Greg Fahy: We may have discussed what this guy is doing but can we talk more about him

[SNK]

@Ericross2

(or NMN for that matter)

Ouch, I do take NMN daily. Are you telling me that I’m risking cancer?
BTW never hear Fahy say he takes HGH? but you could be right…

[LukeMV]

Yes he is participating in his own trial so he takes it. He discusses it in the video I linked.

[Steve_Combi]

Kind of doing my own “version” of TRIIM.

GHRH - instead of somatropin - I’m more comfortable with growth hormone releasing hormones telling my hypothalamus and pituitary to make my own GH at the right time, while I sleep.
GLP1-R + GIP - instead of Metformin - for glycemic control, which is a problem with HGH and the stated reason to use Met in the TRIIM trials. But Met may be contributing in some other way.
DHEA - 75mg at night

Since the primary objective of TRIIM is thymus regeneration and reversion of immunosenescence, I’ll be looking to see if our markers related to that continue to improve with our next Trudiagnostic tests.

They are pretty good at the last test (Feb 2024), which was about 8 months after we started this program. Extrinsic age of 41 vs Bio age of 68, a significant 16 year improvement from 57. We started this experiment July of 23. So a huge drop in just 8 months.

In the same time frame and on the same program, my wife’s E-age dropped from 58 to 35!! at her then bio-age of 66. She beats me in all the tests

I’ve not seen any change in my hair colour nor any improvement in shrinking my forehead, it just keeps slowly getting bigger LoL!

Normal Physiology of Growth Hormone in Adults

[Jjazz]

This is great. Can you please share more on dosing/timing and formulations for each of these drugs?

[Ericross2]

I have been warned by several knowable people on this forum (albeit not this specific thread) that NMN promotes cancer. I don’t have the backing for these claim, but if I remember they were well supported. Their advice was for people who have had cancer before — or have cancer currently — it might not be worth the risk.

I’ll probably try the Grail test at some point, but for now, the risk might not be worth it.

Di you feel the NMN makes a significant change, as I see Tony Robbins touting that his “Navy SEAL commander buddy” told him there was a 30% increase in strength, endurance, mental acuity, and charisma.

[hamtaro]

I actually discussed Dr. Fahy’s youthful look with him, and he said he did NOT get any gray reversal from the treatment, but he said that his skin may have benefited from it. This wouldn’t be that surprising, since HGH sometimes has this effect on older individuals.

[SNK]

@Ericross2

Do you feel the NMN makes a significant change, as I see Tony Robbins touting that his “Navy SEAL commander buddy” told him there was a 30% increase in strength, endurance, mental acuity, and charisma.

I find it hard to measure or quantify effects of supplements, but some of them I do feel specific effects. As for NMN I think it is useful and helpful in overall wellbeing, and I tend to think (this may not necessarily be true due to the fact I take many other supplements) that NMN is good for joint health and helps with agility, can’t say anything about strength. to be fair I seem to have this same feeling about other forms of b3 also, so maybe I should switch to Niacinamide. In general I like all B vitamins. The cancer part is very scary to me, I’ll have to research it further. I would never take a supplement that has even 0.001% chance of causing cancer. I have officially declared war on cancer, diabetes and cardiovascular diseases. If people could avoid these three most if not all people could easily live to over 90.

[Steve_Combi]

I’ve posted on this before in detail, just not sure where it is now so forgive the repetition.

For GHRH we use a combination of CJC1295-noDAC (250mcg) + Ipamorelin (400mcg), 2 peptides that stimulate the “natural” production of HGH. Peptides work best as an injection, subcutaneous. This combo is used 5 nights a week, 3 weeks a month since August 2023.

Tirzepatide is our current glucose control peptide, dose for that would be somewhat iterative, depending on your objectives. Since we are not diabetic, our dose is lower than what a diabetic would require. We started this for weight loss and take 3mg per week. Will probably switch to retatrutide soon. Had a RT sample and we should be able to lower our dose of that one, as it was more effective than TZ

DHEA has a suggested dose range of 50 to 150mg so we picked a middle range dose.

This is not an inexpensive protocol (at retail pricing) but I’m happy with the results so far.

The original TRIIM trial was more of a proof of concept. TRIIM-X is a more focused protocol where they are working on sorting out accurate dosing, which may prove to be a very individual type of thing. I believe they are monitoring more parameters to nail down the doses.

We have not done any testing other than annual blood work and the Trudiagnostic testing. Both of which have improved significantly this past set of tests. Here are the bosses (my 67y/o wife) Extrinsic results over 4 tests in 3 years. I’ve posed the complete test data in the intro thread I did with all my information.

The big bump up in 2023 was due to covid, we both got it and did a test shortly after to see how it affected our “age” as covid is a potent aging infection. As you can see our “work” after infection led to significant improvements

Here is a good write up on LinkedIn

Intervene Immune Launches Thymus Regeneration TRIIM-X Clinical Trial

[Steve_Combi]

Interestingly they patented this protocol. Fortunately it’s pretty easy to get around it.

US20200254066A1 - Pharmaceuticals and dosing means for human aging reversal ...

[LukeMV]

Someone on facebook wrote a very detailed summary of this video, that I will share here:

Greg Fahy’s presentation at the Rejuvenation Startup Summit 2024

Thymus deterioration and immune system decline:

• The thymus deteriorates rapidly after puberty, with almost no functional mass left by age 30-40.

• This leads to a collapse of the immune system repertoire, with a 98% loss in ability to recognize foreign antigens between ages 60-80.

• Poor immune function is linked to an 80% risk of death within 2 years.

• A recent study showed that removing the remaining thymus tissue increases all-cause mortality risk by 2.9-fold and cancer mortality risk by 2-fold within 5 years.

Impact of immune-related causes of death:

• The risk of death from immune-related causes (including infectious diseases and cancer) increases dramatically with age.

• For people over 50, approximately half or more die from consequences of immune system failure.

Intervene Immune’s approach:

• They use a combination of three known agents: growth hormone, metformin, and DHEA.

• This approach allows for quicker regulatory approval and ensures safety.

• All three agents have individual anti-aging benefits.

Results from the original TRIIM trial (2019):

• MRI evidence of thymus regeneration

• Recovery of naive T-cell production (CD4 and CD8)

• Decline in senescent CD8 cell populations

• Reversal of epigenetic markers of aging (average 2.5 years younger)

• Both extrinsic (immune cell population) and intrinsic aging reversed

TRIIM-XA trial:

• Extension of the original TRIIM trial

• 26 participants (including 6 women) vs. 9 in the original

• Included treatment and growth hormone controls

• Enrolled older and slightly sicker participants

• Added more metrics of functional recovery

Epigenetic aging results in TRIIM-XA:

• Reproduced reversal of epigenetic aging using multiple clocks

• All measured clocks showed regression, including two new ones (skin and blood age clock, and PhenoAge clock)

• Correlation between younger epigenetic age and better health outcomes 2-4 years later

Functional improvements in TRIIM-XA:

• Increased leg strength without exercise

• Improved VO2 max (predicted 15% reduction in mortality rate)

• Enhanced lactate threshold

• Better performance in sit-to-stand test (relevant for avoiding institutionalization)

• Improved lung capacity

• Decreased resting pulse and diastolic blood pressure

• Reduced body fat (14% decrease) and visceral adipose tissue

• Increased lean body mass (1.3 kg gain)

Future directions:

• Developing a novel biological agent

• Creating their own growth hormone production

• Expanding laboratory space for drug discovery

• Exploring re-engineering of the immune system to avoid transplant rejection and autoimmune disorders

NUMERICAL RESULTS

Thymus deterioration:

• By age 30-40, almost no functional thymus mass remains

• 98% loss in ability to recognize foreign antigens between ages 60-80

Mortality risks after thymectomy:

• 80% risk of death within 2 years from poor immune function

• 2.9-fold increase in all-cause mortality risk within 5 years after thymectomy

• 2-fold increase in cancer mortality risk within 5 years after thymectomy

Original TRIIM trial results:

• Epigenetic age reversal: average 2.5 years younger

TRIIM-XA trial demographics:

• 26 participants (vs. 9 in original trial)

• 6 women included

• Average age: 67 (vs. 59 in original trial)

Epigenetic aging results in TRIIM-XA:

• Multiple clocks showed regression, including Horvath’s clock, Hannum’s clock, PhenoAge, and GrimAge

• New clocks (skin and blood age, PhenoAge) also showed regression

Inflammatory markers:

• CRP reduced by approximately 50% within first 30 days of treatment, maintained for the rest of the year

Immune cell improvements:

• Increased total lymphocytes

• Increased percentage of lymphocytes

• Increased recent thymic emigrants

• Increased naive CD4 and CD8 T cells

Functional improvements:

• Leg strength improved significantly without exercise

• VO2 max increased with high statistical significance

• Lactate threshold improved

• Sit-to-stand test performance enhanced

• Lung capacity improved in those with initially high CO2 levels

Body composition changes:

• 14% decrease in body fat percentage

• Reduction in visceral adipose tissue

• 1.3 kg gain in lean body mass

Cardiovascular improvements:

• Decreased resting pulse

• Reduced diastolic blood pressure

Individual case study (Greg Fahy):

• Plasma PhenoAge reduced from 57 to 47 after first TRIIM trial

• Further reduction to 44 after TRIIM-XA trial

• Total reduction of about 10 years over 6.3 year period

Novel therapeutic agent results (preliminary):

• 6-year reduction in plasma PhenoAge in 90 days

• Additional 2-year reduction when combined with TRIIM treatment for one week

[Ericross2]

This is amazing, @LukeMV — thank you.

[DrT]

Thank you for posting the very sobering facts about thymic involution and also for the results obtained from Greg Fahy’s trial. Much appreciated.

I’m in the process of playing “catch up” on background reading about this topic so I wonder if I could ask a question.
I note that GF uses rhGH + DHEA + metformin + Vit D + zinc to achieve results. I also noticed that GF advised that instead of directly assaying for GH levels (expensive) they assay for IGF-1 (cheaper and easier). So blood IGF-1 levels are used as a surrogate for GH levels. Now the question:
“Would an “IGF-1 releaser” achieve the same results as a GH releaser? I believe there are small molecules that cause both GH and IGF-1 to be released.”
My second question is this: “Could such a compound be the “novel agent” alluded to by GF?”

Any comments welcomed.

[LukeMV]

I think it’s a really good question regarding whether the GH secretagogues (or IGF1 releasers as you called them) share the same benefit. I don’t think we know for sure. I’d prefer to stick with the real thing until we know better, however, the secretagogues are much more accessible legally whereas you pretty much have to go underground (black market) for real HGH.

[AgentSmith]

Maybe a clue?: MK-677 seems to compare pretty well to HGH for children with moderate idiopathic growth hormone deficiency.

LUM-201=MK-677=Ibutamoren mesylate

https://investors.lumos-pharma.com/news-releases/news-release-details/encouraging-data-lumos-pharma-oragrowth-trials-presented-annual

Oral LUM-201 1.6 mg/kg/day cohort grew 8.6 cm/year, in line with the expected historical rate of ~ 8.3 - 8.6 cm/year from prior data of moderate iPGHD rhGH treated patients

[RapAdmin]

Dr Greg Fahy who does the TRIIMX trials has tested a new substance that he is being very secretive about. Says it reversed his epi age 6 years in 90 days.

And he’s planning clinical services to be launched soon…

Fast forward video to 11:40

Nina Ruge on LinkedIn: #longevity #healthrevolution #gregfahy #triim #biotech #triimxa | 38 comments?

[DrT]

OK, I’ll take a stab in the dark:
Gallic acid?

[Karl92651]

Has anyone looked into the cost to participate in his Trim-X study? It looks like they are still accepting participants.

[Paul_2.0]

It’s 15k. Quite a lot of money and out of reach for most people.

[jnorm]

@argonaut

Here he is now, 74 years old but looking 30:

lol… I’m 30 and if he looks 30 then I must look like I’m 12. Perhaps I should become a longevity influencer.

[AnUser]

Yes he doesn’t look 30 there, more like 55 or older.