#328

u mean to grind whatever else is in the tablets not grinding rapamycin

#329

I put 60 1mg pills of Rapamune in the grinder and push the button. Nice and easy.

2 Likes
#330

dmso or transcutol or neither eg at 0.2% the published optimal concentration

Ingredients Formula Ideal Amount Actual Amount
Rapamycin 1800.0 mg 1800.0 mg 1801.49 mg
Ethanol 10.0% 90.0 ml 90.0 ml
Propylene glycol 40.0% 360.0 ml 360.0 ml
Benzyl alcohol 1.5% 13.5 ml 13.5 ml
Benzoate buffer pH 4.05 5.0% 45.0 ml 45.0 ml
Total Volume q.s. WFI 900.0 ml 900.0 ml 900.0 ml
Final Concentration 2.0 mg/ml 2.0 mg/ml 2.002 mg/ml

just one of the many published ways with neither though ofcourse rapamycin does NOT mean rapamune tablets ! For those who insist on doing it that aā€¦ way and if you are going to for example spend money on transcutol then you might as well also buy micellar water which is less expensive as the published report comparing different things added to specifically rapamune tablets which included putting them in different cosmetics such as Cerave, Aquaphor etc. and others and one using only micellar water by itself the one using only micellar water by itself (plus the tablets) came out first as to maximum amount absorbed into skin. So if u are going to do it that way best you search for that published article(s) on the internet and others like it to see exactly what came out number one.

#331

Would you please share this study?
I could only find this, but I beleive it is not the one you mention.

#332

One advantage of using a commercial skin cream as your base is that you get whatever benefits that cream offers and they are designed to be stable. At a minimum the skin cream is formulated to prevent infection when people stick their fingers into the jar to apply the cream. With my cream I have the advantage of never having to open the jar. I just push on the side and a little bit of cream comes out of a small hole on the top and then it reseals.

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#333

Would you please post the proof that dangerous microbial contamination will likely occur and what food will the microbes use for proliferation? You are sounding like a Chicken Little sounding the alarm.

Since we have quite a number of users of DIY skin creams, lotions and sprays for many months with no reports of dire consequences, I will continue to make and use my own mixture. I have been using my DIY mixture of Transcutol for more than a year and am very happy with my results. I use crushed 1mg Rapacan tablets, Transcutol, and water, which are filtered and put in small spray bottles.

My batches last about six weeks. As you can see rapamycin is highly soluble in Transuctol.

Transcutol, not: ā€œThese encouraging results confirmed that polymeric micelles enabled development of aqueous SIR formulations capable of targeted epidermal delivery.ā€
Has a proven track record.

Sounds like they are on track to find something patentable.

Transcutol: ā€œThis excipient offers advantages over other enhancers for it is clear (transparent) non-volatile and nearly odorless. Unlike oleic acid, azone, and DMSO, TranscutolĀ® does not compromise the integrity of the skin structures. With superior solubilization power, unique physicochemical properties, and well-established safety profile, it is an ideal penetration/permeation enhancer.ā€

https://www.researchgate.net/publication/345497760_pharmaceutics_Comparison_of_the_In_Vitro_and_Ex_Vivo_Permeation_of_Existing_Topical_Formulations_Used_in_the_Treatment_of_Facial_Angiofibroma_and_Characterization_of_the_Variations_Observed

5 Likes
#334

@scta123 I had no reason to record that article because i have enough sense NOT to use rapamune tablets ever for anything much less pay 100 times the price for rapa. You do your search and find that article if you want to use that. Why on earth would you do anything other than use the pure powder ? If i had to pay that gigantic price for rapa i would never be using it.in the first place. But i tell you that is what the article read - number 1 was using micellar water alone. For one thing that should be obvious is you are sure not going to get a nano nor even micro sizedā€¦ micelleā€¦ nor emulsion by trying to mix crushed rapamune tablets with a viscous face or skin cream. That article u quoted has nothing to do with rapamune tablets which should have been obvious. If it isnā€™t obvious to you the first prescription i quoted also has nothing to do with rapamune tablets. Those are 2 different unrelated issues i posted. The first to show there are many prescriptions that donā€™t use either dmso nor transcutol which had NOTHING to do with rapamune tablets. The 2nd was to do with using rapamune tablets in the case of a comparison experiment or report that was done. Seems u have a lot of study to do. Crushing rapamune tablets using pistil and mortar and the article you mentioned is like comparing something out of the stone age to technology of the 21st or 20th centuries. The stone age did not even know about even ā€¦micro nor micelle etc. Ofcourse that article you mentioned has nothing to do with the one i mentioned concerning rapamune tablets. What is your main reason for using a rapa cream or gel or ointment in the first place ? If its for a specific issue, other than to do with say trying to get repigmentation of hair, like i said u will likely be better off using tacrolimus and/or 4-ethoxybenzaldehyde.In case u didnā€™t know tacrolimus is also used just like rapa for organ transplant rejection.

#335

I have as yet never read anything about anyone who was ever damaged nor even noticed dmso carrying other things into skin or whatever.

1 Like
#336

I wish I could get sirolimus powder, but unfortunately it is not available in Europe to my knowledge. You cannot order medicines from outside EU, they get confiscated by customsā€¦

#337

Donā€™t you even realize how small 1mg of rapamycin is?
You would have to pay for 100 milligrams to have even a workable amount. Compounding pharmacies are NOT supplying pure rapamycin powder. They have to dilute it with excipients to make it practical to work with, make it into pills, or encapsulate it. I am not sure that the compounding pharmacies are receiving pure undiluted rapamycin. If they do they are not selling it to you. If you can prove otherwise I will stand corrected.

4 Likes
#338

that was just my point to the person who seemed to think otherwise. i donā€™t deal with compounding pharmacies. i ordered 5 grams NOT mg at a time from mesochem

#339

so in that case it seems u would also have same problem getting tablets eg rapamune or other from India

#340

I can get prescription rapamune in local pharmacy. That is all what is available to me. I can also order sirolimus ointment/cream in desired concentrations but it is just mix of some sort of basic pharmacy ointment and powdered sirolimus. No penetration enhancement. That is why I would want to make my own. If I travel to somewhere where I can order powdered rapamycin, I might get some.

1 Like
#342

Charles Brenner tells us we should be adding NR to our skin cream. Apparently it increases elasticity or something like that.

1 Like
#343

Crushing rapa tablets which is what the compounding pharmacy did is crushing the other things besides rapa in the tablets mostly as the rapa is
only a very small percent of the total like 1 or 2mg or so depending upon the particular pill/tablet or whatever. Most likely for lack of better words the rapa is ā€™ microscopically coordinated ā€™ with whatever in some way and one is NOT going to undo that to get the pure rapa which is what is used in the superior penetration articles by some heathan method of crushing tablets which is macroscopic. Those articles with the superior penetration are from micellar and/or emulsions and micro encapsulatedā€¦ often in the nanometer size range but not always but at most a few hundred micrometers. So most all the favorable things it says using transcutol and/or whatever or even dmso to get micro encapsulation is NOT going to happen by using/crushing tablets such as rapamune or whatever. Those using transcutol or whatever there are always other things also besides transcutol or dmso etc and any significant favorable penetration is not going to happen by starting off with only crushing tablets in the way that the compounding pharmacy or u or anyone else does.

#344

donā€™t know what exactly is NR but applying a solution of urea to skin prior to applying what ever will likely help more.

#345
#346

I am blessed not to have many wrinkles but I do have frown lines on my forehead and I never had Botox and am thinking about it as I am out in the sun a lot hence the squinting. But I donā€™t want to have to do it over and over again with Botox. Any suggestions or better alternatives?

#347

My sense is that sunscreen rigorously applied is the best thing you can do for your skin.

5 Likes
#348

I donā€™t do Botox for any area. My last one was some 15 years ago. I deal with ā€œelevenā€ (11) wrinkles between my eyebrows by applying meso to that area. It requires only 2 drops, one in each line at a depth of 1 mm (no bleeding). Then, couple hours later, I apply a triangle sticker called ā€œsmoothieā€ to that area for several hours. And the miracle happens - ā€œ11ā€ is gone. If your ā€œ11ā€ is not very pronounced, wearing just one sticker triangle (smoothie) on that area at night may cure it forever.

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