That’s a bummer about the Ivabradine. Even AI apps said it could work.

Verapamil could be worth a try. I need to scour the internet to see if there are any anecdotes about this.

I think per what Dr Fraser said earlier in the thread, diltiazem is likely the better choice over verapamil.

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Don’t use AI for medical decisions. For now LLMs are quite bad. (They’re good for diagnosis though, but that’s easier than treating…)

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I wonder what AI would have said about Mediator (benfluorex) before it was withdrawn😜! AI only repeats what information is out there, and poor with synthesizing new insights.

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It’s getting better though. o3 results in ARC AGI and Frontier Maths are very exciting. I can’t wait to try it! (hopefully next month?)

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Update on this: small life extension in C. Elegans => Calcium channel blockers reduce aging rate (ARDD video) - #2 by adssx

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Well yes I wasn’t suggesting using AI to make medical decisions, but I think we all can agree they’ve proven to be very useful in this field.

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That’s where I disagree: for now they’re mostly useless and dangerous. Unfortunately. I pay for ChatGPT pro and Perplexity Pro and spend a lot of time testing them on medical questions: it’s bad. The average regular user here is smarter.

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Do they provide references at the end of their answers? Dr. Oracle does, and they’ve always checked out (in agreement with the answer), at least so far for the questions I’ve asked (which admittedly are fairly straightforward questions).

There are some medical AI-specific sites that I would trust over my primary provider.

I have had several primary providers over the years, and I can’t say any of them were current on the latest studies or treatments. I would undoubtedly use AI as a second opinion. The insurance system constrains my primary providers, and AI doesn’t.

Two, I would suggest that you look at: One is a very reasonably paid subscription, and the other is free. They are both better than paid ChatGPT Pro (Which I pay for but do not use for medical advice)

Both of these sites provide references for everything they claim. They never give phony references. You can read the response and references and make your own decision.

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Liner AI also provides references in their responses, although I have seen them answer things a certain way and the accompanying links don’t completely back up what the AI says, so I have to verify the sources they include to make sure.

Which one of these is the free one?

I think AI is a good starting point. ChatGPT will give you references if you ask, so you can verify the response or continue your research.

I’ve had the exact opposite experience using AI, albeit one I’ve modified for my own medical purposes (prompts, etc.) but I challenge my PCP periodically using it and even she’s not infallible :stuck_out_tongue_winking_eye:

I’ve taken many actionable steps using AI. I still think the average human would still choose to see an actual doctor versus AI and that’s proven by the sheer number of unnecessary ER visits in the U.S.

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Open Evidence…

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They provide references. I also have access to Vera Health, a paid AI solution for doctors only. (I’m not a doctor, but I know the team. If you’re a doctor and want access, you can join the waitlist here)

Yes, for simple questions, they’re good. And they’re better than most doctors. Because most doctors don’t even know or follow the guidelines… And yes, for a second opinion or to challenge your PCP they’re also very good, I agree with you @desertshores and @MichGuy12.

But when you go into something more complex, out of the ordinary, or more prospective, without a clear and definite answer, they can say random things, sometimes totally wrong.

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Unfortunately for Open Evidence, after a few questions you’re blocked and told “Unlimited question-asking on OpenEvidence is free for verified health care professionals (HCPs) and medical students. If you are an HCP or a medical student please verify your registration for continued access to free unlimited questions on OpenEvidence.” There’s no way to pay to bypass the gatekeeping. I asked a few “open” questions such as “For someone with hypertension and at risk of cognitive decline (family history + genes), are some antihypertensive drugs better than other? What should they use?” and it’s doing OK! You need to guide it a bit but it eventually suggests telmisartan + amlodipine to reach BP <130/80 mmHg.

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Very interesting Eric Topol’s interview of Lotte Bjerre Knudsen: The Scientist Who Drove GLP-1 Drugs For Obesity and Alzheimer’s

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Davin8r, what are your thoughts on the various laser treatments for face, neck and possibly arms related the possibility of a permanent change in skin pigmentation (or shading) of the areas treated? Are some types of treatments such as Fraxel laser more or less likely than other types of laser treatments to cause any permanent skin pigmentation changes?

I have found https://www.perplexity.ai/ to be pretty good.

I may even pay for the Pro version.

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