#1

Hi Folks, Ran across this info mercial youtube: https://www.youtube.com/watch?v=dC8052WTtLk

Leading to this product site: https://nadplusathome.com/product/nad-at-home/

They sell the NAD+ ( Nicotinamide Adenine Dinucleotide) injectable, needles for $350. Seems ripe for FDA cease and desist but thats another issue. Anyone have experience with this product? My wife has a few bad joints that this product may be of help. We are already keto, wear CGMs, fast, red light, PEMF. This might be a help.

I’ve been on rapa and the Johnson’esk kitchen sink for a few years, and doing ok.

Tnx to all here! Curt

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#2

It appears that NAD+ via IV is rapidly converted. I’m not convinced that IV application of NAD+ provides any better result than using a precursor like NR or NMN. I’m personally not interested in doing IV therapy that would be required for a lifetime to get a benefit.

I don’t see any studies on subcutaneous injection and I’m pretty sure? NAD+ orally has zero benefit due to the action of the digestive system.

A lifetime of taking an oral supplement is something I can tolerate.

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

In conclusion, this study was able to reveal for the first time some very useful, previously unknown, information about the fate of exogenous IV NAD+ in humans including, the overall safety and tolerability of an IV NAD+ infusion at a rate of 3 μmoles/min, the rapid sequestering of NAD+ from the plasma, the likely contribution of both NAD+ glycohydrolase and NAD+ pyrophosphate activity in the metabolism of NAD+ and the apparent efficient renal tubular reabsorption of NAM.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751327/b

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#3

Spend the $350 on more Rapamycin.

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#4

The evidence on NAD alone is sketchy, and this new concoction even less. Don’t waste your money.

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#5

I’ve been taking NMN for NAD boosting. It helps with jet lag (I don’t get jetlagged when I take NMN) and an energy boost (placebo?). Due to its effects on jet lag, I know it is doing something. Whether it is going to improve my lifespan is another question. There are many other things that I feel are more useful. NMN is just useful enough that I haven’t dropped it yet.

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#6

@DeStrider Did you ever try niacin or nicotinamide (or NR) to see if you get the same effect? I have on occasion felt an energy boost after taking 500mg of niacin before a workout. I think the key was feeling low energy at first (for unknown reasons). I’ve never felt anything from nicotinamide (or NR, when I used to take it); maybe it’s a dosage thing.

I also take extra creatine on sleep deprived days for alertness. It does seem to greatly delay the onset of sleepiness without ruining the next sleep.

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#7

No, I’ve never taken NR or niacin, but I believe they would work as well. Creatine has been wonderful for energy.

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