DIY Rapamycin Toothpaste and Flossing Paste

[relaxedmeatball]

@Jay

Using Sensodyne toothpaste solves the problem within two weeks.

Just a quick note: make sure the toothpaste contains the ingredient “Novamin”. Sensodyne sells a bunch of different toothpastes, but only the one with that specific ingredient actually works for sensitivity.

And with regards to this whole thread: what is the proposed mechanism of action here? Gums recede with age, and how is inhibiting mTor in the mouth epithelium supposed to help with that? I don’t quite “get” it.

[A_User]

@relaxedmeatball

Just a quick note: make sure the toothpaste contains the ingredient “Novamin”. Sensodyne sells a bunch of different toothpastes, but only the one with that specific ingredient actually works for sensitivity.

I think it’s a bandaid and only work while the ingredient is on the teeth, and unsolicited advice: stannous flouride toothpaste can be considered the best toothpaste in general according to different metrics and studies depending on your priorities:

Bryan Johnson Longevity Protocol Discussion (2024 / 25)

I don’t believe there is anything better than Stannous (latin for tin) flouride. There’s something with the addition of the tin that brings oral health benefits greater than that of sodium flouride, for example, which I don’t believe the special apatite toothpaste in the video have shown. Stannous fluoride is an anti-bacterial agent that’s clinically proven to protect against gingivitis, plaque and tooth sensitivity, while still providing the trusted cavity protection you expect from Crest. Although sodium fluoride protects against cavities, it doesn’t provide protection from these other conditions. Crest Pro-Health Toothpaste is the only brand that offers such a wide range of benefits in just one tube! I can compile the evidence and compare it with the toothpaste in the video (BioMin) side by side, if someone wants. Sodium flouride in regular toothpaste is not anti-bacterial. Hype, by the way:

[relaxedmeatball]

@A_User

I think it’s a bandaid and only work while the ingredient is on the teeth

It is like a bandaid, but the effect is quite long lasting, in my experience. I had horrible sensitive teeth, and a few days after using Novamin 2x per day, they were significantly less sensitive. After using it for several years now, I simply don’t have sensitive teeth any more and haven’t thought about it for a long time.

In terms of cavity prevention, tooth decay, tooth loss, I have absolutely no idea. But being able to have a cold drink without wincing in pain is a huge quality of life upgrade!

[Steve_Combi]

If DIM works as indicated in several studies it is definitely something to add to oral care routines. Plus it’s dirt cheap.

I’m going to add this to my mouth wash.

Also looks good for skin care…

https://journals.asm.org/doi/10.1128/spectrum.02056-21

In the present study, we investigated the antibacterial and antibiofilm activities of 20 indoles against C. acnes. Of the indoles tested, indole-3-carbinol at 0.1 mM significantly inhibited biofilm formation by C. acnes without affecting planktonic cell growth, and the anticancer drug 3,3′-diindolylmethane (DIM) at 0.1 mM (32 μg/mL) also significantly inhibited planktonic cell growth and biofilm formation by C. acnes, whereas the other indoles and indole itself were less effective. Also, DIM at 0.1 mM successfully inhibited multispecies biofilm formation by C. acnes, S. aureus, and C. albicans. Transcriptional analyses showed that DIM inhibited the expressions of several biofilm-related genes in C. acnes, and at 0.05 mM, DIM inhibited hyphal formation and cell aggregation by C. albicans. These results suggest that DIM and other indoles inhibit biofilm formation by C. acnes and have potential use for treating C. acnes associated diseases.