Thanks. I just used the code.
ng0rge
#47
Hey, that’s heavy…
Guess I’m right up there with David Sinclair’s list of failures…things could be worse.
1 Like
Ulf
#48
About how many grams per week do you eat of those fish?
Neo
#49
Thanks I used these several times in the past and just did one so this was a great time to restock for my next text in ~3months.
People - when doing experiments here - remember that it takes ~3ish months (similar to HbA1c to “completely update”)
Digby9
#50
Is anyone else here not able to tolerate Omega 3s? I have tried multiple times with excellent sources and each time, around the 72 hour mark I hit the couch. Completely enervated. I stop the supplement and I’m back to normal within 24 hours. I have searched for any info on this and all I come up with is Brian Peskin’s work which is hard to believe as he is the only one with a negative outlook on Omega 3s but he is pushing parent essential oils (PEOs) and he sells them.
Would love some direction on this as I feel that I am missing out on an important health hack.
Neo
#51
There is some risks of AFIB. Have you ever had any issues with that? Apple Watch and other wearables can now check for that - at I believe FDA cleared reliability levels.
Digby9
#52
No AFIB and oddly straight DHA causes the fatigue as well, though it takes longer to hit.
1 Like
I have a 13.2% Omega Index.
I take 1200mg EPA + 1200mg DHA from Momentous omega 3 (1:1 EPA:DHA) because they are certified NSF for sport to be sure they are not contaminated.
Momentous Omega-3 stands out for its exceptional purity, potency, and sustainability. It undergoes molecular distillation for maximum purity, is regularly tested for lead and mercury levels, and contains a minimum of 90% triglyceride-bound omega-3s. Additionally, we’ve enhanced the formula with lipase to improve bioavailability, ensuring you receive the full benefits of omega-3 fatty acids
2 Likes
Here’s some good news re: omega 3’s that I wouldn’t have expected given all the recent negative news on omega 3’s. I take Thorne fish oil.
Assessing the Efficacy of Omega-3 Fatty Acids + Statins vs. Statins Only on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of 40,991 Patients
https://www.sciencedirect.com/science/article/abs/pii/S014628062300662X
3 Likes
William Harris is the founder of Omegaquant. I sent you my results of 9.5 on the index scale. I eat 170grams everyday of sockeye salmon. At least 6 out of 7. I only eat fish once a day.
eat salmon, herring or sardines everyday. I don’t take any fish oil supplements and my index is over 9.5
1 Like
Digby9
#57
Thanks, I think I’ll start that!
ng0rge
#58
Ah, that explains it. Thanks.
@约瑟夫_拉维尔
Great reference. As a stand alone, the evidence for Omega 3’s for vascular disease has been a bit of a fail. It makes sense that DHA/EPA should improve vascular health. Most of my patients are on low dose statins, so this further supports yet another benefit of Omega 3’s.
2 Likes
Fish oil greatly reduces the risk of developing psychosis or schizophrenia.
From Consumerlab.
2 Likes
Open Access Paper:
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per day) and/or omega-3 (1 g per day) and/or a home exercise program on four next-generation DNA methylation (DNAm) measures of biological aging (PhenoAge, GrimAge, GrimAge2 and DunedinPACE) over 3 years. Omega-3 alone slowed the DNAm clocks PhenoAge, GrimAge2 and DunedinPACE, and all three treatments had additive benefits on PhenoAge. Overall, from baseline to year 3, standardized effects ranged from 0.16 to 0.32 units (2.9–3.8 months). In summary, our trial indicates a small protective effect of omega-3 treatment on slowing biological aging over 3 years across several clocks, with an additive protective effect of omega-3, vitamin D and exercise based on PhenoAge.
https://www.nature.com/articles/s43587-024-00793-y
5 Likes
LaraPo
#63
Is the source of Omega 3 important? I take Vegan ultra Omega 3, algae sourced, by Spectrum.
zebit0
#64
AI attempt at summarizing the video and some related sources:
Higher levels of omega-3 fatty acids, particularly EPA and DHA found in marine sources, are consistently associated with increased life expectancy and reduced mortality risk. Observational studies involving over 160,000 participants show those with the highest blood levels of omega-3s have a 17–21% lower risk of all-cause mortality and up to a 5-year increase in life expectancy compared to those with the lowest levels[3][4][23][25]. This benefit is comparable to quitting smoking, which reduces life expectancy by ~4.7 years[3][28].
Key Findings:
-
Cardiovascular and cancer mortality: High omega-3 levels correlate with 21% lower cardiovascular mortality and 19% lower cancer-related mortality[4][20].
-
Omega-3 Index: An index ≥8% (common in populations like Japan) is linked to a 5-year survival advantage over those with ≤4% (typical in the U.S.)[2][4][23].
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Synergy with lifestyle: Non-smokers with high omega-3 levels have the longest survival, while smokers with low omega-3 levels fare worst[5][24].
Mechanisms and Recommendations:
-
Anti-inflammatory effects: Omega-3s reduce chronic inflammation and support specialized pro-resolving mediators (SPMs), which resolve inflammation[1][25].
-
Dietary intake: Consuming 1,000 mg/day of EPA+DHA from fatty fish (e.g., salmon, sardines) or supplements is advised to achieve optimal blood levels[4][17].
Limitations and Considerations:
- While observational data show strong correlations, causation isn’t proven. Randomized trials are needed[4][13].
- Supplements are effective but dietary sources provide additional nutrients[8][18].
In summary, optimizing omega-3 intake through diet or supplementation may significantly enhance longevity, particularly when combined with healthy lifestyle choices.
Sources
[1] Omega-3 may reduce risk of premature death - YouTube https://www.youtube.com/watch?v=r4TppE0LDxs
[2] The Impact Of Low Omega-3s On Your Health - Dr Rhonda Patrick https://www.youtube.com/watch?v=zbQspHyW1l8
[3] Higher levels of omega-3 acids in the blood increases life … Higher levels of omega-3 acids in the blood increases life expectancy by almost five years | ScienceDaily
[4] Higher Omega-3 Levels Associated with Improved Life Expectancy Higher Omega-3 Levels Associated with Improved Life Expectancy | Saint Luke's Health System
[5] Can omega-3 fatty acids increase life expectancy? Can omega-3 fatty acids increase life expectancy?
[6] How to increase your life expectancy by 5 years using omega-3s https://www.youtube.com/watch?v=rWXZQtvgl3c
[7] How Vitamin D, Omega-3s, & Exercise May Increase Longevity https://www.youtube.com/watch?v=bhkxidN2M9Q
[8] Omega-3 Fatty Acid Supplements. Why you should take them https://www.youtube.com/watch?v=UVx2deSGGPY
[9] Having higher levels of omega-3 acids in the blood increases life … Having higher levels of omega-3 acids in the blood increases life expectancy by almost five years - News - Hospital del Mar Research Institute
[10] Dr. Bill Harris on the Omega-3 Index - YouTube https://www.youtube.com/watch?v=-f-CFQxaUY4
[11] Life-Expectancy Impact of Fish Oil - Life Extension Life-Expectancy Impact of Fish Oil - Life Extension
[12] The Powerful Longevity Benefits of Omega-3 | Dr. Rhonda Patrick The Powerful Longevity Benefits of Omega-3 | Dr. Rhonda Patrick
[13] Fish oil supplements, longevity and aging - PMC Fish oil supplements, longevity and aging - PMC
[14] Are Fish or Fish Oil Supplements Good for the Heart? Are Fish or Fish Oil Supplements Good for the Heart?
[15] Fish oil supplements, longevity and aging - PubMed Fish oil supplements, longevity and aging - PubMed
[16] Longevity Benefits? Omega-3 & Fatty Acid Longevity … - YouTube https://www.youtube.com/watch?v=0DPgZlvpqC4
[17] Can Healthy Omega-3 Levels Help You Live Longer? - Medichecks Can Healthy Omega-3 Levels Help You Live Longer?
[18] Getting Enough Omega-3s in Your Diet May Help You Live Longer Getting Enough Omega-3s in Your Diet May Help You Live Longer
[19] Intakes of omega-3 fatty acids and risks of all-cause and … - PubMed Intakes of omega-3 fatty acids and risks of all-cause and cause-specific mortality in people with diabetes: a cohort study based on NHANES 1999-2014 - PubMed
[20] Effect of omega-3 fatty acids on cardiovascular outcomes - The Lancet https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00277-7/fulltext
[21] People with a higher Omega-3 Index lived longer than others, study … People with a higher Omega-3 Index lived longer than others, study shows
[22] A Long‐Term Follow‐Up of the Alpha Omega Cohort - AHA Journals https://www.ahajournals.org/doi/10.1161/JAHA.121.022617
[23] Study: Low Omega-3 Index is just as powerful in predicting early … Study: Low Omega-3 Index is just as powerful in predicting early death as smoking
[24] Incredible Impact Of Omega 3 For Longevity - YouTube https://www.youtube.com/watch?v=x3O3QvQtYII
[25] The Powerful Longevity Benefits of Omega-3 | Dr. Rhonda Patrick https://www.youtube.com/watch?v=78KWea7vx7M
[26] Dr. Rhonda Patrick - This is The Only Supplement that ACTUALLY … https://www.youtube.com/watch?v=Sxxy6bUlX28
[27] Can omega-3 fatty acids increase life expectancy? Can omega-3 fatty acids increase life expectancy?
[28] Higher levels of omega-3 acids in the blood increases life … Higher levels of omega-3 acids in the blood increases life expectancy by almost five years | ScienceDaily
[29] Association between dietary omega-3 fatty acid intake and all-cause … https://www.nature.com/articles/s41598-024-78486-0
[30] Higher ratio of plasma omega-6/omega-3 fatty acids is associated … https://elifesciences.org/articles/90132
[31] Higher ratio of plasma omega-6/omega-3 fatty acids is associated … https://pmc.ncbi.nlm.nih.gov/articles/PMC9882493/
[32] Blood n-3 fatty acid levels and total and cause-specific mortality from … https://www.nature.com/articles/s41467-021-22370-2
5 Likes
adssx
#65
Rhonda Patrick is a bullshitter. DHA supplementation is detrimental to your health: Predicting Alzheimers & Dementia (and minimizing risk) - #608 by adssx
EPA supplementation might have some cardiovascular benefits, though.
5 Likes
