guys to check it out before he rejuvenates himself. (3) He says it’s a mystery how it works. I think E5 was supposed to work by the young factors from the plasma signalling old cells that they were in a young environment, causing them to become more youthful. If that’s really how it works, it’s not a complete mystery - granted, even with an identifiable mechanism, actions at that level are mysterious. But maybe they found that that’s not how E5 works and what was thought not to be a mystery, has now become a mystery.

In common with statements that have been made about E5, he says they are refining it to get at the material/factor that is responsible for rejuvenation.

Parsing his words may not be the best way to get a clue. Like the lady interviewing him, I’m looking forward to more info.

1 Like
#145

I agree and either 1) or 2) would be enough. Nice.

#146

Agent Smith, I wonder (I do that a lot … “wonder” that is) if it would work to use ibutamoren mesylate in place of HGH to get Thymus regrowth and Canagliflozin in place of DHEA + Metformin to control the resulting rise in insulin and blood glucose levels in order to simulate the Fahy Protocol. Of course, this does not account for the new substance Fahy may add to the latest protocol that he says reverses age by 6 years in 90 days whether that new agent be E5, Gallic acid, or whatever, but it would probably cost a lot less than $15,000 per year. It’s an off the wall thought filled with potential pitfalls whereas paying for the latest TRIMx (a,b,c,d,etc.) would be the safe route. But, if the proper doses could be determined does it seem logical?

5 Likes
#147

The thing about MK-677 is that it causes a lot of water retention, increases appetite (why bodybuilders sometimes use it), and can increase prolactin in addition to the reduction in insulin sensitivity and IGF-1 increase. I only tried it once, though I did a high dose to check the potency while waiting for HPLC results, and I woke up in the middle of the night starving. I’d keep cabergoline on hand and would monitor prolactin.

Now the nice thing about it is that they say you get pulsatile GH secretion as you would naturally, though I don’t know if that’s true. It’s what I’ve read (maybe someone more knowledgeable can comment).

I think if I attempt to mimic the protocol, I’ll just source Chinese rHGH from reliable vendors. At low doses, it’s fine. You can find pharma HGH pretty easily on the underground but it’s more expensive (not thousands, but still hundreds).

The other route, of course, are the GH peptides others have mentioned.

I had similar thoughts about an SGLT2i and/or tirzepatide, but I’m just a layperson with no expertise so would end up experimenting and doing labs. I already take DHEA and pregnenolone. I was taking dapagliflozin, 5mg, but stopped until I understand more about drug/supplement interactions (lithium, for example) and muscle impacts.

The other thing I have thought about is adding some thymalin peptide and maybe thymogen to the TRIIM protocol.

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#148

Agent Smith, Thanks for the information. The MK-677 problems make it something I will avoid. However, the other things you mention are things I’ll investigate, assuming I want to imitate TRIIM, and I’m not sure that I do. But, the potential gains in muscle, bone, energy levels and thymus are attractive even though contrary to what I’m trying to do with Rapamycin. And, of course, how rapidly would I lose those gains if I were to do the protocol for a year? Would I want to just keep following the protocol? It is a conundrum.

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#149

I completely agree with this. Trying to source underground reliable HGH is the way to go instead of MK677.

I’ve personally have been doing my own TRIIM but with Acarbose instead of Metformin

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#150

LVareilles, Tell us more if you don’t mind. What’s the protocol and how long have you been on it? Do you notice any benefits or undesirable side-effects at this point?

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#151

I take 2iu of HGH before bed every night and have been consistently for a few years. I get slightly more intracellular water retention, so my arms look veinier and fat loss is slightly increased, so I have more room for error if I over-eat. I don’t notice any changes on any of my blood tests, or any changes in blood pressure.

4 Likes
#152

Just released

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#153

Interesting. He thinks rapamycin is bad for the thymus though but then… that it might be useful. Basically nobody knows it seems.

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#154

It probably depends on the rapamycin trough. If it is too high then it prevents the generation of new cells.

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#155

When Matt asked questions about that statement, it became a little more clear that Greg wasn’t talking about the 6mg once weekly dose that humans use. It looks like Greg wasn’t too aware how humans are using it and applied a higher dose daily use study to what he said.

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#156

A bit later he said the effect is temporary. So I got the rapamycin back out of the wastebasket.

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#157

This looks really interesting. Do you have any updates or insights?

#158

In case anyone is interested in TRIIM. This is the protocol:
“During the first week of the trial, rhGH alone (0.015 mg/kg) was administered to obtain an initial insulin response, and during the second week, rhGH was combined with 50 mg DHEA to evaluate insulin suppression by DHEA alone. During the third week, the same doses of rhGH and DHEA were combined with 500 mg metformin. Beginning at the fourth week, all doses were individualized based on each volunteer’s particular responses.”

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#159

I typically get an annual blood panel done every Jan (I’m behind with this one, should have it done next week) but I had an smaller interim test done in Dec (hormones). There has been a slight improvement in the immune markers.

I find that I don’t get “sick” the past year like I would normally get a couple colds this time of year but none so far. Would often get something from visiting our grandkids as their immune systems are learning to deal with all the stuff that goes around schools.

Same for my wife and 1 son who is on the same program, they have not had anything in the past 12 months. This son is a 41y/o gym rat who used to pick up colds from the gym but nothing in the past year. He goes 1 to 2 times a day 5 days a week to a very busy gym.

He just noticed last week that he has not had any issues the past year.

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#160

Thanks for the update. Looking fwd to hearing more.
Matt Kaeberlain is considering this protocol, so Im very keen to investigate.

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#161

Anybody been measuring CD4, CD8 or thymus volume before and after growth hormone (or similar)?

It would be cool to compare results and explore if a different intervention works better for thymus regeneration (i.e peptides)

2 Likes