Agetron
#180
ANNOUNCED A year ago - wonder when we will see updates - human clinical trial for rapamycin’s effect on teeth and mouth is going to happen. Matt Kaeberlein’s Assistant Jonathon An, Ph.D. at UW.
Link: UW periodontal study receives FDA approval for anti-aging drug use - UW School of Dentistry.
The FDA will look at the effects of rapamycin on participants’ periodontal disease, but as the first FDA-approved study to use rapamycin, other research groups will have a keen interest in a variety of its outcomes.
Jonathon An was the one to compare rat peridontal disease in aging to be like humans in aging. The rats had a reversal of peridontal disease and teeth bone regrew!
A very measureable end-point for human, non-organ replacement, use of rapamycin.
Also earlier this month I saw my dentist for a cleaning - she noted that 4 areas of #4 peridontal disease was noted a year ago in x-rays. All repaired and healthy at this visit. Mouth all #3 normal - healthy. I attribute the reversal to a combination of rapamycin and taurine use the past year.
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Pupcuts
#181
@RapAdmin - Oh my gosh! So excited! i just made my first batch of toothpaste. I took your suggestion and used 100 pills instead of 10. I used 2 teaspoons (10 ML) of transcutol. Was afraid it might be a little too runny but ended up being glad i did as, like you said, it was a bit of a challenge mixing it into the toothpaste. I got a stronger handheld mixer from Amazon like you suggested and it made it through but even on high it slowed down a bit powering through the thick parts.
What was interesting to me was that the outer film on the rapacan (Eris) that I used was really tough. You cant see it when you look at the pill but believe me it’s there. I too had pieces of the outer shell left. It ended up straining it thru a tea strainer. The powder fell thru and the weird looking outer part stayed in the strainer. It looked sort of like rice paper but was almost impossible to crush. I added a couple pictures to show what i mean.
I also got my teeth cleaned about 3 weeks ago and my hygienist took some measurements of my gum pockets. She is very interested to see if this works. She gave me a curved plastic hypo and i am going to try squirting some of the rapa in between my teeth on the really recessed ones. Once i floss and rinse all of it will come out i am sure but maybe it will help. Also using 100 pills and 2 teaspoons of transcutol makes too much toothpaste to all fit back in the jar so Im glad i got that from her.
Thank you again for taking the time to post this!
Fingers crossed my dental numbers are better in 6 months or a year!
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I have made a lot of progress on my gums. Oddly enough the first thing that really reduced inflammation was sucking melatonin at night.
I think the mechanistic theory is that the gums are fighting hard against all sorts of infections. This, therefore, causes more ROS than you get in other cells ordinarily and that damages the mitochondria. Hence if you can protect against the ROS (melatonin) and improve the mitochondria (Rapamycin and potentially other things) then you can stop further recession and actually reduce pockets. It remains useful to do proper dental hygiene, but systemic and topical Rapamycin clearly has potential.
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Pupcuts
#183
Interesting about the melatonin. What is ROS?
I recently began putting a dental probiotic in my cheek and just letting it melt there overnight at someone’s suggestion. Very interested in all these hacks for your teeth and gums. And am also happy to find my dental hygienist is encouraging this and interested in the results. Cant wait for July to see if there are any changes yet!
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Jay
#185
Sol, I like your idea. It appears to be less messy than the method I’ve been using. Tell me how much (of each) of Rapamycin, water, and transcutol you use in your rapa serum and how many drops you put on your toothpaste. That will save me the time required to think through the problem. Yes! I’m the typical male … lazy!
sol
#186
I think I’ve posted this serum formula before, but can’t find it. Here you go:
Crush five 1mg rapa pills into very fine powder. (I started with spoon and bowl, and now I use motar and pestle.) Add 1 tsp transcutol. (Careful with transcutol because it can ruin all kind of finishes. I measure over the sink and rinse well.) I use glass (with glass dropper) for serum rather than risk transcutol and rapa in plastic. (Yes, transcutol ships in plastic, but I’m ignoring that for now. Maybe I should transfer it to glass when I get it shipped to me?) Let rapa and transcutol sit for a bit to dissolve. (I have found contrary opinions about whether this step matters, and my serum still has grit.) Add 2 tsp distilled water. Shake before each use.
I like my formulas as simple as possible, so I’m always looking for the minimalist approach. LMK if you improve on this in any way.
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Pupcuts
#187
Nice! Can i ask what kind of serum you use? This is for your face. right? And what is the amount of serum? Im trying to figure out the percentage of rapa solution to mix with a nice skin cream. Thanks for posting!
sol
#188
If I understand your question correctly, @Pupcuts , serum is the resulting liquid from the recipe I provided above. If I were basing my formula on cream rather than water, I’d replace the water with cream.
Definition #2, Serum Definition & Meaning - Merriam-Webster
a usually lightweight cosmetic preparation especially for use on the face
specifically : a typically water-based, often concentrated preparation that lacks lubricating and thickening agents
Pupcuts
#189
Whoops, my bad. Let me rephrase my question please. Im trying to figure out what percentage of a rapa solution to use in the stuff I want to put on my skin.
So you use 5 one mg, pills crushed up and mixed with 1 tsp. transcutol and then you only add 2 tsp. of distilled water. So in your whole batch is 3 tsp. of liquid. Using the @RapAdmin recipe, one teaspoon is 5 grams, so 3 teaspoons would be 15 grams. 5 divided by 15 would come out to .33%?
I know with the toothpaste anywhere between 0.1% up to 2% is used. I am wondering if you know or have read what a good solution percentage might be for anything you put on your skin. Thanks!
sol
#190
I aim for no more than 30% transcutol. I use the serum as I described. On my skin. A drop or two on my toothpaste before brushing. Hope this helps.
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I just got my transcutol and this is on my to do list!
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A word of caution…I mixed my rapa toothpaste up and began using it. I was a bit overzealous, lol I not only brushed my teeth but also my gums, tongue and the roof of my mouth, pretty rigorously. I ended up making the recession WORSE on one tooth! Egad! I was always a rigorous brusher, which got me into this situation in the first place. I should have known better. So now i am all about easy does it. Good luck on your endeavor!
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Pupcuts
#193
What is the final final consensus regarding rapa being absorbed into the mucous membranes? Specifically the mouth. Some folks over on another chatroom say it definitely does get absorbed but i would love to hear opinions from folks here on that. I purchased some dental whitening trays and though i might try putting some rapa in the trays and sleeping with it. I grind my teeth in my sleep anyway and have used similar trays for that with no problem. Just wonder if it might be too much. Thanks!
Pupcuts
#194
Love your post! Can i ask if you brushed with rapa or took it orally? I bought some dental teeth whitening trays and thought i might put some of my rapa toothpaste in them and wear them when i sleep but i unsure if rapa is absorbed thru the gums or not. Didnt want to overdo it an dont know where to look for information about rapa absorption into mucous membranes…
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I think it would, just like skin for the rapamycin skin cream, especially if you are using transcutol or other solvent / reagent. I’ve never seen any reports of people trying it in the dental whitening trays before - and of course, no research on something like this is available. Perhaps try it and see how it goes?
Pupcuts
#196
Thanks so much for the reply! But here’s the rub…according to Dr. Mok (has videos on rapa on Youtube) they have done studies, i believe in the Drexel study, that showed that the rapa DID NOT absorb thru the skin of the participants in the study. That is why it is considered so safe for use with the teenagers that are using it for facial problems. Sorry I cant remember the name of what they have on their face but it is more than just acne. I read about it somewhere but cant find it again. In my other chat group it is believed that rapa does not absorb thru the skin BUT, no one knows, at least that i can find, if it absorbs thru the gums, which are not the same as skin.
Of all my groups this is the my go-to group as folks here seem pretty informed about rapa but man this one is a mystery…
Yes - it did not go through the skin into the blood stream, but it did get “into” the skin and thus the benefit (it it didn’t go into the skin how can it do anything). See here: Rapamycin May Slow Skin Aging (Drexel U. Study)
But most of us here are not trying to avoid rapamycin the bloodstream, we take it orally and topically.
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Pupcuts
#198
Ahhhh…of course, thank you for that clarification. So I wonder, if i not only brushed with my rapa toothpaste but also slept with the toothpaste in my dental trays at least a few nights a week, if it would be overkill. I feel like a risk taker, I am going to try it. Lol. Thank you again for such a quick reply and always helping! 
I had my dental hygenist measure my gum pockets before i started this so i will share my results when I go back to her.
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Agetron
#199
I only take rapamycin orally 6 mg once a week.
I also think Taurine… one teaspoon in the coffee each morning helped my teeth.
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