AnUser
#1
Learning about drug metabolism, P450 system is used to detoxify toxic substances in the liver, so I wondered if grapefruit are harmful on its own, and there is an association, but it could be because it affects drug metabolism, or other residual confounding.
When compared with non-consumers, frequent consumers of red wine, tea, peppers, blueberries and strawberries were at reduced risk of all-cause mortality (P<0·05), with the strongest associations observed for red wine and tea; multivariable-adjusted hazard ratios 0·60 (95 % CI 0·49, 0·74) and 0·73 (95 % CI 0·65, 0·83), respectively. Conversely, frequent grapefruit consumers were at increased risk of all-cause mortality, compared with their non-grapefruit consuming counterparts (P<0·05).
Considering threads like this:
and that Brian Kennedy has wondered that it could increase side effects with rapamycin use, compared with equivalent dose without it, might be important to consider or research further.
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Karel1
#2
Q1. Could increased all-cause mortality have been caused by severe interaction between GFJ and many other drugs - and thus overdose because users were unaware of this interaction and did not inform their pharmacy of prescribing doctor about GFJ. and/or
Q2. Could GFJ maybe preferently be used by persons having health risks.
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